Perampanel
Uses of Perampanel
Perampanel is primarily used for the management of partial-onset seizures (focal seizures), with or without secondarily generalised seizures, and primary generalised tonic-clonic seizures in people with epilepsy. This medication belongs to the class of medicines known as AMPA receptor antagonists.
Side effects of Perampanel
Dizziness
Drowsiness
Fatigue
Mood changes
Weight gain
How Perampanel works
Perampanel is an anticonvulsant medicine.
Its action is due to its property as an AMPA receptor antagonist. In simpler terms, it acts by selectively blocking a type of receptor in the brain known as the AMPA (α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid) receptor. These AMPA receptors play an important role in transmitting electrical signals between nerve cells. When these receptors are blocked, Perampanel reduces the excessive excitation of nerve cells that is responsible for seizures. By doing so, Perampanel helps to prevent or reduce the frequency and severity of seizures in patients with epilepsy.
Certified content
Written By
MD Ayurveda
Reviewed By
BMS, FMC, MD Resident
Expert Advice
Dosage Forms Available
Perampanel can be taken orally (tablet and suspension).
Age and Dose Restrictions
This medicine is approved for use in adults and children.
Contraindications
Perampanel should not be used in patients who have a known hypersensitivity to this medication or any of its inactive ingredients. It is also contraindicated in patients with severe liver impairment.
Other Medications to Avoid
Perampanel may interact with other anticonvulsants (such as carbamazepine, oxcarbazepine, phenytoin) and CYP3A4 inducers (such as rifampin and St. John's wort).
Overdose and Missed Dose
An overdose of Perampanel can lead to severe drowsiness, dizziness, and changes in mood or behaviour. If you suspect that you have taken more than the recommended dose, seek medical help immediately.
If you miss a dose of Perampanel, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.
Management of Side Effects
Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.
If Perampanel causes dizziness or drowsiness, it may be helpful to take it at bedtime.
Drinking plenty of water can help to manage the side effects of nausea and vomiting.
Use in Driving and Operating Machinery
Perampanel may affect your ability to drive or operate heavy machinery. Avoid these activities if you feel dizzy or drowsy after taking this medication.
Use in Pregnancy and Lactation
Perampanel should not be used during pregnancy unless the benefits clearly outweigh the risks, as it may harm the foetus. Women should discuss the risks and benefits with their doctor before breastfeeding while using this medicine.
Caution in Other Conditions
Caution should be exercised when using Perampanel in patients with a history of psychiatric disorders, aggressive behaviour, suicidal thoughts, or substance abuse.
Elderly patients and those with liver or kidney impairment should also use this medicine with caution.
Special Dietary and Lifestyle Recommendations
Stress management techniques, such as mindfulness and relaxation exercises, can be beneficial.
Regular check-ups are important to monitor the effectiveness of the medication and manage any potential side effects.
Frequently asked questions
Is Perampanel a mood stabiliser?
No, Perampanel is not a mood stabiliser. It is an anticonvulsant medicine used to manage certain types of seizures in people with epilepsy.
Does the Perampanel have any effect on menstruation cycle?
Perampanel itself does not directly affect the menstruation cycle. However, it can interact with hormonal contraceptives, potentially leading to changes in the menstrual cycle. It is best to discuss this with your doctor.
Will Perampanel affect mood or behaviour?
Perampanel can cause side effects such as irritability, aggression, anxiety, and mood changes. Serious side effects include severe mood or behaviour changes and suicidal thoughts or actions. If you experience any of these side effects, seek immediate medical attention.
Are there any natural alternatives to Perampanel?
There are no natural alternatives that have been proven to have the same effect as Perampanel in managing seizures. It is important not to stop taking Perampanel or change your treatment plan without consulting your doctor.
Can Perampanel cause weight gain?
One of the common side effects of Perampanel can be weight gain. If you notice significant weight gain while taking this medication, consult your doctor.
What is the best time to take Perampanel?
Perampanel is usually taken as per your doctor's instructions.
Is Perampanel a steroid?
No, Perampanel is not a steroid. It is an anticonvulsant medication used in the management of certain types of seizures in individuals with epilepsy.
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