L Arginine
Uses of L Arginine
L-arginine is primarily used for its potential health benefits related to its role in protein synthesis and nitric oxide production.
Secondary uses of L-arginine include managing symptoms of angina and peripheral artery disease, enhancing sexual function in individuals with erectile dysfunction, managing high blood pressure, and reducing pregnancy complications such as preeclampsia and gestational hypertension.
Side effects of L Arginine
Digestive issues (bloating, abdominal pain)
Diarrhoea
Low blood pressure
How L Arginine works
L-arginine is an amino acid that plays a crucial role in various bodily functions.
Once consumed, L-arginine converts into a substance known as nitric oxide in the body. Nitric oxide is a powerful vasodilator, that means it helps your blood vessels to relax and widen, enhancing blood circulation throughout your body.
Additionally, L-arginine stimulates the release of insulin, growth hormone, and other substances. It also aids in the production of critical amino acids such as glutamate, proline and creatine, which contribute to maintaining a healthy immune system.
Certified content
Written By
BDS, PGCAD, GMHE (IIM-B)
Reviewed By
Doctor of Medicine
Expert Advice
Dosage Forms Available
L-arginine is naturally present in certain foods and can be consumed as a diet supplement.
L-arginine is a supplement available in various forms, including capsules, tablets, powder, and liquids, intended for oral consumption.
It can also be applied topically on the skin in the form of cream or gel.
Age and Dose Restrictions
Adults of all ages can consume L-arginine.
When it comes to children, it is advisable to consult a doctor before giving them L-arginine supplements, as their bodies produce enough of this amino acid.
Contraindications
L-arginine supplements should be avoided by individuals who have recently experienced a heart attack.
It is also contraindicated for those with kidney disease or rare genetic disorders, such as guanidinoacetate methyltransferase deficiency, that affect arginine metabolism.
Other Medications to Avoid
L-arginine may potentially interact with certain medications like antihypertensive medications (such as beta blockers and ACE inhibitors), nitrates, erectile dysfunction medications (like sildenafil), and diuretics.
It also interacts with anticoagulants (warfarin and heparin) and antiplatelets (aspirin and clopidogrel), which may increase the risk of bleeding and diabetes medications that may cause low blood sugar levels.
You should inform your doctor before starting any prescription or over-the-counter medication while taking L-arginine.
Overdose and Missed Dose
An overdose of L-arginine can lead to digestive issues like bloating, abdominal pain and diarrhoea. If you suspect an overdose, consult your doctor immediately.
If you forget to take a dose of L-arginine, take it as soon as you remember. However, do not double up on doses if it is close to your next scheduled dose.
Management of Side Effects
Most side effects from L-arginine are temporary and resolve after discontinuing the supplement. However, if you experience any severe side effects or worsening of symptoms, consult your doctor immediately.
Drinking plenty of water can help manage some of the digestive side effects like bloating and abdominal discomfort.
Taking the supplement with meals may also help minimise digestive issues.
Use in Driving and Operating Machinery
L-arginine does not generally affect your ability to drive or operate machinery. However, if you feel unwell or experience any side effects that could impair your ability, avoid such activities.
Use in Pregnancy and Lactation
While L-arginine plays a critical role during pregnancy, its supplements are not recommended for pregnant or breastfeeding women unless advised by a doctor. Consult your doctor for proper guidance.
Caution in Other Conditions
Individuals with liver disease should exercise caution when taking L-arginine supplements as it may elevate liver enzymes.
Those with herpes virus (cold sores or genital herpes) should also be cautious, as L-arginine can trigger outbreaks.
Special Dietary and Lifestyle Recommendations
Maintaining a balanced diet rich in proteins such as poultry, meat, fish and dairy products can help ensure adequate levels of L-arginine in the body.
Staying hydrated is always beneficial, particularly if you consume L-arginine supplements, which may cause diarrhoea in some individuals.
Regularly monitoring blood pressure levels is important for individuals taking L-arginine to manage their hypertension, as this supplement can lower blood pressure.
Maintaining a healthy lifestyle with regular physical activity can also be beneficial to support the overall benefits of L-arginine.
Frequently asked questions
What is L-arginine used for?
L-arginine is a semi-essential amino acid that the body uses to make proteins. It is also a precursor for nitric oxide, a molecule that dilates blood vessels and improves blood flow. This makes it potentially useful for managing various health conditions related to blood flow and circulation.
Does L-arginine enhance sexual function?
Yes, research suggests that L-arginine can enhance sexual function, particularly in individuals with erectile dysfunction. Your doctor will prescribe the required dosage to help boost sexual performance, especially when used in conjunction with medications like sildenafil for erectile dysfunction.
Can taking L-arginine help manage high blood pressure?
Yes, L-arginine supplements can help manage high blood pressure in people diagnosed with hypertension. It achieves this by increasing nitric oxide production, which in turn dilates the blood vessels and improves circulation.
Is it safe to consume L-arginine during pregnancy?
While L-arginine plays essential roles in the human body, its safety during pregnancy is unclear. Intravenous administration of L-arginine may reduce blood pressure in conditions like preeclampsia and gestational hypertension. However, users should always consult their doctor before taking any supplement during pregnancy.
Is it possible for L-arginine to interact with other medications?
Yes, L-arginine can interact with several medications, including antihypertensives, nitrates, ED medications, diuretics, anticoagulants, antiplatelets and diabetes medications. Therefore, it is important to inform your doctor about all the medications and supplements you are currently taking before starting on L-arginine.
Does L-arginine have any side effects?
While generally safe and well-tolerated when taken in appropriate doses orally or topically, L-arginine can cause some side effects, such as digestive issues, including bloating, abdominal pain and diarrhoea. It may also cause a drop in blood pressure.
Is L-arginine available as an over-the-counter supplement?
Yes, L-arginine supplements are widely available over the counter in various forms, including capsules, tablets, powders, and liquids. However, it is important to consult a doctor to determine the appropriate dosage and duration of use.
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