Sacu V 50 Mg Tablet 14

Sacu V 50 Tablet 14

Glenmark Pharmaceuticals Ltd.

Strip of 14 Units

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MRP ~~₹291~~

₹238.62

₹20.79/Units

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Composition

Sacubitril (24 Mg) + Valsartan (26 Mg)

Strength:

24 MG 49 MG

Sacu-V 50 Tablet is primarily used to manage symptomatic chronic heart failure with reduced ejection fraction. This combination medication falls under the category of neprilysin inhibitors and angiotensin II receptor blockers (ARBs).

This tablet manages heart failure and helps reduce the risk of cardiovascular death and hospitalisation. It works in conjunction with other heart failure therapies to improve survival and alleviate clinical symptoms in patients.

Before starting this medication, it's crucial you consult your doctor about your dosage and frequency. Be sure to inform them about any preexisting conditions or ongoing medications. If you notice any side effects while taking this medicine, notify your doctor right away. Continue taking the medicine for the duration prescribed by your doctor for optimal results.

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Sacu-V 50 Tablet is used for the following:

Managing symptomatic chronic heart failure with reduced ejection fraction: This medicine helps manage the symptoms of this type of heart failure, where the heart doesn't pump out as much blood as it should.
Reducing the risk of cardiovascular death: Regular use can decrease the chances of dying from heart-related conditions.
Decreasing hospitalisation due to heart failure: Sacu-V 50 Tablet can help reduce the frequency of hospital stays in heart failure patients.
Used in place of ACE inhibitors or other angiotensin II receptor blockers (ARBs): This medicine can be considered as an alternative to these types of medications in certain cases.

Directions for Use of Sacu V 50 Tablet 14

To properly administer Sacu-V 50 Tablet, follow these steps:

Swallow the tablet whole with a glass of water.
Avoid crushing or chewing the tablet, as it may affect how well it works.
The tablet can be taken with or without food, depending on your preference.
Do not take more than your doctor has prescribed. If you have any doubts about the dosage, consult your doctor for guidance.

Sacu-V 50 Tablet is taken orally.

Sacu-V 50 Tablet may have the following common side effects:

Hypotension: This implies low blood pressure, which might make you feel dizzy or faint.
Hyperkalemia: This refers to high levels of potassium in your blood, which could cause heart palpitations.
Cough
Dizziness: You might feel unsteady, lightheaded or as if you're about to faint.
Renal Failure: This is a medical condition where the kidneys lose the ability to sufficiently filter waste from your blood.

Managing the Side Effects:

Most side effects are temporary and generally harmless, and they resolve when you discontinue using Sacu-V 50 Tablet. However, if you experience any serious side effects or worsening of any of the symptoms, please consult your doctor.

Here are some general guidelines for managing common side effects:

Hypotension: If Sacu-V 50 Tablet is causing low blood pressure, consider taking it in the evening.
Dizziness: If you feel dizzy after taking this medicine, try taking it before bedtime.

Sacu-V 50 Tablet consists of two active ingredients:

Sacubitril (24 mg): This component is a prodrug that is metabolised into LBQ657, an inhibitor of an enzyme called neprilysin. Neprilysin is responsible for breaking down several vasoactive substances, including natriuretic peptides and bradykinin. By inhibiting neprilysin, sacubitril elevates the levels of these peptides, enhancing their beneficial effects on cardiovascular and renal health.
Valsartan (26 mg): As an angiotensin II receptor blocker (ARB), valsartan impedes the actions of angiotensin II on the AT1 receptor. This action reduces vasoconstriction, sodium and water retention, cardiac hypertrophy, and fibrosis.

Together, these ingredients result in vasodilation, decreased sodium and water retention, reduced cardiac workload, and inhibited cardiac remodelling. These combined effects contribute to improved cardiac function and reduced hospitalisation and mortality rates among heart failure patients.

Pregnancy

Sacu-V 50 Tablet should be discontinued as soon as pregnancy is detected, particularly during the 2nd and 3rd trimesters, which may cause harm to the developing foetus. It's best to consult your doctor before taking this medicine if you are pregnant or planning to conceive.

Breastfeeding

No specific information is available about the use of Sacu-V 50 Tablet during breastfeeding. Hence, caution is advised while taking this medicine if you are nursing. Always consult your doctor before taking this medication.

Alcohol

The interaction of Sacu-V 50 Tablet with alcohol is unknown. It's best to discuss with your doctor about consumption of alcohol while taking this medicine.

Liver

Sacu-V 50 Tablet can be taken by patients with mild to moderate liver impairment. However, caution is advised if you have severe liver problems. Consult your doctor before starting this medicine.

Kidney

If you have a history of kidney problems, consult your doctor before taking Sacu-V 50 Tablet. Your kidney function may need close monitoring while using this medicine.

Using Machines & Driving

The effect of Sacu-V 50 Tablet on your ability to drive or operate machinery is not known. If you feel dizzy or unwell after taking this medicine, avoid driving or operating heavy machinery until you feel better.

Allergy

Do not take Sacu-V 50 Tablet if you have a history of angioedema or are allergic to sacubitril, valsartan, or any other ingredients. Before starting this medicine, let your doctor know about any allergies.

Children

Sacu-V 50 Tablet is meant for adults and is not recommended for children under 18 years of age. Always consult with your doctor before giving any medication to a child.

