Phexin 500 Mg Capsule 10

Phexin 500mg Capsule 10

Glaxosmithkline Pharmaceuticals Ltd.

Strip of 10 Units

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Composition

Cefalexin (500 Mg)

Strength:

500 MG 250 MG

Phexin 500 mg capsule belongs to the class of antibiotics known as cephalosporins. Cephalosporins are a set of antibiotics that are structurally and chemically related to penicillin.

Phexin 500 mg capsule is most effective against gram-positive bacteria, including Streptococcus, Staphylococcus, and some strains of Enterococcus. It is also active against gram-negative bacteria, including E. coli (Escherichia coli) and Klebsiella pneumoniae. However, it is ineffective against all strains of bacteria and may not be effective against antibiotic-resistant strains of bacteria.

Phexin 500 mg capsule can occasionally result in well-known adverse effects. Most of these adverse effects go away gradually without needing medical care. However, you contact your doctor if you experience these side effects frequently.

It is vital to use antibiotics judiciously and only when necessary, under the guidance of a healthcare provider. Additionally, individuals should always complete the entire course of treatment as prescribed, even if symptoms improve before the medication is finished.

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Respiratory infections: Phexin 500 mg capsule is commonly used to treat bacterial infections of the nose, throat, and lungs, such as sinusitis, pharyngitis, tonsillitis, bronchitis, and pneumonia. It is effective against several gram-positive and gram-negative bacteria that can cause these infections.
Ear infections: Phexin 500 mg capsule treats middle ear bacterial infections, known as otitis media. This type of infection is common in children, and Phexin is effective against many bacteria that can cause it.
Bone and joint infections: Phexin 500 mg capsule can treat bacterial infections of the bone and joint, such as osteomyelitis and septic arthritis. These infections can be severe and require prompt treatment with an appropriate antibiotic.
Skin infections: Phexin 500 mg capsule treats various skin infections caused by susceptible bacteria, including cellulitis, impetigo, and folliculitis. It is effective against many gram-positive bacteria that commonly cause these infections.
Urinary tract infections: Phexin 500 mg capsule treats uncomplicated urinary tract infections caused by susceptible bacteria. It treats infections of the bladder and urethra, but it may not be effective against infections of the kidneys.
Prostate gland infections: Phexin 500 mg capsule can be used to treat bacterial infections of the prostate gland, known as prostatitis. It is effective against many bacteria that can cause this type of infection.
Reproductive system infections: Phexin 500 mg capsule is used to treat various bacterial infections of the reproductive system, such as bacterial vaginosis and pelvic inflammatory disease. It is effective against many of the bacteria that can cause these infections.

Directions for Use of Phexin 500mg Capsule 10

Phexin 500 mg capsules should be taken as your doctor recommends.
Swallow it as a whole with water after your meal to avoid stomach discomfort.
Do not cut, break or chew the medicine.
It would be best to take it at a fixed time for optimal results.

Phexin 500 mg capsule is administered orally, making it a convenient treatment option for patients.

Some common side effects associated with Phexin 500 mg capsules include

Diarrhoea is a common side effect of Phexin 500 mg capsules, as antibiotics can disrupt the average balance of bacteria in the gut, leading to diarrhoea. In most cases, the diarrhoea is mild and self-limiting, but in some cases, it can be severe and persistent. If you experience severe or bloody diarrhoea, contact your healthcare provider immediately.
Nausea and vomiting are also typical side effects of Phexin 500 mg capsules. You should contact your physician if you experience persistent or severe nausea and vomiting.
Indigestion and stomach pain are common side effects of Phexin 500 mg capsules. These side effects are usually mild and can resolve efficiently. However, you should contact your healthcare provider if you experience severe or persistent stomach pain.
Skin rashes are also a possible side effect of Phexin 500 mg capsules that range from mild to severe and may co-occur with itching, swelling, or blistering. Contact your healthcare provider immediately if you develop a skin rash while taking Phexin 500 mg capsules.

Managing the Side Effects:

Most side effects are temporary and generally harmless, which resolve on discontinuing Phexin 500 mg capsules. However, if you experience any serious side effects or worsening of any of the symptoms, please consult your doctor.

Phexin 500 mg capsule is a first-generation cephalosporin antibiotic that inhibits bacterial cell wall synthesis by deactivating one or more penicillin-binding proteins and preventing the peptidoglycan structure from getting cross-linked, ultimately leading to bacterial death. It effectively works against a wide range of gram-positive and gram-negative bacteria. Still, its use should be guided by a healthcare provider to prevent the development of antibiotic resistance.

Pregnancy

If you're pregnant, it's essential to consult with a healthcare provider before taking Phexin 500 mg capsules. Because there is limited data on its safety for pregnant women, it should only be used when necessary.

Breastfeeding

Phexin 500 mg capsule contains cephalosporins, which may be secreted in breast milk, and its safety in nursing mothers is unknown. Before taking Phexin 500 mg capsules while breastfeeding, it is best to consult with your doctor.

Alcohol

Alcohol should be avoided when taking Phexin 500 mg capsules because it may raise the risk of harmful effects such as dizziness and sleepiness.

