Domperidone
ANTIEMETICUses of Domperidone
- Domperidone is used to prevent nausea and vomiting caused by various conditions, medications, or surgery.
- It also helps treat gastroparesis, where a person feels full and bloated after eating only a small amount.
- Additionally, domperidone can be used to increase breast milk production.
Side effects of Domperidone
The side effects of Domperidone are:
- Dry mouth
- Diarrhoea
- Headache
- Somnolence
- Drowsiness
How Domperidone works
Domperidone is an antiemetic and a prokinetic drug . Here’s domperidone’s mechanism of action:
- It tightens the muscles at the top of the stomach and relaxes the muscles at the bottom, reducing the likelihood of vomiting.
- It acts as a dopamine antagonist by blocking dopamine receptors in the chemoreceptor trigger zone (an area in the brain associated with vomiting) and the gut.
- By blocking dopamine receptors, it effectively reduces nausea and vomiting.
- It Improves the movement of food through the digestive tract.
Certified content
Written By
B. Pharm
Reviewed By
B. Pharm, MSc.
Expert Advice
Dosage Forms Available
- Domperidone is available for use via the oral route (tablet, drops and suspension), rectal route (Suppositories).
Age And Dose Restrictions
- It can be used for both adults and children above 12 years of age.
Contraindications
- Domperidone is contraindicated in patients with irregular heartbeats, moderate to severe liver impairment, and electrolyte disturbances, as it can aggravate these conditions.
Medications To Avoid With This Drug
- Avoid taking antiarrhythmic medication and antihypertensives with Domperidone as it can increase the risk of irregular heartbeats when used together.
Overdose And Missed Dose
- Overdose can increase the possibility of abnormal heart rhythm (arrhythmias). You may feel sleepy, confused, and show uncontrolled movements, including unusual eye movements, tongue movements or abnormal posture, which needs to be managed as an emergency in a hospital setting. Therefore, strict adherence to the prescribed dose is essential.
- If you happen to miss a dose of Domperidone, take it as soon as you remember. But, if the time for the next dose is near, skip the missed and resume the regular dosing regime.
Management Of Side Effects
- Take this medicine with food to reduce gastrointestinal side effects and continue taking it as prescribed. If side effects worsen or persist, consult your doctor for a possible treatment plan adjustment.
Use In Driving And Operating Machinery
- It is better to avoid driving or operating heavy machinery while on Domperidone as it has been reported to cause sleepiness, uncontrolled movements and irregular heartbeats.
Use In Pregnancy And Lactation
- It should be used with caution in pregnant and breastfeeding women.
Caution In Other Conditions
- Caution is advised in elderly patients with heart problems and liver dysfunction.
Special Dietary And Lifestyle Recommendation
- To get the most benefit from Domperidone, it's often best to take it about 15 to 30 minutes before your meals.It helps improve its effectiveness in promoting stomach and intestinal movement, which is particularly important if you're taking it for digestive issues.
- Avoid high-fat meals while on Domperidone. High-fat foods can slow down digestion and may counteract the medication's effects.
- The maximum treatment duration with Domperidone should not usually exceed one week. If nausea and vomiting does not improve within a week, inform your doctor.
Frequently asked questions
1. How much time does Domperidone take to work?
Domperidone typically starts working within 30 minutes to 1 hour after taking it.
2. Which medications should be avoided while taking Domperidone?
Avoid medications like antiarrhythmics like amiodarone, antifungals like ketoconazole,fluconazole and antibiotics like erythromycin when taking Domperidone, as they can lead to dangerous arrhythmias.
3. Should I stop taking Domperidone if I feel good?
Don't stop taking Domperidone without consulting your doctor, even if you feel better.
4. Is Domperidone a habit forming medicine?
Domperidone is not habit-forming and is generally safe when used as directed.
5. Is it safe to drink alcohol while taking Domperidone?
It's best to avoid alcohol while taking Domperidone, as it can increase the risk of side effects.
6. Does Domperidone affect fertility?
Domperidone doesn't typically affect fertility, but consult your doctor for personalised advice.
7. Is Domperidone available over the counter, or do I need a prescription?
Domperidone usually requires a prescription and is not available over the counter.
8. What should I do if I miss a dose of Domperidone?
If you miss a dose of Domperidone, take it as soon as you remember, but do not double the next dose.
9. What should I do if I experience any unusual or severe side effects while using Domperidone?
Contact your doctor if you experience unusual or severe side effects while using Domperidone for guidance and potential adjustments to your treatment.
10. Is domperidone used for acidity?
Yes, Domperidone is used to manage symptoms related to acidity, such as nausea and vomiting. It can also help with discomfort caused by slow stomach movement (gastroparesis) and indigestion.
11. Is domperidone good for bloating?
Yes, Domperidone can relieve symptoms of bloating and fullness. It works by increasing the movement of food through the stomach and intestines, reducing feelings of bloating and indigestion.
12. Who cannot take domperidone?
Domperidone may not be suitable for people who have had an allergic reaction to it or any other medicine, who weigh less than 35 kg or have conditions like Crohn’s disease, diverticulitis, bleeding from the stomach or gut, or a tumor on the pituitary gland. Older adults over 60 years old are also not recommended this medicine due to increased risk of side effects. Those with heart problems and liver dysfunction should also cautiously take this medicine.
13. What is the mechanism of action of domperidone?
Domperidone acts as a gastrointestinal emptying adjunct and peristaltic stimulant. It blocks dopamine receptors in the gut, increasing gastric motility and helping food move more quickly through the digestive tract. It also affects the chemoreceptor trigger zone in the brain, which is involved in nausea and vomiting.
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