Older Patients

Older patients may be more susceptible to the side effects of Sacu-V 50 Tablet. If you are above 70 years of age, take this medicine under medical supervision. Your doctor will guide you based on your overall health status.

Drug-Drug Interactions

ACE inhibitors and ARBs: Combining Sacu-V 50 Tablet with ACE inhibitors (like enalapril or lisinopril) or another ARB (like losartan) could amplify the risk of hypotension, hyperkalaemia, and renal impairment.
Direct Renin Inhibitors: If you're using aliskiren, a direct renin inhibitor, it could interact with Sacu-V 50 Tablet, causing similar effects as above.
NSAIDs: Nonsteroidal anti-inflammatory drugs such as ibuprofen can reduce blood pressure, lowering the effect of Sacu-V 50 tablets and potentially worsening renal function.
Potassium Supplements and Potassium-Sparing Diuretics: These can significantly increase serum potassium when used in conjunction with Sacu-V 50 Tablet.
Lithium: This medicine's levels can rise if taken alongside Sacu-V 50 Tablet, potentially leading to lithium toxicity.

Drug-Food Interactions

No specific food items are known to interact significantly with Sacu-V 50 Tablet. However, maintaining a balanced diet is always beneficial for overall health.

Drug-Disease Interactions

Sacu-V 50 Tablet interacts with the following diseases:

Renal Impairment: If you have kidney problems, this medicine may worsen your condition. Regular monitoring of kidney function is advised during its use.
Liver Disease: Patients suffering from liver disease should be cautious while using Sacu-V 50 Tablet as its metabolism could be affected.
Diabetes: Since this medicine may increase potassium levels, it could impact blood sugar control in diabetic patients. Regular monitoring of blood sugar levels is recommended.

Daily Dose

Remember, the daily dose of Sacu-V 50 Tablet should be taken as directed by your doctor. The dosage might vary depending on factors like the severity of your condition and your response to treatment. Always stick to the prescribed dosage and don't exceed it without discussing it with your doctor.

Over Dose

If you accidentally take more Sacu-V 50 Tablets than recommended, you might experience symptoms like dizziness or lightheadedness. In such cases, it would be wise to inform your doctor about your situation.

Missed Dose

If you miss a dose, take it as soon as you remember. But if it's nearly time for your next dose, leave out the missed one and continue with your usual schedule. Don't double up on doses without consulting with your doctor.

Store Sacu-V 50 Tablet in a cool and dry place, ideally at a temperature not exceeding 30°C.
Keep the product protected from light and moisture to maintain its effectiveness.
Always ensure Sacu-V 50 Tablet is kept out of reach of children.
Use the medicine before its expiry date for optimal results.

As Sacu-V 50 Tablet is used to manage heart failure, ensure you follow a low-sodium diet. Excessive salt can lead to fluid retention and worsening heart conditions.
Engage in regular mild to moderate physical activity as recommended by your doctor. It helps strengthen your heart muscles, contributing to better heart health.

Fact Box

Drug Category	Neprilysin Inhibitor, Angiotensin II Receptor Blocker
Therapeutic Category	Heart Failure Management
Available Dosage Types	Tablet
Habit Forming	No
Ailment	Chronic Heart Failure, Cardiovascular Risk Reduction

What is Sacu-V 50 Tablet used for?

Sacu-V 50 Tablet is used to manage chronic heart failure, reducing the risk of cardiovascular death and frequent hospitalisations.

How does Sacu-V 50 Tablet work?

Sacu-V 50 Tablet contains sacubitril and valsartan, which work together to improve heart function by enhancing beneficial peptides and blocking the detrimental effects of certain hormones.

Can Sacu-V 50 Tablet be taken with food?

Yes, Sacu-V 50 Tablet can be taken with or without food. It should be swallowed whole with water and not crushed or chewed.

Who should avoid using Sacu-V 50 Tablet?

Pregnant women should avoid using Sacu-V 50 Tablet as it can cause harm to the developing baby, especially during the second and third trimesters.

What are the common side effects of Sacu-V 50 Tablet?

The most common side effects include low blood pressure, high blood potassium levels, cough, dizziness, and kidney problems.

Can Sacu-V 50 Tablet interact with other medicines?

Yes, it can interact with ACE inhibitors, ARBs, renin inhibitors, potassium-sparing diuretics, NSAIDs, and lithium. Always consult your doctor before starting any new medication.

How should I store Sacu-V 50 Tablet?

Store this medicine at room temperature (25°C), away from light and moisture, and out of the reach of children.

Certified Content

Written by

Dr Vatsalya D Ghanekar

Medical Content Writer | 5 years

MD Ayurveda

Reviewed by

Dr. Meenakshi Maruwada

Medical Content Writer & Strategist | 7 years

BDS, PGCAD, GMHE (IIM-B)

Check out Editorial Policy

References

U.S. Food and Drug Administration. (2015). FDA Drug Safety Communication: FDA warns about new impulse control problems associated with mental health drug aripiprazole (Abilify, Abilify Maintena, Aristada). Retrieved from https://www.fda.gov/media/134841/download on 1 April 2024.
Nicolas D, Kerndt CC, Patel P, et al. (2022, May 26). Sacubitril-valsartan - StatPearls - NCBI bookshelf. National Center for Biotechnology Information. https://www.ncbi.nlm.nih.gov/books/NBK507904/

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