Metformin + Pioglitazone + Sitagliptin

Dosage Forms Available

• Metformin + Pioglitazone + Sitagliptin is available for use in the form of oral tablets.

Age and Dose Restrictions

• This medication is primarily designed for adults with type 2 diabetes mellitus. It is contraindicated for use in children.

Contraindications

• The medicine is contraindicated in patients with severe renal impairment, metabolic acidosis, including diabetic ketoacidosis.
• It should not be used by people who have known allergies to any of the three individual components: Metformin, Pioglitazone, or Sitagliptin.

Other Medications to Avoid

• Metformin + Pioglitazone + Sitagliptin can interact with carbonic anhydrase inhibitors (such as topiramate and zonisamide), cytochrome P450 2C8 inhibitors (such as gemfibrozil and trimethoprim), and digitalis medicines (such as digoxin).
• Therefore, before starting any other medications, it is essential to consult your doctor.

Overdose and Missed Dose

• An overdose of this medication may cause symptoms such as nausea, vomiting, diarrhoea, abdominal pain, and hypoglycemia. If anyone experiences these symptoms after taking more than the recommended dose, they should seek medical attention immediately.
• If you forget to take a dose of this medicine, take it as soon as you remember. However, if it is nearly time for the next dose, skip the missed dose. Never double up on a dose to compensate for a missed one.

Management of Side Effects

Most side effects are temporary and generally harmless, resolving when discontinuing this medicine. However, if you experience any severe side effects or worsening of any symptoms, please consult your doctor.

• To manage side effects like nausea and vomiting, try taking the medication with food.
• Drinking plenty of fluids can help manage diarrhoea and prevent dehydration.

Use in Driving and Operating Machinery

• This medicine may cause dizziness or drowsiness. It is advised not to drive or operate heavy machinery if you experience these side effects.

Use in Pregnancy and Lactation

• It is advised to consult your doctor before using Metformin + Pioglitazone + Sitagliptin during pregnancy or while breastfeeding.

Caution in Other Conditions

• Care should be taken in patients with renal diseases as this medication is contraindicated in severe renal impairment.
• It should also be used with caution in patients with hepatic diseases due to possible changes in medicine metabolism.

Special Dietary and Lifestyle Recommendations

• People living with type 2 diabetes mellitus should strive to maintain a balanced diet that is low in saturated fats, trans fats, cholesterol, salt, and added sugars.
• Regular physical activity, such as walking or cycling, can also help manage blood sugar levels.
• Avoid excessive intake of alcohol as it may increase the risk of lactic acidosis with Metformin.
• Regularly monitor blood glucose levels as directed by your doctor.