Sazo 500 Mg Tablet 15

Sazo 500 Tablet 15

Wallace Pharmaceuticals Ltd.

Strip of 15 Units

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MRP ~~₹79.29~~

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Composition

Sulfasalazine (500 Mg)

Strength:

500 MG 1000 MG

Sazo 500 mg tablet belongs to a class of medications called anti-inflammatory drugs. Sazo 500 mg tablet is primarily used to treat inflammatory bowel diseases (IBD) such as ulcerative colitis and Crohn's disease. It is also sometimes used to treat rheumatoid arthritis and other autoimmune conditions.

Sazo 500 mg tablet works by reducing inflammation in the body. The medication's active ingredient - sulfasalazine is a combination of two components: sulfapyridine and 5-aminosalicylic acid (5-ASA). Sulfapyridine is an antibiotic that works by reducing the number of harmful bacteria in the intestines. 5-ASA is an anti-inflammatory medication that blocks the production of inflammatory chemicals called prostaglandins.

While Sazo 500 mg tablets are safe and effective, they can cause side effects in some patients. These side effects are usually mild and subside on their own as the body responds to the medication.

Patients with certain medical conditions, such as liver or kidney disease, blood disorders, or allergies to sulfa drugs, should talk to their healthcare provider before taking Sazo 500 mg tablets.

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Inflammatory Bowel Disease: Sazo 500 mg tablet is a commonly used drug for managing inflammatory bowel disease (IBD), ulcerative colitis and Crohn's disease. It helps to reduce inflammation in the colon and improve symptoms such as diarrhoea, abdominal pain, and rectal bleeding.
Rheumatoid Arthritis: Sazo 500 mg tablet is also used to treat rheumatoid arthritis (RA), a chronic autoimmune disease that affects the joints. It helps to reduce inflammation in the joints and improve symptoms such as pain, swelling, and stiffness.
Ankylosing Spondylitis: Sazo 500 mg tablet treats ankylosing spondylitis, a type of arthritis primarily affecting the spine. It helps to reduce inflammation in the spine and other joints and improve symptoms such as pain and stiffness.
Psoriatic Arthritis: Sazo 500 mg tablet is also used to treat psoriatic arthritis, a type of arthritis that occurs in people with psoriasis. It helps to reduce inflammation in the joints and improve symptoms such as pain, swelling, and stiffness.
Juvenile Idiopathic Arthritis: Sazo 500 mg tablet is used to treat juvenile idiopathic arthritis, a type of arthritis that affects children. It helps to reduce inflammation in the joints and improve symptoms such as pain, swelling, and stiffness.

Directions for Use of Sazo 500 Tablet 15

Sazo 500 mg tablets should be taken as your doctor recommends.
Swallow it as a whole with water after your meal to avoid stomach discomfort.
Do not cut, break or chew the medicine.
It would be best to take it at a fixed time for optimal results.
It would be best if you consumed what your doctor prescribes.

Sazo 500 mg tablets are taken orally with food or after meals, as prescribed by a healthcare provider.

The common side effects of Sazo 500 mg tablet include:

Indigestion, heartburn, and nausea: These symptoms can occur due to stomach lining irritation.
Dizziness and headache: These symptoms can occur due to changes in blood pressure.
Changes in taste: Some patients may experience a metallic taste in their mouth while taking Sazo 500 mg tablets.
Ringing in the ears: This side effect is rare but can occur in some patients taking Sazo 500 mg tablets.
Cough: Sazo 500 mg tablet can cause a dry cough in some patients.
Itching of the skin: Some patients may experience itching or a rash while taking sulfasalazine.
Joint pain: Some patients may experience joint pain or muscle aches while taking Sazo 500 mg tablets.
Protein in urine: Sazo 500 mg tablets can cause a protein to appear in the urine, which is usually not a cause for concern but should be monitored by a healthcare provider.
Fever: Sazo 500 mg tablets can cause a fever in some patients, which may indicate an infection or allergic reaction.

Managing the Side Effects:

Most side effects are temporary and generally harmless, which resolve on discontinuing Sazo 500 mg tablets. However, if you experience any serious side effects or worsening of any of the symptoms, please consult your doctor.

