Selexipag
Uses of Selexipag
The primary use of Selexipag is in managing PAH in adults. This medication belongs to the group of selective non-prostanoid IP prostacyclin receptor agonists.
Side effects of Selexipag
Headache
Diarrhoea
Jaw pain
Nausea
Flushes
How Selexipag works
Selexipag is a selective non-prostanoid IP prostacyclin receptor agonist.
It acts by selectively activating the IP prostacyclin receptor. This leads to the widening of the pulmonary arteries, a process known as vasodilation.
In addition, it also inhibits the growth of vascular smooth muscle cells. Both these actions together help in reducing the high pressure in the pulmonary arteries seen in pulmonary arterial hypertension (PAH).
Furthermore, Selexipag is transformed into an active metabolite inside the body by an enzyme called carboxylesterase 1. This metabolite brings about similar beneficial effects, thereby boosting Selexipag's overall effectiveness in managing PAH.
Certified content
Written By
BDS, MDS
Reviewed By
BMS, FMC, MD Resident
Expert Advice
Dosage Forms Available
This medicine is available for oral use in the form of tablets.
Age and Dose Restrictions
This medicine is meant for use by adults only.
Contraindications
This medicine is contraindicated in patients with severe hepatic impairment (Child-Pugh class C).
Other Medications to Avoid
This medicine may interact with strong inhibitors of CYP2C8 (such as gemfibrozil) and moderate inhibitors of CYP2C8 (such as clopidogrel).
Overdose and Missed Dose
In case of an overdose, supportive measures should be taken as required, as there is no specific antidote. Dialysis is unlikely to be effective owing to the high plasma protein binding of Selexipag and its metabolite.
If a dose is missed, it should be taken as soon as you remember. However, skip the missed dose if it is almost time for your next scheduled dose. Do not take an extra dose to make up for the missed one.
Management of Side Effects
Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.
To manage headaches, consider adjusting the timing of your medication or increasing water intake.
For nausea or diarrhoea, it may help to take Selexipag with food and increase fluid intake, respectively.
Use in Driving and Operating Machinery
Selexipag may cause side effects like headache or flushing which could affect your ability to drive or operate heavy machinery. You should be cautious about driving or operating machinery until you know how this medicine affects you.
Use in Pregnancy and Lactation
The effects of Selexipag during pregnancy and lactation have not been sufficiently studied. Therefore, it is recommended to consult your doctor regarding its use if you are pregnant or breastfeeding.
Caution in Other Conditions
Patients with severe renal impairment should also exercise caution when using this medicine.
Special Dietary and Lifestyle Recommendations
Maintain a balanced diet rich in high-fibre foods, which can help manage potential gastrointestinal side effects like nausea or diarrhoea associated with Selexipag usage.
Regular physical activity can help improve cardiovascular health. Consult your doctor about suitable exercises that you can perform safely.
Avoid smoking and limit alcohol consumption as these can worsen symptoms of PAH.
Frequently asked questions
Is Selexipag a steroid?
No, it is not a steroid. It is a type of medicine known as a selective non-prostanoid IP prostacyclin receptor agonist.
Does Selexipag have any effect on sleep?
There is no evidence to suggest a specific impact of this medicine on sleep. However, any significant change in your sleeping patterns while taking this medicine should be discussed with your doctor.
Will Selexipag affect fertility?
The effects of this medicine on fertility has not been fully studied. If you have concerns about fertility, you should consult your doctor.
Are there any particular diet restrictions while taking Selexipag?
There is no evidence to suggest any specific dietary restrictions while taking this medicine. However, a healthy diet can contribute to overall well-being and may support your recovery process.
Is it safe to take Selexipag daily?
The frequency and dosage of this medication should be adhered to as prescribed by your doctor.
How much time does Selexipag take to work?
It reaches its peak plasma concentrations within 1 to 3 hours after oral administration. However, the length of time for the medicine to show its effect can vary depending on individual patient characteristics and the severity of the condition.
Can Selexipag cause hyperthyroidism?
Yes, hyperthyroidism, which is an overactive thyroid, has been reported in some people taking this medicine. Doctors typically monitor thyroid function as clinically indicated.
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