Liver

Patients with liver problems might require a reduced dose of Phexin 500 mg capsules or may not be able to take it at all. It is important to inform a healthcare provider of any liver problems.

Kidney

Patients with kidney problems may require a lower dose of Phexin 500 mg capsules or may not be able to take it at all. It is crucial to inform a healthcare provider of kidney problems before taking Phexin 500 mg capsules.

Using Machines & Driving

Phexin 500 mg capsules may cause dizziness or drowsiness, affecting a patient's ability to operate machinery or drive. Patients should avoid these activities until they know how Phexin 500 mg capsules affect them.

Allergy

Patients allergic to cephalosporin or penicillin antibiotics should not take Phexin 500 mg capsules. It is crucial to inform a healthcare provider of known allergies before taking Phexin 500 mg capsules.

Children

Phexin 500 mg capsules can be used in children, but the dose may need to be adjusted based on the child's weight. Contacting a healthcare provider before giving Phexin 500 mg capsules to a child is essential.

Older Patients

Older patients (65 years and older) may be more sensitive to the effects of Phexin 500 mg capsules, requiring a lower dose or more frequent monitoring. It is essential to inform a healthcare provider of any age-related concerns before taking Phexin 500 mg capsules.

Drug-Drug Interactions

Here are some drug-drug interactions to be cautious of

Antibiotics: Phexin 500 mg capsule may interact with other antibiotics such as capreomycin, vancomycin, gentamicin, neomycin, tobramycin, and cefuroxime. The concomitant use of these antibiotics with a Phexin 500 mg capsule may increase the risk of nephrotoxicity and ototoxicity. Therefore, when taking these medications together, blood sugar and kidney function monitoring is recommended.
Antidiabetic: Phexin 500 mg capsule may interact with antidiabetic medications such as metformin. The concomitant use of Phexin 500 mg capsule with metformin may raise the risk of lactic acidosis, a rare but severe side effect. Therefore, blood sugar and kidney function monitoring is recommended when taking these medications together.
Diuretics: Phexin 500 mg capsule may interact with diuretics such as furosemide and bumetanide. The concomitant use of Phexin 500 mg capsule with these diuretics may increase the risk of kidney toxicity. Therefore, monitoring kidney function regularly when taking these medications together is essential.
Oral anticoagulants: Medication such as warfarin may prolong prothrombin time when combined with cephalosporins.
Typhoid vaccine: Antibacterial activity against salmonella typhi organisms may interfere with the immunological response to the live typhoid vaccine. The appropriate time should elapse between the administration of the last dose of the antibiotic and the live typhoid vaccine.

Drug-Food Interactions

There are no notable drug-food interactions with Phexin 500 mg capsule. However, when using Phexin 500 mg capsule, the following drug-food interactions have been documented:

Grapefruit juice: Along with Phexin 500 mg capsule, grapefruit juice may interact with other medications a person may be taking. Due to the presence of chemicals in grapefruit juice, some drugs may not be adequately metabolised, resulting in higher blood levels and a higher risk of adverse effects.
Zinc Supplements: Zinc can reduce cephalexin absorption in the body. As a result of this, cephalexin may become less effective in fighting infections. Separating zinc and cephalexin can prevent this interaction. Taking zinc or zinc-containing multivitamins at least 3 hours after taking cephalexin helps your body absorb it better.

Additionally, taking the Phexin 500 mg capsule with food is suggested to lower the possibility of gastrointestinal side effects.

Drug-Disease Interactions

There are certain disease conditions in which the use of Phexin 500 mg capsule may not be safe, or caution is required.

Colitis: Colitis is the inflammation of the colon's lining. Antibiotics such as Phexin 500 mg capsule can disrupt the normal gut flora, leading to an overgrowth of harmful bacteria like Clostridium difficile. This can cause a type of colitis called antibiotic-associated colitis or pseudomembranous colitis. Patients with a history of colitis or diarrhoea should use Phexin 500 mg capsule judiciously.
Seizure disorders: Patients with a history of seizure disorders such as epilepsy should use Phexin 500 mg capsule carefully, as it can lower the seizure threshold and raise the likelihood of seizures.
Dialysis: Phexin 500 mg capsule is mainly excreted by the kidneys. Patients with severe kidney dysfunction, including those on dialysis, should use the Phexin 500 mg capsule cautiously under the guidance of a healthcare provider.
Kidney and liver dysfunction: Patients with pre-existing kidney or liver dysfunction should use Phexin 500 mg capsule cautiously, as it can worsen the condition.

Daily Dose

The recommended daily dose of Phexin 500 mg capsule is once daily, with food, as directed by your doctor. The dosage may change based on individual factors such as the severity of the condition and response to treatment. It is essential to follow the suggested dosage and not exceed it without consulting your doctor.

Over Dose

If you or someone else takes excessive Phexin 500 mg capsules by accident, it is essential to take immediate medical attention from your doctor or nearby hospital. An overdose's symptoms include brain damage and may cause headache, dizziness and stomach upset.

