Vericiguat
Uses of Vericiguat
The primary use of this medicine is to reduce the risk of cardiovascular mortality and hospitalization related to heart failure in adult patients with reduced left ventricular ejection fraction and chronic heart failure symptoms. It belongs to the group of soluble guanylate cyclase (sGC) stimulators.
In addition, it is also used in patients who have recently been hospitalized due to heart failure or require outpatient intravenous diuretics.
Side effects of Vericiguat
Hypotension or low blood pressure
Anaemia
Headaches
Dizziness
Gastrointestinal disturbances
How Vericiguat works
Vericiguat is a stimulator of soluble guanylate cyclase (sGC), an enzyme.
It works by specifically binding to a site on the sGC enzyme, stimulating it independently of nitric oxide (NO). This action leads to an increase in the production of cyclic guanosine monophosphate (cGMP), a substance that helps relax the muscles lining blood vessels.
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Expert Advice
Dosage Forms Available
Vericiguat is available for oral administration in the form of tablets.
Age and Dose Restrictions
It is intended for use in adults of age above 18 years, particularly those with symptomatic chronic heart failure.
Contraindications
This medicine is contraindicated in patients with known hypersensitivity to Vericiguat.
It is contraindicated for patients with severe liver impairment.
It is also contraindicated for concomitant use with other soluble guanylate cyclase (sGC) stimulators.
Other Medications to Avoid
This medicine can interact with phosphodiesterase type 5 inhibitors (such as sildenafil and tadalafil) and antihypertensive medications (like amlodipine and losartan).
Overdose and Missed Dose
An overdose may lead to excessive hypotension and anaemia. If you experience symptoms of overdosage, consult your doctor immediately.
If you miss a dose, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular schedule.
Management of Side Effects
Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any symptoms, please consult your doctor.
Drinking plenty of water can help manage common side effects like headaches.
Lying down or sitting with your legs elevated can help manage hypotension.
Use in Driving and Operating Machinery
Vericiguat has been reported to cause dizziness and fatigue. Therefore, caution should be exercised while driving or operating heavy machinery until you know how this medicine affects you.
Use in Pregnancy and Lactation
This medicine is contraindicated in pregnant women due to the potential risk of fetal harm.
It is advised to consult a doctor if you are breastfeeding.
Caution in Other Conditions
Patients with low blood pressure, anaemia, or severe renal impairment should exercise caution when taking Vericiguat.
Special Dietary and Lifestyle Recommendations
Following a heart-healthy diet that includes plenty of fruits, vegetables, whole grains, lean proteins, and healthy fats can help manage heart failure.
Limiting salt intake can help prevent fluid accumulation and swelling.
Regular monitoring of weight can help detect fluid retention early. A sudden weight gain should be reported to a doctor.
Stress management techniques, such as meditation or yoga, can help improve heart health.
Frequently asked questions
Does Vericiguat affect my mood?
This medicine is not associated with having a direct impact on mood. However, as it is used to manage heart conditions, overall improvement in physical health might indirectly influence mood. Consult your doctor if you have any concerns about mood changes.
Is Vericiguat a habit-forming medicine?
No, Vericiguat does not lead to dependency or addiction. It is a medication for heart conditions and should be taken strictly as prescribed by your doctor.
Does Vericiguat have any impact on menstruation?
Vericiguat is not known to affect menstruation. However, if you notice any changes in your menstrual cycle while taking this medication, consult your doctor.
How long does the effect of Vericiguat last in the body?
The effect of vericiguat is prolonged due to its long half-life, which is approximately 30 hours. This allows for once-daily dosing, providing consistent therapeutic effects.
Can Vericiguat be used by vegetarians and vegans?
Yes, it is suitable for both vegetarians and vegans. However, it is always recommended to check the medicine packaging for all ingredients to ensure they adhere to your dietary standards.
Is there any natural alternative to Vericiguat?
There is no direct natural alternative to Vericiguat as it is a specifically formulated medication for heart failure. Always consult your doctor before trying any alternative remedies.
Should I monitor any specific health parameters while on Vericiguat?
While on Vericiguat, your doctor may monitor your blood pressure and check for signs of anaemia regularly.
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