E Cef S 500250 Mg Injection 10 Ml

E-cef S 500/250 MG Injection 1

Lupin Ltd

Vial of 1 UNITS

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MRP ~~₹72~~

₹59.04

₹72.00/UNITS

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Prescription required for this medicine

Store in refrigerator or (2^o - 8^o C) Do Not Freeze

Composition

Ceftriaxone (500 Mg) + Sulbactam (250 Mg)

E-cef S 500/250 MG Injection 1 is primarily used for managing a wide range of bacterial infections. This medicine is a combination formulation that belongs to the group of antibiotics known as cephalosporins.

It helps manage lower respiratory tract infections like pneumonia, skin and structure infections, urinary tract infections, bacterial septicemia, bone and joint infections, intra-abdominal infections, and meningitis.

Your doctor needs to know about any pre-existing conditions or ongoing medications you have before you start using this medicine. If you notice any side effects while on this medicine, make sure to inform your doctor immediately. It's crucial that you continue using the injection for the duration prescribed by your doctor for optimal results.

E-cef S 500/250 MG Injection 1 is used for managing the following conditions:

Lower respiratory tract infections such as pneumonia
Skin and skin structure infections
Urinary tract infections (UTIs)
Bacterial septicemia, a severe infection that spreads through the bloodstream
Bone and joint infections
Infections within the abdomen
Meningitis, an infection of the membranes covering the brain and spinal cord

Directions for Use of E-cef S 500/250 MG Injection 1

A healthcare professional should administer this injection.
It can be administered intravenously (into a vein) or intramuscularly (into a muscle).

E-cef S 500/250 MG Injection 1 is administered via intravenous or intramuscular injection.

Side Effects of E-cef S 500/250 MG Injection 1

E-cef S 500/250 MG Injection 1 may have the following common side effects:

Local reactions at the injection site, such as pain and tenderness
Diarrhoea
Nausea and vomiting
Itchiness

Managing the Side Effects:

Most side effects are temporary and generally harmless, which resolve on discontinuing the use of E-cef S 500/250 MG Injection 1. However, if you experience any serious side effects or worsening of any of the symptoms, please consult your doctor.

Here are some general guidelines for managing common side effects:

Local reactions at the injection site: Pain and tenderness at the injection site can be managed by applying a cold compress to the area.
Nausea and vomiting: To lessen this effect, try administering E-cef S 500/250 MG Injection 1 after meals.

How E-cef S 500/250 MG Injection 1 Works?

E-cef S 500/250 MG Injection 1 comprises two active ingredients:

Ceftriaxone (500 mg): This antibiotic works on gram-positive and gram-negative bacteria by blocking their cell wall formation. It binds to and turns off the enzymes called penicillin-binding proteins that are crucial for creating the peptidoglycan layer of the bacterial cell wall. By disrupting this process, ceftriaxone causes the bacterial cells to break down and die.
Sulbactam (250 mg): While sulbactam has minimal antibacterial activity, it boosts ceftriaxone's effectiveness against bacteria that produce beta-lactamase enzymes. Certain bacteria produce these enzymes to neutralise beta-lactam antibiotics. Sulbactam inhibits these enzymes, protecting ceftriaxone from being broken down and thereby enhancing its antibacterial action against these specific strains of bacteria.

Pregnancy

If you are pregnant, caution is advised while administering E-cef S 500/250 MG Injection 1. It is best to consult your doctor before using this medicine.

Breastfeeding

Caution is advised when administering E-cef S 500/250 MG Injection 1 if you are breastfeeding. It is always best to speak with your doctor in this case.

Alcohol

Caution is advised when consuming alcohol if this injection is prescribed to you to avoid any adverse effects.

Liver

If you have a history of liver health issues, caution is advised while using E-cef S 500/250 MG Injection 1. Your doctor will guide you based on your health status.

Kidney

For individuals with kidney health concerns, caution is advised when using E-cef S 500/250 MG Injection 1. Please consult your doctor for guidance.

Using Machines & Driving

E-cef S 500/250 MG Injection 1 does not usually affect your ability to drive or operate machinery. However, if you experience any side effects that may impair these abilities, avoid driving or operating machinery and consult your doctor.

Allergy

E-cef S 500/250 MG Injection 1 should not be used if you are allergic to ceftriaxone, sulbactam or any other components of the formulation. If you have a history of severe allergic reactions to cephalosporins or penicillins, it's best to discuss this with your doctor before starting this medicine.

Children

E-cef S 500/250 MG Injection 1 is not indicated for use in children under 18 years of age. Always consult your doctor before giving any medicine to a child.

Older Patients

Older patients should use E-cef S 500/250 MG Injection 1 under medical supervision as they may be more susceptible to its side effects. Caution is advised if patients are above 70 years of age. Your doctor will guide you based on your health status.