Sazo 500 mg tablet treats inflammatory bowel disease, including ulcerative colitis and Crohn's disease. It works by reducing inflammation in the colon through several different ways. One of the ways it works is by blocking the production of prostaglandins, which are compounds that cause inflammation. Sazo 500 mg tablets also block the production of leukotrienes, other compounds that cause inflammation. Additionally, it can help by changing the balance of bacteria in the gut to reduce harmful bacteria and increase helpful ones. By reducing inflammation in the colon through these different ways, Sazo 500 mg tablets can improve symptoms of inflammatory bowel disease.

Pregnancy

There have been cases of children born with neural tube defects to mothers using Sazo 500 mg tablets during pregnancy, while the exact role of Sazo 500 mg tablets in these disorders is unknown. The medication may cause harm to a developing foetus. Pregnant women or women planning to become pregnant should consult their healthcare provider before taking this medication.

Breastfeeding

Sulfasalazine can be secreted into breast milk and may harm a nursing infant. There have been cases of babies of breastfeeding moms experiencing diarrhoea or blood in their faeces while taking the sazo 500 mg tablet. If this occurs, discontinue the sazo 500 mg tablet and consult your doctor immediately. Breastfeeding women should notify their healthcare provider before taking this medication.

Alcohol

Patients should avoid drinking alcohol while taking Sazo 500 mg tablets, as it may increase the risk of liver damage.

Liver

Sazo 500 mg tablets may cause liver damage, particularly in patients with pre-existing liver disease. Patients should consult their doctor if they have a history of liver problems before taking the sazo 500 mg tablet.

Kidney

Sazo 500 mg tablets may cause kidney damage, particularly in patients with pre-existing kidney disease. Patients should notify their doctor if they have a history of kidney problems before taking the sazo 500 mg tablet.

Using Machines & Driving

It is unlikely that sazo 500 mg tablet would impair your ability to drive or operate machines. However, avoiding attentive tasks is recommended if you experience any side effects after taking Sazo 500 mg tablets.

Allergy

Patients who have a known allergy to sulfonamides should not take sulfasalazine. Patients who experience an allergic reaction while taking this medication should stop using it and seek medical attention immediately.

Children

The safety and efficacy of Sazo 500 mg tablets in children have not been established. Therefore Sazo 500 mg tablets are not to be used in children under two years of age. The medication should only be used in children under the guidance of a healthcare provider.

Older Patients

Older patients may be more sensitive to the side effects of Sazo 500 mg tablet, particularly liver and kidney problems. Healthcare providers should monitor older patients carefully while they are taking this medication.

Drug-Drug Interactions

Sazo 500 mg tablet has the potential to interact with several other drugs, including:

Medicines for high blood sugar/diabetes: Sazo 500 mg tablets can affect blood sugar levels and may interact with other drugs used to control high blood sugar or diabetes, such as insulin or metformin. Patients taking these medications should be closely monitored by their healthcare provider.
Digoxin: Sazo 500 mg tablet may increase the digoxin levels in the blood, raising the risk of side effects. Patients taking digoxin should be carefully monitored by their healthcare provider.
Folic acid or folate: Sazo 500 mg tablets may interfere with the absorption of folic acid, which is essential for many processes in the body, including the production of new cells. Patients taking Sazo 500 mg tablets should have their folic acid levels monitored and may require supplementation.
Azathioprine and mercaptopurine: Sazo 500 mg tablets may increase the risk of bone marrow suppression when used with these drugs, which are used to suppress the immune system in organ transplantation and certain chronic inflammatory conditions. Patients taking these medications in combination with Sazo 500 mg tablets should be carefully monitored.
Methotrexate: Sazo 500 mg tablet may increase the risk of methotrexate toxicity when used together. Patients taking these medications in combination should be closely monitored by their healthcare provider.

Drug-Food Interactions

You can usually eat and drink normally while taking Sazo 500 mg tablets. But Sazo 500 mg tablet can interact with

Alcohol: Consumption of alcohol may increase the drowsiness and dizziness caused by Sazo 500 mg tablets. Patients should avoid consuming alcohol while taking Sazo 500 mg tablets.

