Tocotrienols
Uses of Tocotrienols
Tocotrienols are primarily used for their antioxidant and anti-inflammatory effects, and they belong to the vitamin E family of compounds.
Secondary uses include supporting heart health by potentially lowering cholesterol levels, helping manage diabetes and improving blood sugar control, offering potential protection against certain cancers, promoting brain health, and enhancing skin and hair health.
Side effects of Tocotrienols
Fatigue
Headaches
Dizziness
Rashes
Gastrointestinal symptoms
How Tocotrienols works
Tocotrienols belong to the Vitamin E family and are essentially antioxidants.
They exert their effects primarily through antioxidant activity, protecting cells from oxidative damage by neutralizing free radicals. They also inhibit the enzyme HMG-CoA reductase, which is involved in cholesterol synthesis, potentially lowering cholesterol levels. Additionally, Tocotrienols have anti-inflammatory properties and may induce apoptosis in cancer cells, contributing to their potential protective effects against various diseases.
Certified content
Written By
Doctor of Medicine
Reviewed By
BMS, FMC, MD Resident
Expert Advice
Dosage Forms Available
Tocotrienols are available in the form of dietary supplements which can be taken orally. They can also be found in skincare products such as creams and lotions which can be applied topically to the skin.
Age and Dose Restrictions
Tocotrienols are generally safe for adults when used as directed. However, it's still advisable to consult a doctor before applying them to children.
Contraindications
Tocotrienols should not be used by individuals allergic to any component of the supplement.
Patients with a history of bleeding disorders or those who are about to undergo surgery should avoid Tocotrienols since they may slow blood clotting.
Other Medications to Avoid
Tocotrienols can interact with certain medication classes. For example, they may increase the risk of bleeding when taken with anticoagulants (e.g., warfarin) and antiplatelet medicines (e.g., aspirin). Additionally, Tocotrienols can potentially interfere with the effectiveness of statins (e.g., atorvastatin, simvastatin) and other cholesterol-lowering medications. It’s important to consult a doctor before combining Tocotrienols with these or other medications to ensure safe use.
Overdose and Missed Dose
Overdosing on Tocotrienols could potentially cause side effects like fatigue, headaches, dizziness, rashes, or gastrointestinal symptoms. If you suspect an overdose, consult a doctor immediately.
If you miss a dose of your Tocotrienols supplement, take it as soon as you remember. However, if it is close to the time for your next dose, skip the missed dose and go back to your regular schedule.
Management of Side Effects
Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.
Drinking plenty of water may help manage any gastrointestinal side effects like stomach upset.
Resting or taking a nap may help manage fatigue.
Use in Driving and Operating Machinery
Tocotrienols may cause dizziness or fatigue in some people. If you experience these side effects, avoid driving or operating heavy machinery until these symptoms subside.
Use in Pregnancy and Lactation
Tocotrienols should be used with caution during pregnancy and breastfeeding. As such, it is generally advisable to consult a doctor before using these supplements during these conditions.
Caution in Other Conditions
Patients with bleeding disorders or those about to undergo surgery should exercise caution when taking Tocotrienols because they can slow blood clotting.
Similarly, individuals with liver disease should consult their doctor before starting Tocotrienols as there is limited research on its safety in these individuals.
Special Dietary and Lifestyle Recommendations
Consuming a diet rich in natural sources of Tocotrienols such as palm oil, rice bran oil, wheat germ, barley, and certain nuts and grains may boost your intake of these potent antioxidants.
Regular physical activity can support overall cardiovascular health and can work synergistically with the potential heart health benefits of Tocotrienols.
Reducing stress through practices like yoga, meditation or deep-breathing exercises can help support overall well-being and may enhance the potential benefits of Tocotrienols for brain health.
Frequently asked questions
Is Tocotrienols a hormone or a vitamin?
Tocotrienols are not hormones. They belong to the vitamin E family, which comprises of several compounds including tocopherols and four different forms of Tocotrienols: alpha, beta, gamma, and delta-tocotrienol.
Can Tocotrienols lead to fatigue or headaches?
While consumption of Tocotrienols is generally safe for most individuals when consumed appropriately, potential side effects may include fatigue and headaches. However, these side effects are less common at typical doses.
Does Tocotrienols have any impact on hair and skin health?
Emerging research suggests that Tocotrienols might promote younger-looking skin and hair by fighting free radical damage. However, more studies are needed to confirm these potential benefits.
Can Tocotrienols be taken if I am on anticoagulant or antiplatelet medications?
You should exercise caution while taking Tocotrienols if you are simultaneously on anticoagulant or antiplatelet medications, as Tocotrienols may slow blood clotting. It is advised to consult your doctor before starting any supplements.
Are there any natural food sources of Tocotrienols?
Yes, Tocotrienols can be found naturally in certain foods such as palm oil, rice bran oil, wheat germ, barley, and some nuts and grains.
Can Tocotrienols be used for brain health and cognitive decline?
Research suggests potential benefits of Tocotrienols for supporting brain health and potentially slowing cognitive decline. However, more extensive research is needed to confirm these effects.
Will applying tocotrienol cream to the skin cause itching?
Although rare, some people may experience mild itching when applying tocotrienol cream to the skin.
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