Posaconazole
Uses of Posaconazole
Posaconazole is used for managing severe fungal infections, especially in patients whose immune system is compromised and this medication belongs to the category of azole antifungal agents.
Posaconazole is also used for the prevention of invasive Aspergillus and Candida infections in high-risk patients such as those with prolonged neutropenia (rare blood disorder and immunodeficiency that occurs when a person has low levels of neutrophils) or hematopoietic stem cell transplant recipients. Furthermore, it is used for the management of invasive aspergillosis (fatal fungal infection that occurs in people with weakened immune systems) in patients who are resistant to or intolerant of amphotericin B, itraconazole, or voriconazole.
Side effects of Posaconazole
Nausea
Vomiting
Diarrhoea
Abdominal pain
Headache
How Posaconazole works
Posaconazole is a triazole antifungal medication.
It works by inhibiting an enzyme called lanosterol 14α-demethylase in the fungi. This enzyme plays a crucial role in the production of a substance called ergosterol, which forms a vital part of the fungal cell membrane. By blocking this enzyme, this disrupts the production of ergosterol, leading to damage to the fungal cell membrane. This results in the stunting of fungal growth and activity, helping to manage a wide range of severe fungal infections.
Certified content
Written By
BDS, MDS
Reviewed By
Bachelor of Dental Surgery
Expert Advice
Dosage Forms Available
Posaconazole is available in multiple dosage forms, including suspension and tablet.
Age and Dose Restrictions
Posaconazole is intended for use in adults and children 13 years of age and older depending on the dosage.
Contraindications
Posaconazole is contraindicated in patients with a known hypersensitivity to the medication or any of its components. It is also contraindicated in patients with fructose intolerance or a prolonged QT interval (a rare heart problem that may cause irregular heartbeat, fainting, or sudden death.
Other Medications to Avoid
Posaconazole may interact with several medications, including terfenadine and astemizole (both used for allergies), cisapride (used for stomach issues), pimozide (used to treat Tourette's and certain mental health conditions), halofantrine (used for malaria), and quinidine (used for irregular heart rhythms).
Overdose and Missed Dose
Overdose of Posaconazole may result in symptoms such as headache, nausea, and vomiting. If you suspect an overdose, seek immediate medical attention.
If you miss a dose, take it as soon as you remember. However, if it is close to the time for your next dose, skip the missed dose and continue with your regular dosing schedule.
Management of Side Effects
Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.
Taking the medication with meals may help reduce gastrointestinal discomfort.
Use in Driving and Operating Machinery
Posaconazole may cause dizziness or fatigue in some individuals. If you feel dizzy or fatigued after taking this medication, avoid driving or operating heavy machinery.
Use in Pregnancy and Lactation
The use of Posaconazole in pregnancy and breastfeeding should only be considered if the potential benefit justifies the potential risk to the baby. Always consult your doctor before using Posaconazole during pregnancy or breastfeeding.
Caution in Other Conditions
Patients with liver disease should be cautious while taking Posaconazole as it can affect the liver function. The medication should also be used with caution in patients with heart conditions due to the risk of QT prolongation.
Special Dietary and Lifestyle Recommendations
You can continue your usual diet unless your doctor advises otherwise.
During yeast infections, it's recommended to follow a candida diet, which avoids sugar, gluten, certain dairy products, and alcohol, and focuses on low-sugar fruits, non-starchy vegetables, and gluten-free foods.
Frequently asked questions
Can Posaconazole help against all types of fungal infections?
Posaconazole is effective against a broad spectrum of fungal pathogens, including Aspergillus and Candida infections. However, it might not work against all types of fungi and its usage should be based on doctor's advice.
Does Posaconazole have any effect on mood or hormones?
There is no research data to support the specific effects of Posaconazole on mood or hormones. For any unusual symptoms, consult with your doctor immediately.
Can Posaconazole be taken without a meal?
The oral suspension form of Posaconazole should be taken with food or a nutritional supplement for better absorption. However, the delayed-release tablet can be taken with or without food.
Is Posaconazole a steroid?
No, Posaconazole is not a steroid. It is an antifungal medicine used to prevent and manage severe fungal infections.
Is it safe to take Posaconazole daily?
Yes, it is safe to take Posaconazole daily as long as it is under the direction and supervision of your doctor.
Will Posaconazole affect fertility?
No specific information about the effects of Posaconazole on fertility is available from the references provided.
What is the best time to take Posaconazole?
Posaconazole can be taken at any time that suits your schedule, but it should be taken with food or a nutritional supplement for better absorption.
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