Ipca Laboratories Pvt Ltd.
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CompositionValdiff-M 500 Tablet is primarily used to manage blood sugar levels in adults with type 2 diabetes mellitus. This combination medicine is part of a group of medicines known as oral antidiabetics.
In addition to controlling blood sugar, it also helps reduce the amount of glucose produced by the liver and improves the body's sensitivity to insulin. It is used alongside a balanced diet and regular exercise for optimal results.
Valdiff-M 500 Tablet is used for the following:
Improving blood sugar control in adults with type 2 diabetes mellitus
Reducing hepatic glucose production: This refers to decreasing the amount of glucose or sugar that the liver produces.
Decreasing intestinal glucose absorption
Increasing insulin sensitivity
Follow these instructions while taking Valdiff-M 500 Tablet:
Swallow the tablet whole with a glass of water. Do not crush or chew the tablet.
It's suggested to take this medicine twice daily along with meals.
Always follow your doctor's advice regarding the correct dose. Do not exceed the recommended dose without consulting your doctor.
If you wish to stop taking this medicine, speak to your doctor first. It's essential not to discontinue it on your own.
Valdiff-M 500 Tablet is taken orally.
While taking Valdiff-M 500 Tablet, you may experience the following side effects:
Diarrhoea
Headache
Upper respiratory tract infection
Nasopharyngitis
Nausea
Arthralgia: This is a medical term for joint pain, which can occur in any body part where two or more bones meet.
Most side effects are temporary and generally harmless, which resolve on discontinuing the use of Valdiff-M 500 Tablet. However, if you experience any serious side effects or worsening of any of the symptoms, please consult your doctor. Here are some tips to manage common side effects:
Diarrhoea: Try taking Valdiff-M 500 Tablet with food to lessen this effect.
Nausea: If you feel nauseated after taking this medicine, consider changing the time of consumption to post meals.
Valdiff-M 500 Tablet contains two active ingredients:
Metformin (500 mg): As a biguanide-type medication, metformin works primarily by decreasing glucose production in the liver. It also improves insulin sensitivity which enhances glucose uptake by the body's cells and reduces glucose absorption in the intestines.
Vildagliptin (50 mg): Classified as a dipeptidyl peptidase-4 (DPP-4) inhibitor, vildagliptin works by blocking an enzyme that breaks down incretin hormones such as glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP). By inhibiting DPP-4, vildagliptin prolongs the action of these hormones leading to increased insulin secretion and reduced glucagon levels in a manner dependent on blood glucose levels.
If you are pregnant, caution is advised while taking Valdiff-M 500 Tablet. It is best to consult your doctor before taking this medicine.
Valdiff-M 500 Tablet is not recommended when breastfeeding. You should consult your doctor to understand the potential risks and benefits.
Excessive alcohol intake increases the risk of lactic acidosis while taking this medicine. It's advisable to avoid excessive alcohol consumption when taking Valdiff-M 500 Tablet and to consult your doctor for best advise.
If you have liver problems, it's advisable to avoid using Valdiff-M 500 Tablet due to potential health concerns. Discuss your liver health with your doctor before starting this medication.
Valdiff-M 500 Tablet is contraindicated in severe kidney impairment. For moderate kidney impairment, it is not recommended. Always consult your doctor if you have any kidney problems before starting this medicine.
No specific precautions are necessary while driving or operating machines when taking Valdiff-M 500 Tablet. However, if you experience side effects such as dizziness or fatigue, avoid such activities and consult your doctor right away.
If you are allergic to metformin, vildagliptin, or any other ingredient in this medicine, avoid taking Valdiff-M 500 Tablet. Always inform your doctor about any known allergies before starting this medication.
This medicine is not recommended for children under 18 years of age. Always consult your doctor before giving any medicine to a child.
Elderly patients should take Valdiff-M 500 Tablet under medical supervision as they may be more prone to its side effects and may have pre-existing liver and kidney issues. Your doctor will guide you based on your overall health status.
Valdiff-M 500 Tablet interacts with the following medicines:
Carbonic anhydrase inhibitors: Medicines like topiramate and zonisamide can increase the risk of lactic acidosis when taken with Valdiff-M 500 Tablet. More frequent monitoring may be needed.
Insulin secretagogues: Medications like sulfonylureas can increase the risk of hypoglycaemia when taken with Valdiff-M 500 Tablet. A lower dose of insulin secretagogue may be required.
Valdiff-M 500 Tablet does not have any known specific food interactions. However, maintaining a balanced diet is always beneficial for managing diabetes.