Drug-Disease Interactions

Here are some drug-disease interactions to be aware of:

G6PD Deficiency: Patients with glucose-6-phosphate dehydrogenase (G6PD) deficiency may experience hemolysis (rupture of red blood cells) when taking Sulfasalazine. Therefore, Sazo 500 mg tablets should be used cautiously in patients with G6PD deficiency.
Blood Disorders: Sazo 500 mg tablets may cause changes in blood cell counts, including a decrease in white blood cells, red blood cells, and platelets. Patients with pre-existing blood disorders should be monitored closely for any changes in blood counts.
Liver Disease: Sazo 500 mg tablet is metabolised by the liver, so patients with liver disease may experience altered drug metabolism and an increased risk of side effects. Dosage adjustments may be necessary for patients with liver disease.
Kidney Disease: Sazo 500 mg tablet is excreted by the kidneys, so patients with kidney disease may experience altered drug excretion and an increased risk of side effects. Sulfasalazine causes crystalluria and kidney stone formation. Therefore, dosage adjustments may be necessary for patients with kidney disease.
Porphyria: Sazo 500 mg tablet can worsen symptoms of porphyria, a rare genetic disorder affecting the production of heme, an essential component of haemoglobin. Patients with a history of porphyria should use caution when using Sazo 500 mg tablets.
Colitis: Sazo 500 mg tablet may worsen colitis symptoms or inflammatory bowel disease. Patients with a history of colitis should be closely monitored while using Sazo 500 mg tablets.
Hypersensitivity or allergic reactions: Sazo 500 mg tablets can cause allergies, including fever, rash, and other skin reactions. Patients with a history of hypersensitivity or allergic reactions to sulfonamides or other medications should use caution when using Sulfasalazine.
Jaundice: patients with jaundice (yellowing of the skin or eyes) should avoid using Sazo 500 mg tablets.

Daily Dose

The recommended dose of Sazo 500 mg tablet is once daily, with food, as directed by your doctor. The dosage may change based on individual factors such as the severity of the condition and response to treatment. It is essential to follow the suggested dosage and not exceed it without consulting your doctor.

Over Dose

If you or someone else takes an excessive Sazo 500 mg tablet by accident, it is essential to take immediate medical attention from your doctor or nearby hospital. Overdose symptoms include brain damage and may cause headache, dizziness and stomach upset.

Missed Dose

If you forgot to take the Sazo 500 mg tablet, take it as soon as you recall or as your health care provider instructed. If the time for the next dosage is close, skipping the missed one is recommended now and resume your regular dosage pattern. Never increase your dosage without consulting your doctor.

Store Sazo 500 mg tablets at room temperature (15-25ºC).
Please protect it from light and moisture.
Keep Sazo 500 mg tablets away from children.
Do not use the Sazo 500 mg tablet after the expiry date has passed

Drink plenty of water to avert dehydration, especially if diarrhoea is a side effect of the drug.
Alcohol can interact with Sazo 500 mg tablets and increase the risk of liver damage.
To ensure proper nutritional intake, include a variety of fruits, vegetables, whole grains, lean proteins, and low-fat dairy products in your diet.
Sulfasalazine may interfere with the absorption of specific vitamins, particularly folic acid. Patients might need to add more folic acid or other vitamins to their diet as a supplement, as their healthcare provider recommends.
Regular exercise can help improve overall health and well-being and help manage some symptoms associated with inflammatory conditions like rheumatoid arthritis.
Sazo 500 mg tablets can raise the risk of infection. Therefore it's crucial to maintain proper hygiene, including washing your hands and avoiding contact with ill people.

Take a Sazo 500 mg Tablet with food to prevent stomach distress.
The Sazo 500 mg Tablet may take 6 to 8 weeks to start working. Continue taking it as directed.
While taking this medication, you must undergo routine blood tests to check your kidney, liver, and blood component levels.
Without consulting your doctor, do not abruptly discontinue taking the drug.
Using Sazo 500 mg Tablet may enhance your skin's sensitivity to sunlight and cause your urine, tears, and contact lenses to turn yellow or orange. Nevertheless, this is harmless and nothing to worry about.

