Mexiletine
Uses of Mexiletine
The primary use of Mexiletine is to manage ventricular arrhythmias (irregular heartbeats originating in the ventricles of the heart). It belongs to the class of medications known as class 1B antiarrhythmic agents.
Besides managing ventricular arrhythmias, Mexiletine is also used for managing chronic pain, especially in cases of peripheral neuropathy. It has applications in managing myotonic dystrophy to relieve muscle pain and severe myotonia (muscle stiffness and difficulty relaxing muscles). It can also be used for preventing sudden cardiac death in individuals with a history of serious ventricular arrhythmias.
Side effects of Mexiletine
Nausea and vomiting
Heartburn and diarrhoea
Dizziness and tremors
Chest pain and palpitations
How Mexiletine works
Mexiletine is a class 1B antiarrhythmic agent.
This medicine primarily works by blocking the sodium channels in heart muscle cells. By doing this, it slows down the electrical impulses that cause the heart muscle to contract.
Certified content
Written By
Doctor of Medicine
Reviewed By
BMS, FMC, MD Resident
Expert Advice
Dosage Forms Available
Mexiletine is available for use via oral route (capsules).
Age and Dose Restrictions
Mexiletine is generally prescribed for adults of age above 18 years.
Contraindications
Mexiletine is contraindicated in patients with second or third-degree heart block (unless they have a pacemaker).
This medicine should not be used by individuals who are hypersensitive to Mexiletine or any of its components.
Patients with cardiogenic shock should not take this medicine.
Other Medications to Avoid
Mexiletine may interact with other antiarrhythmic agents (such as quinidine, procainamide and disopyramide), beta-blockers (such as propranolol and metoprolol) and CYP2D6 inhibitors (such as fluoxetine and paroxetine).
Overdose and Missed Dose
An overdose of Mexiletine may cause severe cardiovascular effects like hypotension, bradycardia, and conduction disturbances. Neurological and gastrointestinal effects may also occur. Immediate medical attention is required in case of an overdose.
If you miss a dose of Mexiletine, take it as soon as you remember. However, if it is close to the time for your next dose, skip it and continue with your regular schedule. Do not double up on doses.
Management of Side Effects
Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.
Taking Mexiletine with food or an antacid can help minimise gastrointestinal side effects like nausea, vomiting, and heartburn.
Avoid rising abruptly from a sitting or lying position to prevent dizziness and lightheadedness.
Use in Driving and Operating Machinery
Mexiletine may cause dizziness, lightheadedness, and impaired coordination. If you feel these effects, it is advised not to drive or operate heavy machinery.
Use in Pregnancy and Lactation
It is advised to consult your doctor before using this medication if you are pregnant, planning for pregnancy, or breastfeeding.
Caution in Other Conditions
Patients with pre-existing liver or kidney disease should exercise caution when taking Mexiletine as it is metabolised by the liver and excreted by the kidneys.
Special Dietary and Lifestyle Recommendations
Maintain a healthy heart-friendly diet. Include more whole grains, fruits, vegetables, lean proteins, and low-fat dairy products in your meals.
Limit the intake of saturated fats, trans fats, cholesterol, sodium (salt), and added sugars.
Regular moderate physical activity can help maintain a healthy heart. However, contact your doctor before starting a new exercise regime.
Frequently asked questions
Is Mexiletine a type of steroid?
No, Mexiletine is not a steroid. It is a class 1B antiarrhythmic agent.
Does Mexiletine have any impact on sleep patterns?
Some patients might experience neurological side effects like dizziness, nervousness, and possibly mild disruptions in sleep. If you notice such issues, consult your doctor.
Can Mexiletine affect fertility in any way?
Mexiletine is not directly associated with affecting fertility. However, if you have concerns, please discuss them with your doctor.
Is it safe to take Mexiletine every day?
Mexiletine should be taken exactly as prescribed by your doctor. The safety of daily use depends on your health condition and how well your body responds to the medicine.
How long does it take for Mexiletine to start working?
The time for Mexiletine to show effects can vary from person to person. Your doctor will be able to give you a more accurate estimate based on your specific health condition.
Are natural alternatives available for Mexiletine?
Natural alternatives to Mexiletine are not usually recommended as this medicine is particularly effective in managing life-threatening ventricular arrhythmias. You should always consult your doctor before starting any alternative treatments.
Is Mexiletine available over the counter, or do I need a prescription?
Mexiletine is a prescription medication and is not available over the counter.
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