Valdiff-M 500 Tablet interacts with the following diseases:
Severe renal impairment: As this medicine is contraindicated in patients with severe renal impairment (eGFR below 30 mL/min/1.73m2), it should not be used in patients with severe renal impairment.
Liver disease: People with liver disease should avoid using Valdiff-M 500 Tablet as it could worsen their condition.
Metabolic acidosis: Patients with acute or chronic metabolic acidosis, including diabetic ketoacidosis, should not take this medicine as it could exacerbate their condition.
Heart disease: Patients with a history of heart disease should exercise caution while taking Valdiff-M 500 Tablet as it may increase the risk of heart failure.
The daily dose of Valdiff-M 500 Tablet should be taken as instructed by your doctor. This dosage may vary based on the severity of your condition and how response to the medicine. Always stick to the prescribed dosage and never increase it without first consulting your doctor.
If you accidentally take more Valdiff-M 500 Tablet than prescribed, you might experience symptoms that are more intense than the usual side effects. These may include headaches, nausea, and diarrhoea. If you have overdosed, inform your doctor for appropriate advice.
It's important not to miss a dose of Valdiff-M 500 Tablet. However, if you do forget to take a dose, you should take it as soon as you remember, unless it's nearly time for your next one. In that case, skip the missed dose and continue with your regular schedule.
Store Valdiff-M 500 Tablet at room temperature, ideally between 15°C and 30°C.
Keep the medicine protected from moisture and light.
Keep it out of reach of children.
Always ensure to use it before the expiry date mentioned on the package.
Incorporate regular physical activity into your daily routine to enhance insulin sensitivity and help manage blood sugar levels.
Maintain a balanced diet, low in sugary and processed foods, which can assist in better control of type 2 diabetes. Regularly monitor your blood glucose levels as directed by your doctor.
| Drug Category | Biguanide, DPP-4 Inhibitor |
| Therapeutic Category | Antidiabetic |
| Available Dosage Types | Tablet |
| Habit Forming | No |
| Ailment | Type 2 Diabetes Mellitus |
Valdiff-M 500 Tablet is used to manage blood sugar levels in adults with type 2 diabetes, in conjunction with a balanced diet and regular exercise.
This medicine works by two mechanisms: reducing the production of glucose in the liver and improving insulin sensitivity, and increasing insulin secretion while decreasing glucagon levels.
The effects of Valdiff-M 500 Tablet during pregnancy are not well-studied. If you're pregnant, consult your doctor before taking this medicine.
Metformin, an ingredient in this medicine, is present in human milk; it's unknown if vildagliptin is secreted into breast milk. Consult your doctor before use.
Individuals with severe kidney problems, metabolic acidosis, or allergic reactions to metformin or vildagliptin should avoid taking Valdiff-M 500 Tablet.
Common side effects include nasopharyngitis, diarrhoea, headache, upper respiratory tract infection, nausea, and joint pain.
If you experience serious side effects like lactic acidosis or pancreatitis symptoms, stop taking the medicine immediately and contact your doctor.
Check out Editorial Policy
U.S. National Library of Medicine. (2021). Metformin. MedlinePlus. Retrieved 1 April 2024, from https://medlineplus.gov/druginfo/meds/a696005.html
Keating GM. Vildagliptin: a review of its use in type 2 diabetes mellitus. Drugs. 2010 Nov 12;70(16):2089-112. https://pubmed.ncbi.nlm.nih.gov/20964454/
U.S. Food and Drug Administration. (2012). FDA Drug Safety Communication: FDA revises warnings regarding use of the diabetes medicine metformin in certain patients with reduced kidney function. Retrieved 1 April 2024, from https://www.fda.gov/downloads/drugs/drugsafety/ucm280360.pdf
U.S. Food and Drug Administration. (2008). Galvus (vildagliptin) Tablets, for Oral Use. Retrieved 1 April 2024, from https://www.accessdata.fda.gov/drugsatfda_docs/label/2008/021995s007lbl.pdf
We, at Truemeds make a diligent attempt to deliver accurate, expert- drafted and thoroughly reviewed medicine related information to our consumers. However, it should, by no means, be considered a substitute for prescription from a certified doctor or a trustworthy doctor-patient relationship. In fact we detest any form of self medication without expert advice. The sole purpose of the information on our portal is to educate our consumers, which helps improve the communication between a doctor and a patient. The information by no means is complete in its entirety and should not be used to diagnose or treat any medical condition. No amount of information can replace the experience and expertise of a doctor, therefore his/her advice always holds priority and should be followed appropriately.
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