Ifosfamide + Mesna is used mainly for the management of various types of cancer including testicular, ovarian, certain lymphomas, soft tissue sarcomas, selected lung cancers and cervical cancer. This combination belongs to the group of chemotherapy medications.
In addition to managing these cancers, Mesna in combination is used to help reduce the risk of a specific adverse effect known as hemorrhagic cystitis which is associated with Ifosfamide usage.
Nausea and vomiting
Diarrhoea
Loss of appetite
Fatigue
Hair loss
Ifosfamide + Mesna is the combination of alkylating agent chemoprotective agent
Ifosfamide is an alkylating agent. It works by getting converted into an active form in the body, which then blocks the normal functioning of DNA in cancer cells. This hinders cell division and leads to cell death.
Mesna serves as a chemoprotective agent. It binds to acrolein, a harmful compound produced when Ifosfamide is broken down in the body. This binding action neutralises acrolein, preventing it from causing damage to the bladder lining. Thus, while Ifosfamide acts against cancer cells, Mesna protects against one of Ifosfamide's major side effects, thereby enhancing treatment safety and tolerability.
Doctor of Medicine
BAMS, APG, PG
Ifosfamide + Mesna is available for intravenous administration either as a solution for infusion or as a powder for reconstitution.
The combination of Ifosfamide + Mesna is generally recommended for adult patients and children above 12 years of age.
This medicine is contraindicated in patients with known allergies to Ifosfamide or Mesna. It should not be used in individuals with urinary outflow obstruction or severe bone marrow suppression.
Ifosfamide + Mesna may interact with anticoagulants (such as warfarin), muscle relaxants (like suxamethonium), barbiturates (including phenobarbital), sedatives (like chloral hydrate), antiepileptic medicines (such as phenytoin) and certain antibiotics (like rifampin).
An overdose of Ifosfamide + Mesna may lead to symptoms like confusion, drowsiness, hallucinations, or kidney or liver dysfunction. If you observe these symptoms, inform your doctor immediately.
If you miss a dose of Ifosfamide + Mesna injection, contact your doctor right away for further guidance.
Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.
Drinking plenty of fluids may help to manage nausea and prevent dehydration.
Rest and avoiding strenuous activity may help manage fatigue.
Ifosfamide + Mesna is known to potentially cause drowsiness, confusion, or hallucinations. Therefore, it is advised to avoid driving or operating heavy machinery until you know how this medication affects you.
Ifosfamide + Mesna can harm the unborn baby when administered to pregnant women. It is not recommended for use during breastfeeding. Always consult your doctor before using this medicine in pregnancy and breastfeeding.
Patients with liver or kidney impairment should exercise caution while using Ifosfamide + Mesna due to the potential increased risk of toxicity.
It should also be used with caution in patients with existing infections due to the potential for reduced immune function.
Report any blood in the urine or changes in urination to your doctor.
Regular rest periods can help manage fatigue and other side effects related to general well-being.
Limit caffeine intake as it can contribute to dehydration and irritate the bladder, especially when used in large amounts.
Frequently asked questions
Yes, changes in mood and mental status can occur in some patients administering Ifosfamide + Mesna. These can range from mild confusion to severe hallucinations. Consult your doctor if you experience any such changes.
Some supplements may interact with Ifosfamide + Mesna or interfere with its effectiveness. Always tell your doctor about any supplements you are taking before starting treatment with this medication.
Ifosfamide + Mesna can cause menstrual changes. If you notice any changes in your menstrual cycle or have concerns about fertility, consult your doctor.
Yes, Ifosfamide + Mesna can potentially cause temporary or even permanent infertility in both men and women. It's recommended to discuss fertility preservation options with your doctor before starting treatment with this medicine.
Ifosfamide + Mesna is not linked to dependency or withdrawal. However, Ifosfamide can have serious side effects, so it's important to follow your doctor’s instructions carefully.
Regular blood tests will be required to monitor your blood cell counts and kidney function while you are taking Ifosfamide + Mesna. Consult your doctor for more guidance.
The half-life of Ifosfamide + Mesna is variable and depends on several factors, including the specific dose and the individual’s metabolism. Your doctor can provide a more accurate estimate.
Ifosfamide + Mesna in other salts
Subscribe
Claim your complimentary health and fitness tips subscription and stay updated on our newest promotions.
Download Truemeds
Manage your health with ease Download Truemeds today!Get easy access to medicine refills, health information, and more. With our app, you'll never have to wait in line again. Download now and start taking control of your health.
Contact Us
Our customer representative team is available 7 days a week from 9 am - 9 pm.
v3.3.6
Our Payment Partners