Estradiol + Sildenafil
Uses of Estradiol + Sildenafil
Estradiol + Sildenafil is primarily used for the management of erectile dysfunction in men and menopausal symptoms in women, such as vaginal dryness, burning, and irritation. It belongs to the group of sex hormones and phosphodiesterase-5 (PDE5) inhibitors.
Side effects of Estradiol + Sildenafil
Headaches
Flushing of the skin
Nosebleeds
Upset stomach or indigestion
Dizziness
How Estradiol + Sildenafil works
Estradiol is an estrogen, that is, a female sex hormone. When applied to the vaginal tissues, estradiol binds with estrogen receptors present there. This leads to maturation of the vaginal lining and increased lubrication.
Sildenafil is a phosphodiesterase-5 inhibitor. It works by blocking the action of PDE5 enzyme in the body. This enzyme usually breaks down a substance called cGMP which helps to relax blood vessels in the penis.
Together, these two components help to manage erectile dysfunction in men and menopausal symptoms in women effectively.
Certified content
Written By
Doctor of Medicine
Reviewed By
BMS, FMC, MD Resident
Expert Advice
Dosage Forms Available
Estradiol + Sildenafil is available for use via the oral route in the form of tablets.
For women, it is designed to be administered intravaginally.
Age and Dose Restrictions
This medicine is meant for use in adults only aged 18 and older. It is not recommended for children or adolescents.
Contraindications
This medicine is contraindicated in patients with known allergies to estradiol or sildenafil.
It should not be used by patients with severe liver disease, low blood pressure, or penile deformities.
Other Medications to Avoid
This combination may interact with nitrates (such as glyceryl trinitrate), alpha-blockers (like tamsulosin and doxazosin), antifungals (like ketoconazole and itraconazole), antibiotics (like erythromycin and clarithromycin) and medications for pulmonary hypertension (like riociguat).
Overdose and Missed Dose
An overdose of this medication may cause severe side effects like a painful prolonged erection, sudden vision or hearing loss. If you observe these symptoms, inform your doctor immediately.
If you forget to take this medicine, take it as soon as you remember. But avoid repeating the dose if it's almost time for the next dose.
Management of Side Effects
Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.
Headaches can often be managed by staying hydrated.
To manage indigestion or stomach upset, try taking the medication with food.
Use in Driving and Operating Machinery
This medication may cause dizziness. Avoid driving or operating heavy machinery if you feel unsteady after taking this medication.
Use in Pregnancy and Lactation
This medicine is not recommended for use during pregnancy or breastfeeding. Consult your doctor before using Estradiol + Sildenafil in these conditions.
Caution in Other Conditions
Patients with heart problems, stroke, kidney disease, eye disorders, or bleeding problems should exercise caution when taking this medicine.
It should also be used with caution in patients with penile deformities.
Special Dietary and Lifestyle Recommendations
Maintain a balanced diet rich in fruits, vegetables, and whole grains to support overall health.
Regular physical activity can improve cardiovascular health and reduce erectile dysfunction in men.
Frequently asked questions
Is Estradiol + Sildenafil a steroid?
No, Estradiol + Sildenafil is not a steroid. Estradiol is a form of estrogen, which is a naturally occurring female sex hormone. Sildenafil, on the other hand, is a phosphodiesterase-5 (PDE5) inhibitor used for the management of erectile dysfunction in men.
Will Estradiol + Sildenafil affect my mood or emotions?
Neither estradiol nor Sildenafil are known to directly affect mood or emotions. However, menopausal symptoms like hot flashes and vaginal dryness, which can be managed by estradiol, may indirectly affect mood. Likewise, managing erectile dysfunction with sildenafil may impact emotional well-being positively.
Does Estradiol + Sildenafil cause dependency or addiction?
Estradiol + Sildenafil is not known to cause dependency or addiction. This is prescribed for specific medical conditions, and it's important to use this combination as directed by a doctor.
How do I know if I am allergic to Estradiol + Sildenafil?
If you experience difficulty breathing, dizziness, rash, itching or swelling (especially of the face, tongue or throat) after taking Estradiol + Sildenafil, these may be symptoms of an allergic reaction. Seek immediate medical attention.
Is it safe to take Estradiol + Sildenafil daily?
The safety of daily use of Estradiol + Sildenafil is dependent on your health condition and is best determined by your doctor.
What is the best time to take Estradiol + Sildenafil?
The best time to take this medicine can vary depending on individual circumstances and should be determined in consultation with your doctor.
Will Estradiol + Sildenafil affect fertility?
Estradiol can impact fertility by influencing hormonal balance, while Sildenafil does not typically affect fertility. If you have concerns about fertility while taking this medication, consult your healthcare provider.
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