Prothionamide
Uses of Prothionamide
Prothionamide is primarily used to manage active medicine-resistant tuberculosis, a serious bacterial infection affecting the lungs primarily. It falls under the class of thioamides.
It is often used as part of a combination therapy in cases where the tuberculosis bacteria have developed resistance to first-line treatments. It may be included in treatment regimens for multi-medicine-resistant TB (MDR-TB) or extensively medicine-resistant TB (XDR-TB).
Side effects of Prothionamide
Nausea and vomiting
Loss of appetite
Metallic taste in the mouth
Drowsiness
Numbness or tingling sensation in hands and feet
How Prothionamide works
Prothionamide is a type of medicine called a thioamide antibiotic.
It works by inhibiting the synthesis of mycolic acids, essential components of the bacterial cell wall in Mycobacterium tuberculosis. This disruption weakens the cell wall, leading to bacterial death and helping to control the infection.
Certified content
Written By
BDS, MDS
Reviewed By
BMS, FMC, MD Resident
Expert Advice
Dosage Forms Available
Prothionamide is available in tablet form. These tablets are intended for oral administration.
Age and Dose Restrictions
This medicine is meant for adults and children over 12 years of age.
Contraindications
This medicine is contraindicated in patients with severe liver disease or acute liver failure.
It is also contraindicated in patients with pre-existing liver impairment.
Other Medications to Avoid
This combination may interact with other anti-tuberculosis medications (such as isoniazid), antibiotics (like cycloserine), thyroid medications (such as thyroxine), and gastrointestinal agents (sucralfate).
Overdose and Missed Dose
An overdose of Prothionamide may lead to severe adverse effects such as liver injury or psychiatric symptoms. Immediate medical attention should be sought if an overdose is suspected.
If you miss a dose of Prothionamide, take it as soon as you remember. However, if it is nearly time for the next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for the missed one.
Management of Side Effects
Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.
To manage gastrointestinal disturbances like nausea or vomiting, try taking Prothionamide with food.
A metallic taste in the mouth may be lessened by rinsing your mouth after taking the medication.
Use in Driving and Operating Machinery
Prothionamide may cause dizziness or drowsiness. Avoid driving or operating heavy machinery if you experience these symptoms after taking this medicine.
Use in Pregnancy and Lactation
Prothionamide is not recommended during pregnancy unless needed due to potential risks to the fetus.
It is advisable to avoid breastfeeding while taking this medicine as it enters breast milk.
Caution in Other Conditions
Patients with diabetes should monitor their blood glucose levels closely as Prothionamide may lower blood sugar levels.
Those with a history of psychiatric conditions should also exercise caution due to the potential for psychiatric effects from Prothionamide.
Special Dietary and Lifestyle Recommendations
Patients taking Prothionamide should regularly monitor their liver function through blood tests, as liver health can be adversely affected by this medication.
It is advisable to limit alcohol consumption because alcohol can increase the risk of liver toxicity when taking Prothionamide.
Maintaining adequate hydration can help manage some side effects such as nausea or dizziness.
Since tuberculosis is a contagious disease, adhering strictly to your prescribed medication regimen is crucial not only for your health but also to prevent the spread of infection to others.
Frequently asked questions
Is Prothionamide a steroid?
No, Prothionamide is not a steroid. It belongs to a class of medications known as thioamides, which are antibacterial medicines primarily used to manage tuberculosis.
Does Prothionamide have any effect on sleep?
Although drowsiness is a common side effect of Prothionamide, it does not typically alter the sleep cycle. However, if you experience extreme fatigue or drowsiness, it is crucial to consult with your doctor.
Will Prothionamide affect fertility?
There is no definitive scientific evidence suggesting that Prothionamide directly affects fertility in men or women. However, if you are planning to conceive and are on Prothionamide medication, you should discuss this with your doctor.
Are there any particular diet restrictions while taking Prothionamide?
There are no specific diet restrictions while taking Prothionamide. However, it is recommended to take the medicine with food to minimise gastrointestinal side effects such as nausea and vomiting.
Is it safe to take Prothionamide daily?
Yes, it is safe to take Prothionamide daily as prescribed by your doctor. It is important to follow the prescribed dosage and schedule for optimal management of tuberculosis.
How much time does Prothionamide take to work?
Prothionamide begins working soon after oral administration by inhibiting the synthesis of mycolic acids in the bacteria causing tuberculosis. However, as it is usually part of a long-term treatment regimen for medication-resistant TB, visible improvement in symptoms may take several weeks.
What is the best time to take Prothionamide?
The best time to take Prothionamide will be prescribed by your doctor.
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