Gliptagreat D 10100 Mg Tablet 10

Gliptagreat D10 Tablet 10

Mankind Pharmaceuticals Ltd.

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Composition

Dapagliflozin (10 Mg) + Vildagliptin (100 Mg)

Gliptagreat D10 Tablet is primarily used for managing type 2 diabetes mellitus in adults. It's a combination medicine that falls under the category of oral antidiabetic medications.

In addition to its main use, this medication also assists in managing kidney disease or heart failure in individuals with type 2 diabetes mellitus, potentially reducing the risk of death from heart disease and minimising hospitalisations for heart failure.

You should take this medication as your doctor directs. Before taking this medicine, let your doctor know about any pre-existing conditions or ongoing medications you may have. If you notice any side effects while on this medicine, inform your doctor immediately. Ensure you continue taking the medicine for the prescribed duration for optimal results.

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Gliptagreat D10 Tablet is used for the following:

Managing blood sugar levels in adults with type 2 diabetes mellitus
Assisting in glycemic control when metformin alone doesn't work
Lowering the risk of death from heart disease in people with type 2 diabetes
Reducing hospitalisations due to heart failure in individuals who also have type 2 diabetes
Providing renal support and managing kidney disease in those living with type 2 diabetes

Directions for Use of Gliptagreat D10 Tablet 10

Here are some simple steps to follow while taking Gliptagreat D10 Tablet:

Thoroughly follow the dosage and timing guidelines provided by your doctor for taking this medicine.
Do not change or exceed the prescribed dose without consulting your doctor.
Avoid discontinuing this medication without your doctor's advice. Always consult your doctor before stopping.
Adhere to the diet plan recommended by your doctor.

Gliptagreat D10 Tablet is taken orally.

Side Effects of Gliptagreat D10 Tablet 10

You may experience the following side effects after taking Gliptagreat D10 Tablet:

Genital yeast infections: This refers to a fungal infection that can cause itching, redness and discharge in men and women.
Urinary tract infections
Hypoglycaemia: This is when your blood sugar levels fall below normal, causing symptoms like dizziness, fatigue, and hunger.
Back pain
Joint pain
Increased urination and thirst

Managing the Side Effects:

Most side effects are temporary and generally harmless, which resolve on discontinuing the use of Gliptagreat D10 Tablet. However, if you experience any serious side effects or worsening of any of the symptoms, please consult your doctor.

Here are a couple of guidelines for managing common side effects:

Genital yeast infections: Keep the genital area clean and dry to prevent infections.
Hypoglycaemia: Monitor your blood sugar levels regularly, especially if you feel dizzy or hungry often.

Gliptagreat D10 Tablet includes two active ingredients:

Dapagliflozin (10 mg): This is a sodium-glucose cotransporter-2 (SGLT2) inhibitor. It works by blocking your kidneys from reabsorbing glucose, making you excrete excess glucose through urine, which helps reduce blood sugar levels.
Vildagliptin (100 mg): This ingredient is a dipeptidyl peptidase-4 (DPP-4) inhibitor. It increases the levels of incretins such as glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP). Incretins are compounds that help control blood sugar by stimulating insulin secretion after meals and reducing glucagon production in the liver.

Pregnancy

This medicine is contraindicated during pregnancy. If you are pregnant or planning to conceive, make sure to discuss this with your doctor before starting Gliptagreat D10 Tablet.

Breastfeeding

Caution is advised while taking Gliptagreat D10 Tablet if you are breastfeeding. It is best to consult your doctor before taking this medicine.

Alcohol

Consuming alcohol while taking Gliptagreat D10 Tablet could interfere with the medicine's effectiveness and could lead to an increased risk of side effects. It's wise to limit alcohol consumption while taking this medicine.

Liver

Caution is advised when taking Gliptagreat D10 Tablet if you have mild to moderate liver impairment. This medicine may affect liver function, so discuss your liver health with your doctor before starting.

Kidney

Gliptagreat D10 Tablet should be used with caution if you have a history of kidney problems. Discuss any kidney-related concerns with your doctor before starting this medication.

Using Machines & Driving

Gliptagreat D10 Tablet may cause dizziness or fatigue, which could affect your ability to drive or operate machinery. Be aware of how you react to the medicine before engaging in these activities.

Allergy

If you have a known allergy to dapagliflozin, vildagliptin, or any other components in Gliptagreat D10 Tablet, avoid using it. Always inform your doctor about your allergic reactions before starting new medication.

Children

Gliptagreat D10 Tablet is not recommended for use in children under 18 years of age. Always consult your doctor before administering any medication to a child.

Older Patients

Older patients should take Gliptagreat D10 Tablet under medical supervision as they may be more susceptible to its side effects. Your doctor will guide you based on your health status, especially if you are above 70 years of age or have liver and kidney issues.

