Mephentermine
Uses of Mephentermine
Mephentermine is chiefly used to manage clinically significant low blood pressure. It falls under the category of vasopressor and cardiac stimulant medicines.
It is also used in maintaining adequate blood pressure and circulation during a cardiac arrest, as an adjunct to fluid replacement. Another off-label usage of Mephentermine is reversing the hypotensive effects of certain anaesthetic agents.
Side effects of Mephentermine
Headache
Tremors
Rapid heartbeat
Nausea and vomiting
Dizziness and restlessness
How Mephentermine works
Mephentermine is a vasopressor and stimulant.
It works by stimulating the heart and constricting blood vessels, which increases blood pressure and improves blood flow.
Certified content
Written By
BDS, MDS
Reviewed By
BMS, FMC, MD Resident
Expert Advice
Dosage Forms Available
Mephentermine is available as an injectable solution. It is administered either intramuscularly or by slow intravenous infusion.
Age and Dose Restrictions
Mephentermine is meant for use in adults only.
Contraindications
Mephentermine is contraindicated in individuals with tachyarrhythmias or ventricular arrhythmias, severe coronary artery disease, and angle-closure glaucoma. It should not be used during cyclopropane or halogenated anaesthesia.
Other Medications to Avoid
This medicine may interact with monoamine oxidase inhibitors (such as phenelzine and tranylcypromine), tricyclic antidepressants (like amitriptyline, and clomipramine), ergot alkaloids (such as ergotamine), and oxytocic medicines (like oxytocin).
Overdose and Missed Dose
Symptoms of overdose include hypertensive crisis, cerebrovascular accidents, myocardial ischemia, psychosis, and seizures. Immediate medical intervention is crucial.
If a dose of Mephentermine is missed, administer as soon as remembered but avoid doubling the dosage. Regular scheduling should be resumed thereafter.
Management of Side Effects
Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.
Adjust the timing of medication to avoid insomnia if it causes restlessness or sleep disturbances when administered late in the day.
If experiencing dizziness, ensure adequate hydration by drinking water regularly.
Use in Driving and Operating Machinery
Mephentermine may affect abilities to drive or operate heavy machinery due to potential side effects like dizziness or restlessness. Caution is advised.
Use in Pregnancy and Lactation
Mephentermine is not recommended during pregnancy and lactation unless explicitly advised by a doctor. Consult your doctor for guidance before use if you are pregnant or breastfeeding.
Caution in Other Conditions
Individuals with severe renal impairment or those with a history of psychiatric disorders should use Mephentermine with caution.
Care should also be exercised in geriatric patients due to increased sensitivity to the medicine's effects.
Special Dietary and Lifestyle Recommendations
Avoid tyramine-rich foods such as aged cheeses, smoked or cured meats, and certain alcoholic beverages to prevent hypertensive crises.
Maintain adequate hydration especially if experiencing side effects such as sweating or nausea.
Engage in stress reduction techniques like meditation or gentle yoga to manage symptoms of restlessness or anxiety induced by Mephentermine.
Ensure a well-balanced diet to support overall health and recovery, particularly if recovering from conditions that required the use of Mephentermine.
Frequently asked questions
Is Mephentermine used as an anabolic steroid?
No, Mephentermine is not an anabolic steroid. It is a type of medicine called a sympathomimetic amine and is primarily used to manage low blood pressure.
Can Mephentermine disrupt my sleep?
Mephentermine can potentially cause restlessness and insomnia as side effects in some people. However, everyone reacts differently to medicines, so this may not be the case for all.
Does Mephentermine play any role in fertility?
There is no concrete scientific evidence suggesting that Mephentermine affects fertility. However, if you are planning to conceive and have concerns about this, please consult your doctor before starting this medication.
Are there any specific foods I should avoid while on Mephentermine?
Patients on Mephentermine should avoid tyramine-rich foods as they can cause a sudden and dangerous increase in blood pressure known as a hypertensive crisis.
Is it safe to use Mephentermine every day?
The safety of daily use of Mephentermine depends on the individual patient's health condition and the doctor's recommendation. Always follow your doctor's guidance about how to use this medicine.
How long does it take for Mephentermine to start working?
After administration, Mephentermine starts working within 5-15 minutes if given intramuscularly (injected into a muscle) and even faster if given intravenously (injected into a vein).
Is there an ideal time to administer Mephentermine?
Mephentermine is usually administered when there is a need to manage low blood pressure, particularly in emergency situations such as during surgery. There isn't an 'ideal time' per se as its usage is dependent on the specific medical circumstance at hand.
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