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Ormeloxifene

Uses of Ormeloxifene

  • Ormeloxifene is primarily used as a non-hormonal, non-steroidal oral contraceptive and belongs to the group of Selective Estrogen Receptor Modulators (SERMs).

  • It also shows promise in managing other estrogen-related conditions like menstrual disorders, endometriosis, fibroids, and potentially, breast cancer.

Side effects of Ormeloxifene

  • Irregular menstrual bleeding

  • Nausea

  • Headache

  • Weight gain

How Ormeloxifene works

  • Ormeloxifene is a Selective Estrogen Receptor Modulator (SERM).

  • It binds to oestrogen receptors in various tissues and inhibits oestrogen effects in the uterus and breast, reducing cell proliferation and modulating hormone activity. This action helps in managing conditions like dysmenorrhea and preventing unwanted pregnancies.

Certified content

Written By

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Dr. Michelle FrankMedical Content Writer| 8 Years

Doctor of Medicine

Reviewed By

Dr. Chhavi Rosha
Dr. Chhavi Rosha Health & Medical Content Writer| 8 Years

BMS, FMC, MD Resident

Expert Advice

Dosage Forms Available

  • Ormeloxifene is available for use via the oral route in the form of tablets.

Age and Dose Restrictions

  • Ormeloxifene is intended for use by adult women.

Contraindications

  • This medicine is contraindicated in people with active liver disease or a history of jaundice.

Other Medications to Avoid

  • Ormeloxifene can interact with hormonal contraceptives (such as ethinyl estradiol, levonorgestrel), anticoagulants (such as warfarin, rivaroxaban), and medications affecting liver enzymes (such as rifampin, ketoconazole). It may also interact with other SERMs (such as tamoxifen, raloxifene) and anti-estrogenic agents.

Overdose and Missed Dose

  • An overdose of Ormeloxifene may cause severe nausea, vomiting, and vaginal bleeding. Very high doses can potentially lead to blood clots and liver injury. If you suspect an overdose, seek immediate medical attention.

  • If you miss a dose of Ormeloxifene, take it as soon as you remember. However, maintain a gap of at least 7 days before the next dose.

Management of Side Effects

Most side effects such as irregular menstrual bleeding, nausea, headache, and weight gain are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any of these symptoms, please consult your doctor.

  • Drinking plenty of water may help manage the side effect of nausea.

Use in Driving and Operating Machinery

  • Ormeloxifene does not usually interfere with the ability to drive or operate machinery. However, if you feel dizzy after taking this medication, avoid driving or operating heavy machinery.

Use in Pregnancy and Lactation

  • Ormeloxifene is not recommended for use during pregnancy as it may harm the foetus. While a small amount of the medicine may pass into breast milk, it is considered compatible with breastfeeding. However, always consult your doctor before using Ormeloxifene during pregnancy or while breastfeeding.

Caution in Other Conditions

  • People with clotting disorders or risk factors for blood clots such as smoking and immobility should exercise caution when taking Ormeloxifene.

Special Dietary and Lifestyle Recommendations

  • As Ormeloxifene does not protect against sexually transmitted infections, ensure to use additional contraceptive measures as needed.

  • If you have a clotting disorder or risk factors for blood clots such as smoking and lack of movement, consider incorporating light exercise into your daily routine to improve circulation.

  • If you experience weight gain while taking Ormeloxifene, try to maintain a balanced diet and regular exercise regimen to manage your weight.

Frequently asked questions

No, Ormeloxifene is not a steroid. It is a selective oestrogen receptor modulator (SERM) which is primarily used as a non-hormonal, non-steroidal oral contraceptive.

There is no documented evidence to suggest that Ormeloxifene directly affects sleep. However, individual reactions can vary and any concerns should be discussed with your doctor.

Ormeloxifene acts as a contraceptive by making the endometrium (uterine lining) unreceptive to embryo implantation. This means it can prevent pregnancy while you are taking it. However, it does not inhibit ovulation, suggesting that normal fertility may resume once you stop taking the medicine.

There are no specific dietary restrictions required while taking Ormeloxifene. It can be taken with or without food.

It is essential to follow your doctor's instructions regarding the dosage and frequency of this medicine.

Ormeloxifene reaches peak blood concentrations about 4 hours after oral administration. However, steady-state levels, where the medicine is most effective, are achieved by the second week of dosing.

There are no specific recommendations regarding the best time of day to take Ormeloxifene. It can be taken with or without food as per your convenience, but it is important to maintain regularity with your doses.

Terms & Conditions

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