Rucaparib
Uses of Rucaparib
The primary use of Rucaparib is for the management of specific types of cancers. These include ovarian cancer, fallopian tube cancer, peritoneal cancer, and metastatic castration-resistant prostate cancer. It belongs to a group of medications called poly ADP-ribose polymerase (PARP) inhibitors.
Side effects of Rucaparib
Fatigue
Nausea and vomiting
Constipation or diarrhoea
Stomach pain
Altered taste sensation
How Rucaparib works
Rucaparib is a poly ADP-ribose polymerase (PARP) inhibitor.
It functions by obstructing the PARP enzyme, a key player in the DNA repair process within cells. This obstruction makes it challenging for cancer cells to mend themselves, thereby preventing or decelerating their growth and propagation within the body.
Certified content
Written By
Doctor of Medicine
Reviewed By
BMS, FMC, MD Resident
Expert Advice
Dosage Forms Available
Rucaparib is available for use in the form of tablets which are intended for oral administration.
Age and Dose Restrictions
This medicine is intended for adults and children above 18 years of age.
Contraindications
Rucaparib is contraindicated in patients with known hypersensitivity to the ingredient itself.
It is also contraindicated in patients with severe hepatic impairment.
Other Medications to Avoid
Rucaparib may interact with several medications, including anticoagulants (such as warfarin), antifungal medicines (like fluconazole), proton pump inhibitors (such as omeprazole), and certain antidepressants (like fluoxetine).
Overdose and Missed Dose
Overdosing on Rucaparib can lead to serious side effects such as extreme fatigue, severe nausea, or unusual bruising or bleeding. If you suspect an overdose, seek immediate medical attention.
If you miss a dose of Rucaparib, take it as soon as you remember. However, if it is nearly time for your next dose, skip the missed dose and continue with your regular dosing schedule. Never take a double dose to make up for the missed one.
Management of Side Effects
Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.
Drinking plenty of water may help alleviate some mild digestive discomforts such as constipation or diarrhoea.
Resting and avoiding strenuous activities may help manage fatigue.
Sucking on sugar-free hard candies may help to relieve dry mouth.
Use in Driving and Operating Machinery
This medication may cause fatigue and dizziness, which may affect your ability to drive or operate heavy machinery. Avoid these activities if you experience these side effects.
Use in Pregnancy and Lactation
Rucaparib is not recommended for use during pregnancy or breastfeeding. If you are pregnant or nursing, it is advised to consult your doctor before taking this medicine.
Caution in Other Conditions
Patients with moderate hepatic impairment should exercise caution when taking Rucaparib. Dose adjustments may be necessary.
Patients with renal impairment should also proceed with caution as the effects of Rucaparib have not been studied extensively in this group.
Special Dietary and Lifestyle Recommendations
Eating a balanced diet rich in fruits and vegetables can help manage overall health and wellness during cancer treatment.
Regular mild physical activity, as tolerated, can help manage fatigue.
Avoiding direct sunlight or wearing protective clothing and sunscreen can minimise the risk of photosensitivity reactions.
Frequently asked questions
Can Rucaparib be purchased without a doctor's prescription?
No, Rucaparib cannot be purchased without a doctor's prescription. It is a potent medication used for managing specific types of cancers and should be taken under the supervision of a doctor.
Are there any natural alternatives to Rucaparib?
Currently, there are no known natural alternatives to Rucaparib that can manage the specific types of cancer that this medication is used for. Always consult your doctor before starting any alternative regimes.
Does Rucaparib cause mood changes?
While mood changes are not a common side effect of Rucaparib, every individual may react differently to medications. If you experience significant mood changes while taking this medication, consult your doctor immediately.
Does exposure to sunlight affect Rucaparib effectiveness?
Rucaparib may cause photosensitivity reactions; therefore, patients are advised to avoid sun exposure and use sunscreen and protective clothing when outdoors while taking this medication.
Does Rucaparib have an addiction potential?
No, Rucaparib does not have an addiction potential. It is a prescription medication used for managing certain types of cancers and does not contain substances that can cause dependency.
Does Rucaparib have any effect on the heart?
Like other medications, Rucaparib can affect different people in different ways. There may be potential heart-related side effects, so if you have a history of heart conditions, it is important to inform your doctor before starting this medication.
Does Rucaparib cause weight gain?
Weight changes are not typically associated with Rucaparib use. However, everyone's body responds differently to medicines. If you are concerned about weight changes while taking this medication, consult your doctor.
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