S-adenosyl Methionine
Uses of S-adenosyl Methionine
The main use of S-Adenosyl Methionine is for the management of liver diseases such as cirrhosis and cholestasis. It belongs to the group of hepatoprotective medicines.
S-Adenosyl Methionine is also indicated for use in depression and osteoarthritis. Preliminary studies have suggested its potential use in conditions like fibromyalgia, migraines, Alzheimer's, and ADHD, though more research is needed.
Side effects of S-adenosyl Methionine
Nausea
Diarrhoea
Abdominal discomfort
Headache
Insomnia
How S-adenosyl Methionine works
S-Adenosyl Methionine is a naturally occurring compound in the body.
It plays a crucial role in methylation processes, which involves adding a methyl group to various molecules in the body. Numerous compounds, including phospholipids, proteins, epinephrine, melatonin, and creatine, are produced by this process. It is also vital for the production of DNA and RNA nucleic acids.
Certified content
Written By
Doctor of Medicine
Reviewed By
BMS, FMC, MD Resident
Expert Advice
Dosage Forms Available
S-Adenosyl Methionine is available for oral administration in the form of tablets and capsules.
It can also be administered via intravenous or intramuscular injection.
Age and Dose Restrictions
S-Adenosyl Methionine is intended for use in adults and children above 18 years of age.
Contraindications
S-Adenosyl Methionine is contraindicated in patients with known allergies to this medicine or any of its components.
It is also contraindicated in patients with bipolar disorder due to the risk of triggering manic episodes.
Other Medications to Avoid
S-Adenosyl Methionine may interact with antidepressants (such as fluoxetine and sertraline), antiparkinson medications (such as levodopa), and opioid analgesics (like tramadol).
Overdose and Missed Dose
An overdose of S-Adenosyl Methionine may cause symptoms such as restlessness, anxiety, and headache. If you suspect an overdose, contact your doctor immediately.
If you forget to take your dose of this medication, take it as soon as you remember. However, if it is close to the time for your next dose, skip the missed dose and continue with your regular schedule.
Management of Side Effects
Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.
For instance, if you experience nausea or abdominal discomfort after taking S-Adenosyl Methionine, try taking it with a small meal or snack.
Drinking plenty of water may help reduce headaches or dizziness.
Use in Driving and Operating Machinery
S-Adenosyl Methionine may cause dizziness or sleepiness in some individuals. If you experience these side effects, avoid driving or operating heavy machinery.
Use in Pregnancy and Lactation
It is advised to consult a doctor before using S-Adenosyl Methionine during pregnancy or breastfeeding due to insufficient data on safety.
Caution in Other Conditions
Patients with liver disease should exercise caution when taking S-Adenosyl Methionine as it may impact liver functions.
Special Dietary and Lifestyle Recommendations
Ensure adequate hydration to facilitate the excretion of any excess S-Adenosyl Methionine from the body.
Aim to lead an active lifestyle with regular exercise, which can help manage conditions such as depression and osteoarthritis - conditions for which S-Adenosyl Methionine is often used.
Frequently asked questions
Is S-Adenosyl Methionine a naturally occurring compound?
Yes, S-Adenosyl Methionine is a naturally occurring compound in the body. It is involved in many biochemical reactions and is made from the amino acid methionine and ATP.
Does S-Adenosyl Methionine affect mood or mental health?
Yes, S-Adenosyl Methionine (SAMe) can affect mood and mental health. It is commonly used to support mood and alleviate symptoms of depression, as it plays a role in the production of neurotransmitters. However, consult your doctor before using it, especially if you have a mood disorder or are on other medications.
Can long-term use of S-Adenosyl Methionine cause dependency?
Long-term use of S-Adenosyl Methionine (SAMe) typically does not cause dependency. However, it's important to use it under medical supervision.
Does S-Adenosyl Methionine affect hormones?
S-Adenosyl Methionine plays a role in methylation, a process that influences many body functions including gene expression and protein function, which may indirectly impact hormone regulation.
Will taking S-Adenosyl Methionine cause any changes in appetite?
While some side effects like nausea and abdominal discomfort may potentially affect your appetite, there is no direct evidence linking S-Adenosyl Methionine to changes in appetite.
Do I need a prescription to purchase S-Adenosyl Methionine?
S-Adenosyl Methionine is sold as a dietary supplement, and generally, does not require a prescription. However, it is always advised to consult a doctor before starting any new medication or supplement.
How long does it take for S-Adenosyl Methionine to start working?
S-Adenosyl Methionine reaches peak levels 3-5 hours after ingestion. However, for certain conditions like depression or osteoarthritis, it may take several weeks of regular use to notice an effect.
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