Domperidone + Rabeprazole
ANTIEMETIC/ANTACIDUses of Domperidone + Rabeprazole
- Domperidone + Rabeprazole are used to treat symptoms of acid reflux caused by hyperacidity, stomach ulcers (peptic ulcer disease), and Zollinger-Ellison syndrome (a condition characterized by excessive acid production due to a pancreatic tumor). Additionally, they are used short-term to manage symptoms of gastroesophageal reflux disease (GERD).
Side effects of Domperidone + Rabeprazole
The side effects of Domperidone + Rabeprazole are:
- Sore throat
- Cough
- Abdominal pain
- Diarrhoea
- Flatulence
- Weakness
- Muscle pain
- Dizziness
How Domperidone + Rabeprazole works
- Domperidone is a medication that helps prevent nausea and vomiting by acting on the stomach and intestines. It does not easily cross into the brain, so serious side effects like those affecting movement are very rare in adults. However, it can increase the levels of prolactin, a hormone from the pituitary gland. Its effectiveness in stopping nausea comes from its actions in the stomach and its ability to block dopamine receptors in a part of the brain that helps control vomiting.
- Rabeprazole is classified as an antisecretory agent, specifically a substituted benzimidazole proton-pump inhibitor. It works by blocking a specific enzyme in the stomach that produces acid. This enzyme, called the H+ and K+ ATPase, is responsible for releasing acid into the stomach. By stopping this enzyme, rabeprazole effectively reduces the amount of stomach acid produced, helping to treat conditions caused by excess acid.
Certified content
Written By
B. Pharm
Reviewed By
B. Pharm, MSc.
Expert Advice
Dosage Forms Available for Domperidone + Rabeprazole
- This combination is available for use via the oral route (delayed-release tablets and capsules).
Age And Dosage Restrictions for Domperidone + Rabeprazole
- This combination is meant for adults and children above 18 years of age.
Contraindications of Domperidone + Rabeprazole
- Domperidone + Rabeprazole is contraindicated in patients with known allergies to domperidone or rabeprazole, and in patients who have prolactinoma and severe liver issues.
Medications To Avoid With Domperidone + Rabeprazole
- It is contraindicated to concurrently use anticoagulants (clopidogrel, warfarin), azole antifungals (ketoconazole, voriconazole, itraconazole, posaconazole), nucleoside reverse transcriptase inhibitors (atazanavir, amprenavir, nelfinavir), antacids (magnesium hydroxide, aluminium hydroxide, cimetidine), iron supplements, antibiotics (clarithromycin, erythromycin, ampicillin, rifampicin), cardiac medications (atropine, digoxin, amiodarone), antihypertensive agents (diltiazem), antineoplastic medications (methotrexate), and antiemetic medications (aprepitant) in combination with Domperidone + Rabeprazole. Consultation with a doctor is imperative before initiating any prescription or over-the-counter medications.
Overdose and Missed Dose
- Overdose of this combination can cause agitation, altered consciousness, convulsions, disorientation, somnolence, and extrapyramidal reactions. Inform your doctor regarding these effects and follow the advice accordingly.
- If you forget to take this combination, take it as soon as you remember, but avoid repeating the dose.
Use In Driving And Operating Machinery
- This combination may affect your ability to drive or operate heavy machinery. Avoid driving if you feel dizzy after taking this combination.
Use in Pregnancy and Lactation
- This combination is not recommended during pregnancy or breastfeeding.
Special Dietary & Lifestyle Recommendation
- Avoid alcohol when you are taking Domperidone + Rabeprazole.
- Individuals with gastroesophageal reflux disease should contemplate lifestyle adjustments, incorporating dietary modifications such as adopting a GERD-friendly diet characterised by an emphasis on low-acid foods, avoidance of spicy and fatty meals, and reduction of portion sizes, all in conjunction with the administration of Domperidone + Rabeprazole.
- It is best to take this combination before meals.
Frequently asked questions
1. How much time does Domperidone + Rabeprazole take to work?
This combination starts showing its effect within a few hours after consumption.
2. What warnings and precautions should I take while taking Domperidone + Rabeprazole?
Avoid taking this combination if you experience hypersensitivity or allergic reactions to any of its components. Promptly seek medical advice in such cases.
3. Can I stop taking Domperidone + Rabeprazole if I feel healthy?
Do not stop taking this combination without consulting your doctor, even if you feel healthy.
4. Is it safe for patients with kidney or liver issues?
Consult your doctor before taking this combination if you have kidney or liver issues to ensure its safety and proper dosage.
5. Can the use of Domperidone + Rabeprazole cause abnormal heartbeat?
The use of Domperidone + Rabeprazole can, in rare cases, cause abnormal heartbeat or other heart-related side effects. Domperidone has been associated with an increased risk of heart rhythm disturbances. If you experience any unusual heart symptoms, consult your healthcare provider immediately.
6. Can you take Domperidone + Rabeprazole on an empty stomach?
Domperidone + Rabeprazole can generally be taken on an empty stomach, but it is often recommended to follow the specific instructions provided by your healthcare provider. Taking Rabeprazole with or without food can affect its absorption, so adhere to the guidance given to ensure optimal effectiveness.
7. Is Domperidone + Rabeprazole safe for kidneys?Â
Domperidone + Rabeprazole is usually safe for kidney function when used as prescribed. However, if you have pre-existing kidney conditions, it's important to consult your doctor before starting this combination. They may need to monitor your kidney function regularly to ensure there are no adverse effects.
Domperidone + Rabeprazole in other salts
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