Thalidomide
Uses of Thalidomide
The primary role of Thalidomide is in the management of multiple myeloma, a type of blood cancer. It belongs to the category of immunomodulatory agents.
Secondary applications of Thalidomide include managing erythema nodosum leprosum (ENL), a painful skin complication associated with leprosy. Additionally, it may also be recommended in the management of other inflammatory conditions and cancers.
Side effects of Thalidomide
Drowsiness
Fatigue
Constipation
Skin rash and dryness
How Thalidomide works
Thalidomide is an immunomodulatory agent.
It works by enhancing the activity of immune cells such as T cells and natural killer cells, which play a crucial role in fighting unwanted cells in the body. Thalidomide also inhibits the production of certain substances called inflammatory cytokines, which are usually involved in causing inflammation and pain. Importantly, it prevents the growth of new blood vessels that supply nutrients to cancerous tumours, thereby slowing down their growth. Lastly, it induces apoptosis, which is the programmed death of cancer cells. This helps to reduce the number of harmful cells in the body.
Certified content
Written By
MD Ayurveda
Reviewed By
Bachelor of Dental Surgery
Expert Advice
Dosage Forms Available
Thalidomide can be taken orally (capsule or tablet).
Age and Dose Restrictions
Thalidomide is typically prescribed for adults.
Contraindications
Thalidomide is contraindicated in patients who have a known hypersensitivity to thalidomide or any of its components.
Other Medications to Avoid
This medicine may interact with sedatives (such as midazolam, and diazepam), anti-anxiety medications (like alprazolam, and lorazepam), antipsychotics (such as risperidone, and olanzapine), anti-convulsants (like phenytoin, and carbamazepine), chemotherapy medicines (like cisplatin, and doxorubicin), anti-HIV medicines (like zidovudine) and blood thinners (like warfarin).
Overdose and Missed Dose
Overdose of Thalidomide may cause severe dizziness, increased heart rate or fainting. If you observe these symptoms, inform your doctor immediately.
If you forget to take this medicine, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular schedule.
Management of Side Effects
Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.
For drowsiness or dizziness, avoid driving or doing anything that requires concentration until you feel better.
Drinking plenty of water can help manage constipation.
Use in Driving and Operating Machinery
Thalidomide may cause drowsiness or dizziness. If these symptoms occur, avoid driving or operating heavy machinery.
Use in Pregnancy and Lactation
Thalidomide is not recommended for use during pregnancy or breastfeeding due to the risk of severe harm to the baby. Consult your doctor before using this medicine if you are pregnant, planning a pregnancy or breastfeeding.
Caution in Other Conditions
Patients with a history of seizures or low white blood cell counts should exercise caution when taking Thalidomide.
Caution is also advised for patients with HIV infection due to potential interactions with antiretroviral medicines.
Special Dietary and Lifestyle Recommendations
Stay hydrated and drink plenty of water.
Regular monitoring of your health is important while taking this medicine.
Frequently asked questions
Can Thalidomide affect my mood or behaviour?
There is no significant evidence to suggest that Thalidomide directly affects mood or behaviour. But, some patients may experience drowsiness or fatigue which could indirectly affect mood. Always consult your doctor if you experience any unexpected changes.
Will Thalidomide make me gain weight?
Weight gain is not a common side effect of Thalidomide. However, everyone reacts differently to medication, so it's best to keep an eye on any changes and consult your doctor if you have concerns.
Is Thalidomide vegan-friendly?
Thalidomide is a chemical compound whose active ingredient does not contain animal products. However, capsules or tablets might contain non-vegan ingredients like gelatine. It is advisable to check the product label or consult your doctor for more information.
What is the half-life of Thalidomide?
Thalidomide has an elimination half-life of 5-7 hours, which means most of the medicine is eliminated from your body within 48 hours after stopping treatment.
Can I have a flu shot while using Thalidomide?
Live vaccines should be avoided during Thalidomide therapy. Inactivated vaccines, like the flu shot, may be safe, but you should always check with your doctor.
Can Thalidomide cause infertility?
There is no specific information available to suggest that Thalidomide causes infertility. However, if you have concerns regarding this, it would be advisable to consult with your doctor.
Does Thalidomide affect the menstrual cycle?
The scientific literature does not specifically mention any effects of Thalidomide on the menstrual cycle. However, hormonal imbalances may occur due to various health conditions or medicines. Always consult your doctor if you notice any changes in your menstrual cycle during treatment.
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