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Ulinastatin

Uses of Ulinastatin

  • The primary use of Ulinastatin is to manage acute pancreatitis and severe sepsis. It belongs to the group of protease inhibitor medications.

  • Additionally, it is also used in the management of shock and several other inflammatory conditions, such as arthritis and ulcerative colitis.

Side effects of Ulinastatin

  • Pain, redness, and swelling on injection site

  • Gastrointestinal symptoms like nausea, vomiting, diarrhoea

  • Headache

  • Rash or itching

How Ulinastatin works

  • Ulinastatin is a serine protease inhibitor. It works by binding to and deactivating certain enzymes, such as trypsin, chymotrypsin, neutrophil elastase, and plasmin. These enzymes are involved in triggering inflammation in the body. By inhibiting these enzymes, Ulinastatin helps to reduce inflammation and prevent damage to the tissues. It also lowers the production of pro-inflammatory cytokines and chemokines that contribute to inflammation.

Certified content

Written By

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Dr. Osama AhmedDental/Medical Writer, Editor, Reviewer|

Bachelor of Dental Surgery

Reviewed By

Dr. Michelle Frank
Dr. Michelle FrankMedical Content Writer| 8 Years

Doctor of Medicine

Expert Advice

Dosage Forms Available

  • Ulinastatin is typically administered through an intravenous (IV) route.

  • It is available as a sterile, lyophilized powder that is reconstituted with saline or dextrose solution before administration through the intravenous route.

Age and Dose Restrictions

  • This medication is typically prescribed for adults of age above 18 years.

Contraindications

  • Ulinastatin is contraindicated in individuals with a history of hypersensitivity reactions to this medicine.

Other Medications to Avoid

  • Ulinastatin may interact with anticoagulants (such as heparin and warfarin) and immunosuppressants (such as corticosteroids and cyclosporine).

Overdose and Missed Dose

  • Overdose of Ulinastatin may lead to symptoms like nausea, vomiting, and diarrhoea. If you observe these symptoms, inform your doctor immediately.

  • If you miss an appointment for a Ulinastatin injection, contact your healthcare provider as soon as possible to reschedule.

Management of Side Effects

Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.

  • If you experience nausea or vomiting after receiving Ulinastatin, try taking it with meals.

  • If you experience itching or rashes, using a cold compress can provide relief.

Use in Driving and Operating Machinery

  • Ulinastatin does not typically influence your ability to drive or operate machinery. However, if you experience dizziness or other side effects that could impair your concentration, avoid these activities until the effects wear off.

Use in Pregnancy and Lactation

  • It is advised to consult your doctor before using this medication during pregnancy or while breastfeeding.

Caution in Other Conditions

  • Patients with kidney or liver impairment should exercise caution when taking Ulinastatin as dose adjustments may be necessary in these patients.

Special Dietary and Lifestyle Recommendations

  • For managing conditions like pancreatitis or sepsis for which Ulinastatin is prescribed, a low-fat diet high in protein can help support recovery.

  • Fluid intake should be maintained to prevent dehydration.

Frequently asked questions

No, Ulinastatin does not contain steroids. It belongs to a class of medications known as protease inhibitors, which help control inflammation and tissue damage in the body.

There is no known impact of Ulinastatin on sleep patterns. However, individual reactions to medicines can vary. If you notice any changes in your sleep after starting this medication, consult your doctor.

The effect of Ulinastatin on fertility has not been extensively studied. If you are planning to conceive or have fertility concerns, it is advised to consult with your doctor before starting this medication.

For daily use, it is crucial to follow a healthcare provider's guidance, as they assess the risks versus benefits in each case based on the patient's specific condition. You should only administer it as prescribed by the doctor.

Ulinastatin starts showing effects within hours to days of starting treatment. However, the full benefits may take several days to become apparent, depending on the condition being treated.

Yes, Ulinastatin is not sold over the counter and requires a prescription from a registered medical practitioner.

No, Ulinastatin does not cause dependency or addiction as it does not have any psychoactive properties.

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