Fact Box

Drug Category	Sulfasalazine
Therapeutic Category	Anti-inflammatory
Available Dosage Types	Tablet
Habit Forming	No
Ailment	Ulcerative colitis, Crohn’s disease, Rheumatoid arthritis

Is the sazo 500 mg tablet a pain killer?

No, Sazo 500 mg Tablet is not a painkiller. It is an anti-inflammatory drug that lessens internal body swelling by minimising inflammation.

Is the sazo 500 mg tablet a steroid?

No, Sazo 500 mg tablets are not steroids. It contains Sulfasalazine as an active component, which is an anti-inflammatory medication.

Is the sazo 500 mg tablet safe?

Sazo 500 mg tablets are safe when used as directed by a doctor. But can cause side effects such as nausea, vomiting, headache, and rash. Serious side effects are rare but may include liver or kidney problems, allergic reactions, or blood disorders. Patients with certain medical conditions should consult their healthcare provider before taking Sazo 500 mg tablets.

How long does it take sazo 500 mg tablet to work?

Sazo 500 mg tablet won't start to work immediately. It could take at least one to three months to notice any improvement in your symptoms.

Is the sazo 500 mg tablet an antibiotic?

Sazo 500 mg tablet is included in the class of medications known as aminosalicylates. Inflammatory bowel diseases like Ulcerative Colitis, Crohn's disease, and rheumatoid arthritis are treated and managed with it.

What is the mode of action of the sazo 500 mg tablet ?

Sazo 500 Tablet acts as an anti-inflammatory agent by preventing the production of prostaglandins, a substance that regulates pain and inflammation. It helps reduce inflammation in the colon, skin, and joints.

Can I take sazo 500 mg tablet at night?

Try to schedule your doses evenly throughout the day and night, with no more than an 8-hour gap between your bedtime and morning dose. When taking sazo 500 mg tablet, drink enough fluids to help avoid any kidney problems.

Is sazo 500 mg tablet safe during pregnancy?

No, using Sazo 500 mg Tablet 15 during pregnancy is not considered safe. There have been reports of children being born with neural tube defects to mothers who used Sazo 500 mg tablets during pregnancy, while the precise function of Sazo 500 mg tablets in these diseases is unknown. The medicine may harm a developing foetus. Pregnant women or a woman who intends to become pregnant should consult their doctor before taking this drug.

Does sazo 500 mg tablet affect the kidney?

Sazo 500 mg tablets can affect kidney function, especially in patients with pre-existing kidney disease. Patients with kidney problems should talk to their healthcare provider before taking Sazo 500 mg tablets.

Can sazo 500 mg tablet damage the liver?

Yes, Sazo 500 mg tablets can potentially cause liver damage in some patients. Patients taking Sazo 500 mg tablets may need to monitor their liver function regularly, especially if they have pre-existing liver disease or a history of liver problems.

Can sazo 500 mg tablet damage lungs?

While it is not a common side effect, Sazo 500 mg can cause lung problems in some patients. Patients who experience any symptoms of lung problems while taking Sazo 500 mg tablets should immediately seek medical attention. Patients with a history of lung disease should talk to their healthcare provider before taking the medication.

Last Updated On 12 Feb. 2024 | 11:03PM (IST)

Certified Content

Written by

Dr. Sachin Singh

Medical Team Lead | 5 years

MBBS

Reviewed by

Dr. Mandeep Chadha

Lead Medical Content Reviewer | 10 years

MBBS, DNB (OBGY)

Check out Editorial Policy

References

KD Tripathi. Drugs for Constipation and Diarrhea. Essentials of medical pharmacology. Eighth Edition. 2019. Page –734-735.
Website, N. (2023, April 21). Sulfasalazine. nhs.uk. https://www.nhs.uk/medicines/sulfasalazine/
Sulfasalazine. Drugs.com. [Revised in June 2022] [Accessed on 13th July 2022] https://www.drugs.com/cons/sulfasalazine.html
Recipharm Uppsala. Health Products Regulatory Authority (HPRA). [Revised in September 2018] [Accessed on 13th July 2022] https://www.hpra.ie/img/uploaded/swedocuments/d3fcb110-b8d2-45fc-bfd2-d9d4dfeeca41.pdf

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