Trastuzumab
Uses of Trastuzumab
The primary use of Trastuzumab is to manage certain types of breast and stomach cancer. It falls under the category of monoclonal antibody medications.
Trastuzumab is specifically indicated for HER2-positive breast cancer, both early-stage and metastatic, as well as HER2-positive metastatic stomach cancer or gastroesophageal junction adenocarcinoma.
Side effects of Trastuzumab
Fever
Chills
Headache
Nausea
Weakness
How Trastuzumab works
Trastuzumab is a monoclonal antibody.
It targets and binds to the HER2 protein on certain cancer cells. By attaching to HER2, it blocks growth signals, slows cancer cell proliferation, and marks them for immune system destruction through antibody-dependent cell-mediated cytotoxicity (ADCC). Additionally, Trastuzumab prevents the shedding of the HER2 protein and stops the growth of new blood vessels in tumours, further hindering the expansion of cancer.
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Written By
Doctor of Medicine
Reviewed By
BMS, FMC, MD Resident
Expert Advice
Dosage Forms Available
Trastuzumab is administered either through intravenous (IV) infusion or subcutaneous (under the skin) route.
Age and Dose Restrictions
Trastuzumab is intended for use in adults.
Contraindications
Trastuzumab should not be used in individuals with a known allergy to trastuzumab or any component of the formulation. It is also contraindicated in individuals with severe heart failure or uncontrolled high blood pressure.
Other Medications to Avoid
Trastuzumab can interact with anthracycline chemotherapy medicines (e.g., doxorubicin, epirubicin) and other chemotherapy agents (e.g., paclitaxel).
Overdose and Missed Dose
In case of an overdose of Trastuzumab, immediate medical attention should be sought. Symptoms may vary depending on the extent of overdose and individual patient characteristics.
If you miss a dose, consult with your doctor. Do not double up on your dose.
Management of Side Effects
Most side effects of Trastuzumab are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.
Drinking plenty of water may help manage mild nausea or vomiting.
Rest and adequate sleep may alleviate feelings of weakness or fatigue.
Use in Driving and Operating Machinery
Trastuzumab may cause some side effects such as fatigue which could affect the ability to drive or operate machinery. Individuals should be cautious and avoid such activities if they experience these side effects.
Use in Pregnancy and Lactation
Trastuzumab is not recommended for use during pregnancy due to the risk of fetal harm.
Caution in Other Conditions
Individuals with heart conditions should use Trastuzumab with caution, as it may affect heart function. Regular monitoring of heart function is advised during treatment. Caution should also be exercised in individuals with lung conditions, as Trastuzumab may cause serious lung damage in rare cases.
Special Dietary and Lifestyle Recommendations
Drink plenty of fluids, such as water and herbal teas to help with treatment-related side effects like dehydration and fatigue.
Eat small, frequent meals and choose bland or easy-to-digest foods to overcome nausea and gastrointestinal discomfort.
Keep up with scheduled appointments and follow your doctor's advice regarding monitoring and adjustments to your treatment plan.
Frequently asked questions
Does Trastuzumab have any impact on mood or mental health?
Trastuzumab is not known to directly affect mood or mental health. However, the experience of having cancer and its treatment can lead to mental health challenges like stress, anxiety, and depression.
Are there any natural alternatives to Trastuzumab?
No natural alternatives to Trastuzumab have been identified. It is a targeted therapy designed to interfere with specific proteins in cancer cells, which is not something that can be achieved with natural substances.
Can Trastuzumab cause weight gain or weight loss?
Weight changes are not commonly reported side effects of Trastuzumab. However, other factors associated with cancer and its treatment can affect your weight.
Does Trastuzumab have any effect on menstruation?
Trastuzumab is not known to have any direct effects on menstrual cycles. However, other chemotherapy medicines may affect menstruation. Consult your doctor, if you have any menstrual issues.
Is Trastuzumab a vegetarian medication?
Trastuzumab is a protein-based medication produced using biotechnology methods. It does not contain any animal-derived ingredients and can be considered suitable for vegetarians.
How long do I need to be on Trastuzumab treatment?
The duration of treatment with Trastuzumab can vary depending on individual needs and response to the medication. Always follow your doctor's instructions regarding the duration of treatment.
Can I buy Trastuzumab over the counter or do I need a prescription?
Trastuzumab is a prescription-only medication. It is not available over the counter.
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