Missed Dose

If you forgot to take the Phexin 500 mg capsule, take it as soon as you recall or contact your healthcare provider. If the time for the next dosage is close, skipping the missed one is recommended now and resume your regular dosage pattern. Never increase your dosage without consulting your doctor.

Store Phexin 500 mg capsules at room temperature (15-25ºC).
Please protect it from light and moisture.
Keep Phexin 500 mg capsules away from children.
Do not use the Phexin 500 mg capsule after the expiry date has passed.

Drink plenty of fluids: Staying hydrated when taking Phexin 500 mg capsules is essential to prevent complications such as kidney damage. Drinking plenty of water and fluids can also help alleviate side effects such as nausea and vomiting.
Avoid alcohol: Alcohol can interfere with the effectiveness of antibiotics and cause liver damage. Therefore, it is recommended to avoid alcohol while taking Phexin 500 mg capsules.
Good hygiene practices: Bacterial infections can spread quickly through poor hygiene practices. Therefore, it is vital to maintain good hygiene practices like washing hands regularly, covering mouth and nose while coughing or sneezing and avoiding contact with people who have contagious illnesses.
Exercise regularly: Regular exercise can help boost the immune system and promote overall health and well-being.
Well-balanced diet: Consume fibre-rich foods, such as whole grains, legumes, berries, broccoli, peas, and bananas.
Intake probiotics: Antibiotics may disrupt the beneficial bacteria in the stomach that aid digestion. As a result, probiotic-rich foods such as yoghurt/curd and buttermilk are recommended

Taking Phexin 500 mg capsules with food can help reduce the risk of stomach upset and indigestion.
It is essential to complete the duration of treatment as the healthcare provider prescribes.
Stopping the medication prematurely can lead to antibiotic resistance and increase the risk of recurrent infections.
Diarrhoea is a possible adverse effect of Phexin 500 MG Capsule, although it usually goes away once your treatment is over.

Fact Box

Drug Category	Cephalosporins: 1st generation
Therapeutic Category	Antibiotic
Available Dosage Types	Capsule
Habit Forming	No
Ailment	Bacterial infection

Is Phexin 500 mg capsules an antibiotic?

Yes, Phexin 500 mg capsules is an antibiotic medication in the cephalosporins class. Its active ingredient is cephalexin, which is a first-generation cephalosporin.

Is it safe to take Phexin 500 mg capsules?

Phexin 500 mg capsules are typically safe when taken as directed by a healthcare provider. However, it may cause side effects in some people, as with all medications. Following the dose recommendations and precautions indicated by the healthcare professional is critical to reduce the danger of side effects. It is advisable to inform your healthcare provider about any pre-existing medical conditions, medications, or allergies before commencing treatment with Phexin 500 mg capsules.

What is the recommended dose of Phexin 500 mg capsules?

The standard recommended dose of Phexin 500 mg capsule is one to two capsules taken orally every six to twelve hours with food, depending on the severity of the infection. The dosage may vary depending on the patient's age, weight, renal function, and the type and severity of the treated infection. It is essential to follow a healthcare provider's instructions and complete the course of treatment as prescribed.

At what age can you take Phexin 500 mg capsules?

Adults and children over one year can take Phexin 500 mg capsule. Before taking the Phexin 500 mg capsule, visit your doctor if you have kidney, liver, or cardiac issues.

Can I take Phexin 500 mg capsules for a toothache?

Phexin 500 mg capsules can treat bacterial infections such as respiratory tract infections, skin and soft tissue infections, urinary tract infections, and bone and joint infections. However, it is not specifically indicated for the treatment of toothache. If you are experiencing tooth pain, seeing a dentist who can correctly diagnose and treat the underlying cause is essential.

How long does it take for Phexin 500 mg capsules to work?

The duration of treatment with Phexin 500 mg capsules will depend on the type and severity of the infection being treated. The prescribing healthcare provider will determine the duration of therapy based on various factors such as the site of infection, bacterial susceptibility, and patient response. Treatment with Phexin 500 mg capsules usually takes a few days to several weeks. It is crucial to complete the entire course of treatment as prescribed, even if the symptoms improve before the completion of the treatment course.

Can Phexin 500 mg capsules damage kidneys?

Is Phexin 500 mg capsules safe in pregnancy?

Is Phexin 500 mg capsules safe for breastfeeding?

Phexin 500 mg capsule is secreted in breast milk, and its safety in nursing mothers is unknown. Before taking Phexin 500 mg capsules while breastfeeding, it is best to consult with your doctor.

Last Updated On 17 Feb. 2024 | 1:40PM (IST)

Certified Content

Written by

Dr. Sachin Singh

Medical Team Lead | 5 years

MBBS

Reviewed by

Dr. Mandeep Chadha

Lead Medical Content Reviewer | 10 years

MBBS, DNB (OBGY)

Check out Editorial Policy

References

K.D. Tripathi. Antimicrobial Drugs. Essentials of Medical Pharmacology. 8th edition. 2019. Page 776.
Patient information. (n.d.). Retrieved February 17, 2024, from https://india-pharma.gsk.com/media/6398/phexin-oral-formulations.pdf

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