Mesna
Uses of Mesna
The primary use of Mesna is to manage haemorrhagic cystitis, a condition causing bleeding in the urinary bladder. This condition can occur in patients undergoing chemotherapy with medicines like ifosfamide or cyclophosphamide. Mesna belongs to the class of medicines known as cytoprotective agents.
It is also useful for patients receiving high-dose cyclophosphamide before a bone marrow transplant.
Side effects of Mesna
Nausea and vomiting
Diarrhoea
Abdominal pain
Headache
Fatigue
How Mesna works
Mesna is a protective agent used in chemotherapy. It works by neutralising a harmful substance called acrolein, produced when ifosfamide or cyclophosphamide is broken down in the body. Acrolein can cause severe irritation and damage to the bladder, resulting in a painful condition called hemorrhagic cystitis.
Certified content
Written By
Doctor of Medicine
Reviewed By
BMS, FMC, MD Resident
Expert Advice
Dosage Forms Available
It is available for oral administration (tablets), oral solutions and intravenous administration (injection).
Age and Dose Restrictions
Mesna is typically prescribed for adult patients undergoing chemotherapy.
Contraindications
This medicine is contraindicated in patients with a known hypersensitivity to the medication.
Other Medications to Avoid
It may interact with anticoagulants (such as warfarin and heparin), antiplatelet medicines (like aspirin and clopidogrel), and certain types of anticonvulsants (such as phenytoin and carbamazepine).
Overdose and Missed Dose
An overdose may result in symptoms such as nausea, vomiting, and dizziness. If you suspect an overdose, seek immediate medical attention.
If you miss a dose, take it as soon as you remember. But if it is nearly time for your next dose, skip the missed dose and continue your regular schedule.
Management of Side Effects
Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening symptoms, please consult your doctor.
For nausea or vomiting, try taking this medicine with food or milk.
For mild diarrhoea, ensure adequate hydration by drinking plenty of water.
Use in Driving and Operating Machinery
Mesna may cause drowsiness or dizziness in some patients. If you experience these effects, avoid driving or operating heavy machinery until you feel alert.
Use in Pregnancy and Lactation
This medicine should be used during pregnancy only if needed and the benefits outweigh the risks. Breastfeeding while using Mesna is not recommended. Always consult your doctor before using this medicine during pregnancy or while breastfeeding.
Caution in Other Conditions
Patients with kidney disease should exercise caution when taking Mesna, as it is primarily eliminated through the kidneys.
The dosage of Mesna may need to be adjusted in patients with severe renal dysfunction.
Special Dietary and Lifestyle Recommendations
Ensure sufficient hydration by drinking plenty of water to maintain adequate urine output and minimise the risk of bladder toxicity.
Adequate rest is important to manage side effects like fatigue and dizziness.
Frequently asked questions
Is Mesna a steroid?
No, it is not a steroid. It is a medication used to prevent bleeding in the bladder and urinary tract in patients receiving certain chemotherapy treatments.
Does Mesna have any effect on sleep?
Mesna is not commonly associated with effects on sleep. It is primarily used as a protective agent to reduce the risk of hemorrhagic cystitis caused by certain chemotherapy medicines and does not typically impact sleep patterns.
Will Mesna affect fertility?
This medicine is not commonly associated with effects on fertility. It is used to protect the bladder from irritation caused by chemotherapy medicines and does not typically impact reproductive health.
Is it safe to take Mesna daily?
Mesna should only be taken as prescribed by your doctor. It's often administered in conjunction with specific chemotherapy regimens.
How much time does Mesna take to work?
The time Mesna takes to work can vary depending on several factors, including the type and dose of chemotherapy being administered.
What is the best time to take Mesna?
The best time to take Mesna is as recommended by your doctor. It is typically administered intravenously or orally before, during, and after chemotherapy treatments, depending on the chemotherapy regimen and dosage.
What is the duration of treatment with Mesna?
The duration of treatment with Mesna largely depends on the chemotherapy protocol being followed. Always adhere to your doctor's instructions regarding the duration of treatment.
Mesna in other salts
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