Sorafenib
Uses of Sorafenib
Sorafenib is primarily used to manage advanced kidney cancer (renal cell carcinoma), liver cancer (hepatocellular carcinoma) that cannot be treated with surgery, and thyroid cancer that has spread to other parts of the body. It belongs to the class of medications known as kinase inhibitors.
Side effects of Sorafenib
Skin rash, dryness, and itching
Hand-foot skin reaction
Diarrhoea
Fatigue and weakness
Hair loss (Alopecia)
How Sorafenib works
Sorafenib is a kinase inhibitor.
It functions by blocking the activities of abnormal proteins that signal cancer cells to multiply. This blockade helps to prevent the cancer from spreading. Specifically, it inhibits multiple intracellular and surface kinases, which play crucial parts in cancer cell signalling, angiogenesis (the process of new blood vessel formation), and apoptosis (the process of programmed cell death).
Certified content
Written By
Doctor of Medicine
Reviewed By
BMS, FMC, MD Resident
Expert Advice
Dosage Forms Available
Sorafenib is available in the dosage form of tablets. It is taken orally.
Age and Dose Restrictions
This medicine is meant for adults of age above 18 years.
Contraindications
Sorafenib is contraindicated in patients with known severe hypersensitivity to Sorafenib or any other components of the product.
Other Medications to Avoid
Sorafenib may interact with antibiotics (such as rifampin) and antifungals (such as ketoconazole).
Overdose and Missed Dose
An overdose of Sorafenib may cause severe health issues. If you suspect an overdose, it is important to seek immediate medical attention.
If you miss a dose of this medicine, take it as soon as you remember. Do not double the dose to make up for a missed dose.
Management of Side Effects
Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.
Drinking plenty of water can help manage side effects such as diarrhoea.
Taking the medicine with meals can help manage nausea and vomiting.
Resting and limiting physical activity can help manage fatigue and weakness.
Use in Driving and Operating Machinery
Sorafenib may cause dizziness or fatigue. Therefore, it is advised not to drive or operate heavy machinery if these symptoms are experienced.
Use in Pregnancy and Lactation
Women should avoid becoming pregnant while taking Sorafenib due to potential harm to the foetus. It is also not recommended for use while breastfeeding. It is advised to consult a doctor before using this medicine during pregnancy or lactation.
Caution in Other Conditions
Patients with heart problems, high blood pressure, and liver or kidney problems should exercise caution when taking this medicine.
Sorafenib may affect wound healing, so patients planning to undergo surgery should inform their doctor.
Special Dietary and Lifestyle Recommendations
Avoid consumption of grapefruit and grapefruit juice as they can affect the metabolism of Sorafenib.
Limit high-fat meals as they may reduce the absorption of the medicine.
Frequently asked questions
Does Sorafenib have any effect on sleep?
Sorafenib is not associated with affecting sleep. However, fatigue and weakness are common side effects, which could potentially affect sleep patterns. As always, it is best to discuss any concerns or symptoms with your doctor.
Will Sorafenib affect my fertility?
Sorafenib can cause harm to an unborn baby, so effective contraception is advised during treatment and for at least two weeks after the last dose. If you are planning to conceive, please consult your doctor.
Is it safe to take Sorafenib daily?
Yes, Sorafenib is usually taken orally without food, as per the doctor's recommendation. Treatment should continue until you are no longer clinically benefiting from therapy or until unacceptable toxicity occurs.
How soon can I expect results from taking Sorafenib?
Sorafenib starts working at the molecular level as soon as it is absorbed by the body to inhibit specific proteins involved in cancer growth. However, visible results in terms of cancer progression slowing down will vary from patient to patient.
I am a vegetarian. Does Sorafenib contain any animal-derived ingredients?
Sorafenib is a chemically synthesized medicine and does not contain any animal-derived ingredients. However, if you have any concerns about the excipients used in tablets, consult your doctor or pharmacist.
Can Sorafenib impact my mood or hormonal balance?
Sorafenib is not directly associated with influencing mood or hormones. However, certain side effects like fatigue, weight loss, and physical discomfort could indirectly affect your emotional well-being. Consult your doctor for further information.
Is Sorafenib considered an over-the-counter medicine?
Sorafenib is not an over-the-counter medicine; it requires a prescription from a doctor.
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