Hyponat O 15 Mg Tablet 10

Hyponat O 15 Tablet 10

Zydus Cadila

Strip of 10 Units

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Composition

Tolvaptan (15 Mg)

Strength:

30 MG 15 MG

Hyponat-O 15 Tablet is primarily used to manage hyponatremia, a condition marked by abnormally low levels of sodium in the blood. This medicine is part of a group known as vasopressin antagonists.

Besides its main use, this tablet is also beneficial in clinical settings such as heart failure, liver cirrhosis, and the syndrome of inappropriate antidiuretic hormone (SIADH). These conditions often contribute to the development of hyponatremia and can be effectively managed with this medication.

You should always take this medication as directed by your doctor. Inform your doctor about your medical history and any ongoing medications you might be taking. If you experience any side effects during the course of your treatment, consult your doctor right away. To achieve optimal results, it's crucial to continue the medication for the duration prescribed by your doctor.

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Hyponat-O 15 Tablet is used for the following:

Correcting low sodium levels in the blood, known as hyponatremia.
Managing hyponatremia (associated with heart failure), where the heart can't pump enough blood to meet the body's needs.
Addressing the imbalance of sodium in individuals suffering from liver cirrhosis, a condition where healthy liver tissue is replaced with scar tissue.
Restoring normal sodium levels in patients with Syndrome of Inappropriate Antidiuretic Hormone (SIADH), a condition where excessive amounts of antidiuretic hormone are released, resulting in water retention and low sodium levels.

Directions for Use of Hyponat O 15 Tablet 10

Here's how you should take Hyponat-O 15 Tablet:

Always stick to the dose recommended by your doctor.
Stick to the diet prescribed by your doctor during the entire course of this medicine.
Do not discontinue the medicine if it is not directed by your doctor.

Hyponat-O 15 Tablet is taken orally.

While taking Hyponat-O 15 Tablet, you may experience the following side effects:

Dry mouth and increased thirst
Constipation and nausea
Frequent urination and nocturia: You could find yourself needing to urinate often, even more so during the night.
Hyperkalemia: This is where your blood has higher than normal levels of potassium.
Elevated blood creatinine: This means that there is a higher level of a waste product called creatinine in your blood.

Managing the Side Effects:

Most side effects are temporary and generally harmless, which resolve on discontinuing the use of Hyponat-O 15 Tablet. However, if you experience any serious side effects or worsening of any of the symptoms, please consult your doctor.

Frequent urination and nocturia: You might find it helpful to take this medicine in the morning to limit night-time bathroom visits.
Nausea: Try taking Hyponat-O 15 Tablet with or after meals to manage this side effect.

Hyponat-O 15 Tablet contains Tolvaptan (15 mg), which works on your body in several ways:

Vasopressin V2 Receptor Antagonist: Tolvaptan acts as a selective vasopressin V2 receptor antagonist. Vasopressin is a hormone that controls the balance of water in your body by promoting water reabsorption in your kidneys.
Increases Free Water Clearance: By blocking the action of vasopressin on V2 receptors, Tolvaptan reduces water retention and increases free water clearance from your body.
Promotes Aquaresis: The increased water clearance leads to a condition called aquaresis, which is an increase in urine output without significant changes in electrolyte excretion.
Raises Serum Sodium Levels: With excess water being eliminated from your body through urine, there's a gradual increase in serum sodium concentration, helping correct hyponatremia.

Pregnancy

Hyponat-O 15 Tablet is not recommended during pregnancy due to possible risks. It's wise to consult your doctor before taking this medicine when pregnant.

Breastfeeding

Caution is advised while taking Hyponat-O 15 Tablet during the breastfeeding period. Inform your doctor and do as you are prescribed.

Alcohol

Caution is advised while taking Hyponat-O 15 Tablet and consuming alcohol to avoid any adverse effects. It's best to discuss this with your doctor.

Liver

For those with mild liver issues, caution is recommended when taking Hyponat-O 15 Tablet. This medicine is not recommended for severe liver diseases. Discuss any liver concerns with your doctor before starting the medication.

Kidney

If you have a history of kidney issues, be cautious when using Hyponat-O 15 Tablet. It's important to consult your doctor and maintain regular check-ups of your kidney function while on this medication.

Using Machines & Driving

Hyponat-O 15 Tablet does not usually affect one's ability to drive or operate machinery. However, if you experience side effects that might impair these abilities, avoid driving and machine operation until those effects subside.

Allergy

If you are allergic to tolvaptan or any other components of Hyponat-O 15 Tablet, do not take this medicine. Consult your doctor about any allergies you may have before starting this medication.

Children

Caution is advised when giving Hyponat-O 15 Tablet to children under 18 years of age. Always consult your doctor before giving any medicine to a child.

Older Patients

Older patients should take Hyponat-O 15 Tablet under medical supervision, as they may be more susceptible to its side effects. Caution is advised if patients are over 70 years of age. Your doctor will guide you based on your health status.

