Metolazone
Uses of Metolazone
Used mainly to manage high blood pressure and reduce swelling and fluid retention caused by certain conditions, Metolazone belongs to a class of medicines called diuretics.
It is also prescribed for oedema associated with congestive heart failure, kidney disease and nephrotic syndrome.
Side effects of Metolazone
Dizziness
Light-headedness
Headache
Blurred vision
Loss of appetite
How Metolazone works
Metolazone is a diuretic, often referred to as a "water pill".
Its primary function is to act on the kidneys, prompting them to increase the production of urine. This increased output of urine helps the body to expel excess salt and water. The removal of these surpluses leads to a reduction in the volume of fluid in the body. This process helps to lower blood pressure and alleviate swelling, or oedema, caused by conditions like heart failure or kidney disease.
Certified content
Written By
Doctor of Medicine
Reviewed By
BAMS, APG, PG
Expert Advice
Dosage Forms Available
Metolazone is available in tablet form for oral administration.
Age and Dose Restrictions
This medication is generally meant for adults.
Contraindications
Metolazone is contraindicated in patients with hypersensitivity to this medication or its components. It is also contraindicated in patients with anuria, a condition where the kidneys fail to produce urine.
Other Medications to Avoid
Metolazone can interact with Nonsteroidal anti-inflammatory drugs (NSAIDs) (e.g., ibuprofen, naproxen, digoxin, and insulin).
Overdose and Missed Dose
An overdose of Metolazone may cause symptoms including profound dizziness, fainting, excessive urination, severe electrolyte imbalance or cardiovascular collapse. In such cases, seek immediate medical attention.
If you miss a dose of Metolazone, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed one and continue with your regular schedule.
Management of Side Effects
Most side effects are temporary and generally harmless and resolve when discontinuing Metolazone. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.
Drinking plenty of water may help manage side effects such as dizziness and headache.
Taking Metolazone with food may help manage stomach upset.
Use in Driving and Operating Machinery
As Metolazone may cause dizziness or light-headedness, it could potentially affect your ability to drive or operate heavy machinery. Exercise caution in these activities until you know how Metolazone affects you.
Use in Pregnancy and Lactation
Metolazone is not recommended during pregnancy and lactation unless recommended by your doctor. Consult your doctor before taking this medicine during pregnancy or breastfeeding.
Caution in Other Conditions
Patients with liver disease, kidney dysfunction, untreated mineral imbalance, gout, or lupus erythematosus should exercise caution when taking Metolazone. Diabetic patients should monitor their blood sugar levels closely while using Metolazone.
Special Dietary and Lifestyle Recommendations
Reduce your intake of foods high in sodium to help manage high blood pressure and fluid retention.
Regularly monitor your weight; sudden gain may indicate fluid retention and require treatment adjustments.
Frequently asked questions
Does Metolazone have any effect on sleep?
Metolazone usually does not affect sleep, but taking it in the morning is recommended to prevent frequent nighttime urination that could disrupt sleep.
Will Metolazone affect fertility?
Metolazone is not known to affect fertility. However, if you have concerns about fertility, it is important to consult your doctor.
Is it safe to take Metolazone daily?
Yes, only if your doctor prescribes it. Follow your doctor's instructions regarding dosage and frequency.
How much time does Metolazone take to work?
The time it takes for Metolazone to work can vary depending on the individual and the condition being managed. However, diuretic effects usually begin within the first hour after oral administration.
What is the best time to take Metolazone?
The best time to take Metolazone is usually in the morning. This helps to avoid frequent urination at night.
What is the duration of treatment with Metolazone?
The duration of treatment with Metolazone depends on the condition being managed and the patient's individual response to therapy. Always follow your doctor's instructions regarding the duration of treatment.
Is Metolazone available over the counter, or do I need a prescription?
Metolazone usually requires a prescription and is not available over the counter.
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