Interactions of E-cef S 500/250 MG Injection 1

Drug-Drug Interactions

E-cef S 500/250 MG Injection 1 interacts with the following medicines:

Calcium-containing solutions or products: Calcium supplements like calcium carbonate or calcium citrate when used with E-cef S 500/250 MG Injection 1, can cause precipitation. This means that a solid forms in the liquid medicine, which can affect how well it works.
Uricosuric agents: Medicine like probenecid can increase the levels of ceftriaxone and sulbactam (the active ingredients in E-cef S 500/250 MG Injection 1) in your blood. This slows down how quickly your body gets rid of these medicines, which could lead to increased side effects.
Oral anticoagulants: Medicines like warfarin help prevent blood clots. Ceftriaxone, one of the active ingredients in E-cef S 500/250 MG Injection 1, can make these medicines work more effectively, which may increase your risk of bleeding.

Drug-Food Interactions

None

Drug-Disease Interactions

E-cef S 500/250 MG Injection 1 interacts with the following diseases:

Allergies: If you have had severe allergic reactions to cephalosporins or penicillins, you should not use E-cef S 500/250 MG Injection 1. It contains ceftriaxone, a type of cephalosporin, which could cause a similar reaction.
Gastrointestinal diseases: If you have a history of diseases affecting your stomach or intestines, especially colitis (inflammation of the colon), you should use E-cef S 500/250 MG Injection 1 with caution. It may cause diarrhoea associated with Clostridium difficile bacteria.
Renal impairment: If you have kidney disease or poor kidney function, your doctor may need to adjust your dose of E-cef S 500/250 MG Injection 1.

Daily Dose

Your doctor will prescribe the recommended dosage of E-cef S 500/250 MG Injection 1 based on individual factors such as your health condition and how you respond to the medicine.

Over Dose

Overdose of this injection is unlikely as a healthcare professional administers it. If you suspect an overdose and experience symptoms such as severe diarrhoea or vomiting or any other severe side effects, consult your doctor for guidance.

Missed Dose

In case you miss a dose of E-cef S 500/250 MG Injection 1, administer it as soon as you remember. However, if it's nearing the time for your next dose, skip the missed one and continue with your regular schedule.

Store E-cef S 500/250 MG Injection 1 in refrigerator or (2°C - 8°C).
Avoid exposure to direct sunlight and excessive moisture.
Don't freeze the medicine.
Always store the medicine out of reach of children.

Drink plenty of fluids to help flush bacteria from your urinary system.
Maintain good hygiene practices, such as washing your hands regularly and keeping wounds clean to prevent further bacterial growth.

Fact Box

Drug Category	Cell Wall Synthesis Inhibitor, Beta-lactamase Inhibitor
Therapeutic Category	Antibiotic
Available Dosage Types	Injection
Habit Forming	No
Ailment	Pneumonia, Skin Infections, Urinary Tract Infections

What is E-cef S 500/250 MG Injection 1 used for?

E-cef S 500/250 MG Injection 1 is used to manage a variety of bacterial infections such as pneumonia, skin infections, urinary tract infections, septicemia, bone infections, and meningitis.

How does E-cef S 500/250 MG Injection 1 work?

This injection contains ceftriaxone and sulbactam. Ceftriaxone kills bacteria by disrupting their cell walls, while sulbactam protects ceftriaxone from being deactivated by certain bacteria.

Can I use E-cef S 500/250 MG Injection 1 if I am allergic to penicillin?

No, if you have a history of severe allergic reactions to cephalosporins or penicillins, you should not use E-cef S 500/250 MG Injection 1. Consult your doctor for alternatives.

What are the side effects of E-cef S 500/250 MG Injection 1?

Common side effects include pain at the injection site, diarrhoea, nausea, vomiting, rash, and itchiness. Consult your doctor if they persist or worsen.

Can I use E-cef S 500/250 MG Injection 1 during pregnancy or while breastfeeding?

Ceftriaxone and sulbactam can cross the placenta and are excreted in milk. Use during pregnancy or while breastfeeding should be only if clearly needed.

Can I drink alcohol while using E-cef S 500/250 MG Injection 1?

Alcohol consumption while using this medicine is not recommended. Always discuss your lifestyle habits with your doctor before starting any new medication.

How should I store E-cef S 500/250 MG Injection 1?

Store E-cef S 500/250 MG Injection 1 in refrigerator or (2°C - 8°C)., protected from light and out of reach of children. Do not freeze. Reconstituted solutions should be used within 24 hours.

Certified Content

Written by

Dr Nikita Lobo

Medical Editor & Reviewer | 7 years

BDS, MDS

Reviewed by

Dr. Divya Chauhan

Medical Writer & Reviewer | 6 years

BAMS, APG, PG

Check out Editorial Policy

References

Ceftriaxone: Uses, interactions, mechanism of action | DrugBank Online. (n.d.). DrugBank. https://go.drugbank.com/drugs/DB01212
Ceftriaxone injection: MedlinePlus drug information. (n.d.). https://medlineplus.gov/druginfo/meds/a685032.html
National Center for Biotechnology Information (2024). PubChem Compound Summary for CID 5479530, Ceftriaxone. Retrieved June 17, 2024 from https://pubchem.ncbi.nlm.nih.gov/compound/Ceftriaxone
Sulbactam: Uses, interactions, mechanism of action | DrugBank Online. (n.d.). DrugBank. https://go.drugbank.com/drugs/DB09324
National Center for Biotechnology Information (2024). PubChem Compound Summary for CID 130313, Sulbactam. Retrieved June 17, 2024 from https://pubchem.ncbi.nlm.nih.gov/compound/Sulbactam

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