Drug-Drug Interactions

Hyponat-O 15 Tablet interacts with the following medicines:

Strong CYP3A inhibitors: Medications like ketoconazole and clarithromycin may increase the levels of tolvaptan in your body.
Strong CYP3A inducers: Medicines such as rifampin can decrease the levels of tolvaptan in your system.
Diuretics: Medicines that increase urine output, like furosemide or hydrochlorothiazide, may enhance the water-eliminating effect of Hyponat-O 15 Tablet and increase the risk of dehydration.
Vasopressin analogues: Medicines like desmopressin can counteract the effects of Hyponat-O 15 Tablet.

Drug-Food Interactions

There are no specific food items that interact with Hyponat-O 15 Tablet. Seek advice from your doctor if you have doubts.

Drug-Disease Interactions

Hyponat-O 15 Tablet interacts with the following diseases:

Liver disease: If you have a liver condition, using Hyponat-O 15 Tablet could worsen your situation.
Renal impairment: The efficiency of Hyponat-O 15 Tablet may be reduced if you have kidney disease.

Daily Dose

For Hyponat-O 15 Tablet, strictly follow your doctor's prescription. The prescribed amount may differ from person to person based on the severity of the condition and how you respond to it. Always stick to the prescribed dosage, and never increase it without consulting your doctor.

Over Dose

If you accidentally take more Hyponat-O 15 Tablet than prescribed, you may experience overdose effects like dry mouth or increased thirst more severely. Should such symptoms persist or worsen, please inform your doctor.

Missed Dose

If you missed a dose of Hyponat-O 15 Tablet take it as soon as you remember. But if it's nearly time for your next dose, skip the forgotten one and continue with your regular schedule. Never alter your dosage without discussing it with your doctor.

Store your Hyponat-O 15 Tablet at room temperature, ideally between 15 and 30°C.
Keep this medicine in a tightly closed container, away from direct sunlight and moisture.
Ensure the medicine is kept out of reach of children.
Always check the expiration date before taking the tablet.

If you have heart failure or liver cirrhosis, try to limit your salt intake. This can help manage your body's fluid balance.
Stay hydrated, but avoid excessive water intake. Hyponat-O 15 Tablet corrects low sodium levels by promoting water excretion; drinking excess water may counteract its effects.

Fact Box

Drug Category	Vasopressin V2 Antagonist
Therapeutic Category	Hyponatremia Management
Available Dosage Types	Tablet
Habit Forming	No
Ailment	Heart Failure, Cirrhosis, and SIADH

What is Hyponat-O 15 Tablet used for?

Hyponat-O 15 Tablet is used to manage hyponatremia, a condition where sodium levels in the blood are abnormally low. It's typically seen in heart failure, liver cirrhosis, and SIADH.

How does Hyponat-O 15 Tablet work?

Hyponat-O 15 Tablet contains tolvaptan which blocks vasopressin activity, a hormone that controls water balance. This results in more water being eliminated from the body through urine and increased sodium levels.

Can Hyponat-O 15 Tablet be used by patients with kidney disease?

Patients with mild to moderate kidney issues can use Hyponat-O 15 Tablet with caution. However, it's not recommended for those with severe kidney impairment or in patients with an inability to pass urine.

What should I do if I miss a dose of Hyponat-O 15 Tablet?

If you miss a dose, take it when you remember. But if it's near the time for your next dose, skip the missed one and continue your regular schedule. Don't double up.

Can I take Hyponat-O 15 Tablet while pregnant or breastfeeding?

It's advised not to take Hyponat-O 15 Tablet during pregnancy or breastfeeding due to potential risks. Always consult your doctor before starting any new medication during these periods.

What are the common side effects of Hyponat-O 15 Tablet?

Common side effects include frequent urination, dry mouth, increased thirst, constipation and nausea. If you experience these persistently or severely, consult your doctor immediately.

How should I store my Hyponat-O 15 Tablets?

Store your tablets at room temperature (between 15-30°C), in a tightly closed container, protected from light and moisture. Keep them out of reach of children.

Certified Content

Written by

Dr. Michelle Frank

Medical Content Writer | 8 years

Doctor of Medicine

Reviewed by

Dr. Chhavi Rosha

Health & Medical Content Writer | 8 years

BMS, FMC, MD Resident

Check out Editorial Policy

References

U.S. Food and Drug Administration. (2018). NDA 204441 S-000 Chemistry Review(s). Retrieved 1 April 2024, from https://www.accessdata.fda.gov/drugsatfda_docs/nda/2018/204441Orig1s000ChemR.pdf
Tolvaptan: Uses, interactions, mechanism of action | DrugBank Online. (n.d.). DrugBank. https://go.drugbank.com/drugs/DB06212
Kim, Y., & Han, S. (2023). Recent updates in therapeutic approach using tolvaptan for autosomal dominant polycystic kidney disease. The Korean Journal of Internal Medicine/Korean Journal of Internal Medicine, 38(3), 322–331. https://doi.org/10.3904/kjim.2022.376
Oporto, F. R., Gómez, C. A., Cosano, G. M., Aguilera, A. L., & Rocha, J. L. (2024). Prospective Study on Individualized Dose Adjustment of Tolvaptan Based on Urinary Osmolality in Patients with Autosomal-dominant Polycystic Kidney Disease. Kidney International Reports. https://doi.org/10.1016/j.ekir.2024.01.020

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