Interactions of Gliptagreat D10 Tablet 10

Drug-Drug Interactions

Gliptagreat D10 Tablet interacts with the following medicines:

Insulin and insulin secretagogues: Medicines like glimepiride, gliclazide, or glipizide can increase the risk of low blood sugar levels (hypoglycaemia) when used with Gliptagreat D10 Tablet.
Diuretics: Taking medicines like furosemide, hydrochlorothiazide, or spironolactone with Gliptagreat D10 Tablet can lead to dehydration and a drop in blood pressure (hypotension).
Calcium channel blockers: Medicines like nifedipine may interact with Gliptagreat D10 Tablet to increase the risk of hypotension and swelling (oedema).

Drug-Food Interactions

There are no specific food interactions with Gliptagreat D10 Tablet.

Drug-Disease Interactions

Gliptagreat D10 Tablet interacts with the following diseases:

Renal impairment: Patients with severe kidney disease should avoid this medication as it could worsen their condition.
Pancreatitis and gallstones: Patients with a history of pancreatitis or gallstones need to exercise caution as Gliptagreat D10 Tablet could exacerbate these conditions.
Metabolic acidosis and diabetic ketoacidosis: It is not recommended for use in patients with acute or chronic metabolic acidosis or diabetic ketoacidosis.

Daily Dose

It's essential to take your daily dose of Gliptagreat D10 Tablet as prescribed by your doctor. The dosage can vary based on individual factors like the severity of your condition and how you respond to treatment. Always follow the dosage instructions given by your doctor, and don't exceed it without consulting your doctor.

Over Dose

If you accidentally take more Gliptagreat D10 Tablets than prescribed, you may experience side effects such as dizziness, headache, or nausea. If these symptoms persist or worsen, it's important to inform your doctor.

Missed Dose

If you forget to take your Gliptagreat D10 Tablet as instructed, take it as soon as you remember. However, if it's nearly time for your next dose, skip the missed one and continue with your regular dosage schedule. Don't increase your dose without consulting your doctor.

Keep Gliptagreat D10 Tablet in its original packaging.
Store at room temperature, ideally between 20°C to 25°C.
Protect from exposure to light and moisture.
Ensure the medicine is out of reach of children.
Always use Gliptagreat D10 Tablet before its expiry date.

Incorporate a balanced, low-sugar diet into your lifestyle as Gliptagreat D10 Tablet is used to manage type 2 diabetes mellitus. This will help in maintaining your blood sugar levels.
Regular physical activity, such as walking or yoga, is encouraged as it helps manage blood sugar levels and improves the effectiveness of the medicine.

Fact Box

Drug Category	SGLT2 Inhibitor, DPP-4 Inhibitor
Therapeutic Category	Antidiabetic
Available Dosage Types	Tablet
Habit Forming	No
Ailment	Type 2 Diabetes Mellitus, Heart Failure, Kidney Disease

What is the Gliptagreat D10 Tablet used for?

Gliptagreat D10 Tablet is used primarily to manage blood sugar levels in adults with type 2 diabetes mellitus.

How does Gliptagreat D10 Tablet work?

The tablet contains dapagliflozin and vildagliptin, which work together to lower blood sugar levels by promoting glucose excretion and increasing insulin secretion.

How should I take the Gliptagreat D10 Tablet?

You must take the medicine exactly as prescribed by your doctor.

Can the Gliptagreat D10 Tablet cause side effects?

Yes, it can cause side effects like yeast infections, urinary tract infections, low blood sugar, and nausea.

When should I avoid taking the Gliptagreat D10 Tablet?

You should avoid this medicine if you have severe kidney impairment, metabolic acidosis, diabetic ketoacidosis or are allergic to any components of the tablet.

Can this medicine interact with other medications?

Yes, it may interact with insulin, diuretics, nifedipine and certain cationic medicines. Always inform your doctor about all your medications.

How should I store Gliptagreat D10 Tablet?

Store it at room temperature between 20°C to 25°C, protected from light and moisture, in its original container.

Certified Content

Written by

Dr. Sachin Singh

Medical Team Lead | 5 years

MBBS

Reviewed by

Dr. Mandeep Chadha

Lead Medical Content Reviewer | 10 years

MBBS, DNB (OBGY)

Check out Editorial Policy

References

AstraZeneca. (2014). HIGHLIGHTS OF PRESCRIBING INFORMATION [Press release]. https://www.accessdata.fda.gov/drugsatfda_docs/label/2020/202293s020lbl.pdf
Dapagliflozin: Uses, interactions, mechanism of action | DrugBank Online. (n.d.). DrugBank. https://go.drugbank.com/drugs/DB06292
NVR & FB. (2020). Galvus. In Galvus (pp. 1–19). https://www.novartis.com/sg-en/sites/novartis_sg/files/Galvus-Jul2020.SIN-App051120.pdf
Vildagliptin: Uses, interactions, mechanism of action | DrugBank Online. (n.d.). DrugBank. https://go.drugbank.com/drugs/DB04876
Joshi, A., Birla, A., Prasad, A., & Warrier, S. (2022). Bioequivalence study of a fixed-dose combination of Dapagliflozin/ Vildagliptin Sustained Release tablets in healthy adult male subjects: A Randomized, Open-Label, Crossover Study. Journal of Drug Delivery and Therapeutics, 12(6), 105–109. https://doi.org/10.22270/jddt.v12i6.5798

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