Pazopanib
Uses of Pazopanib
The primary use of Pazopanib is to manage certain types of cancers, specifically advanced renal cell carcinoma and advanced soft tissue sarcoma. It belongs to a group of medicines known as tyrosine kinase inhibitors.
There are no secondary uses mentioned for this medication. It is primarily used for the management of the aforementioned types of cancers.
Side effects of Pazopanib
Diarrhoea
High blood pressure (hypertension)
Changes in hair colour
Nausea
Fatigue
How Pazopanib works
Pazopanib is categorised as a tyrosine kinase inhibitor.
It works by inhibiting multiple tyrosine kinases involved in tumour growth and blood vessel formation, including vascular endothelial growth factor (VEGF) receptors. This action helps to slow down or stop the growth of cancer cells and the development of new blood vessels that tumours need to grow.
Certified content
Written By
MSc (Applied Genetics)
Reviewed By
BMS, FMC, MD Resident
Expert Advice
Dosage Forms Available
Pazopanib is available in oral form as tablets. This medication is taken via the oral route.
Age and Dose Restrictions
Pazopanib is meant for adults (18 years and above).
Contraindications
Pazopanib is contraindicated in patients with hypersensitivity to pazopanib or any of its components.
Patients with severe hepatic impairment should not take Pazopanib.
Other Medications to Avoid
Pazopanib may interact with strong CYP3A4 inhibitors (such as ketoconazole, ritonavir, clarithromycin) and strong CYP3A4 inducers (such as rifampin).
It is essential to consult your doctor before starting any prescription or over-the-counter medications.
Overdose and Missed Dose
Overdosing on Pazopanib can lead to severe side effects. If an overdose is suspected, seek immediate medical attention.
If you miss a dose of Pazopanib, take it as soon as you remember unless it is close to the time for your next dose. Do not double up doses.
Management of Side Effects
Most side effects are temporary and generally harmless and dissolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.
For nausea or vomiting, try taking the medication with a small snack or sip on ginger tea.
If diarrhoea persists, stay hydrated by drinking lots of fluids.
For fatigue, try taking short naps throughout the day.
Use in Driving and Operating Machinery
Pazopanib may cause dizziness or fatigue which may affect your ability to drive or operate machinery. You should avoid doing so if these effects occur after taking this medicine.
Use in Pregnancy and Lactation
Pazopanib can cause foetal harm and is not recommended during pregnancy. It is also not recommended for use while breastfeeding. Always consult your doctor before taking Pazopanib if you are pregnant or breastfeeding.
Caution in Other Conditions
Patients with hepatic impairment should exercise caution when taking Pazopanib. Regular monitoring of liver function is recommended during treatment.
Special Dietary and Lifestyle Recommendations
Maintain a balanced diet rich in fruits, vegetables, lean proteins, and whole grains to support overall health.
Stay hydrated by drinking plenty of fluids, especially if experiencing side effects like diarrhoea or vomiting.
Regular light exercise can help manage fatigue and improve overall well-being. But always take it easy and rest when needed.
Avoid smoking and limit alcohol consumption, as these can increase the risk of some of the side effects of Pazopanib.
Frequently asked questions
Is Pazopanib a steroid?
No, Pazopanib is not a steroid. It is a medication that belongs to a group of medicines known as tyrosine kinase inhibitors. These are used to manage certain types of cancers, particularly advanced renal cell carcinoma (kidney cancer) and advanced soft tissue sarcoma.
Does Pazopanib have any effect on sleep?
There is no specific evidence to suggest that Pazopanib directly affects sleep. However, some side effects of the medication, such as fatigue, might indirectly influence your sleep patterns. If you are experiencing problems with sleep after starting this medication, you should consult your doctor.
Will Pazopanib affect fertility?
Pazopanib may potentially affect fertility in both men and women. If you're concerned about its impact on fertility, it's best to discuss your situation with your doctor.
Can I take herbal supplements while taking Pazopanib?
Certain herbal supplements may interact with Pazopanib, possibly affecting its efficacy or leading to adverse reactions. Always consult your doctor before starting any new supplements while on this medication.
Is it safe to take Pazopanib daily?
Yes, it is safe to take Pazopanib daily as long as you follow your doctor's prescription instructions. This medication is typically prescribed to be taken once per day.
How much time does Pazopanib take to work?
Pazopanib typically takes several weeks to a few months to show noticeable effects, as it gradually works to inhibit tumor growth. Your doctor can provide a more specific timeline based on your individual response and treatment plan.
What is the duration of treatment with Pazopanib?
The duration of treatment with Pazopanib varies from person to person and depends on the individual's response to the medication and the side effects experienced. Your doctor will determine the appropriate treatment duration for your specific situation.
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