Hydroxyprogesterone
Uses of Hydroxyprogesterone
Hydroxyprogesterone is primarily used to reduce the risk of preterm birth in women who are pregnant with a single baby and have a history of spontaneous preterm delivery. It belongs to the group of progestin hormones.
It can be used off-label for managing advanced endometrial cancer, amenorrhea, and abnormal uterine bleeding due to hormonal imbalance, to test for endogenous estrogen production, and to produce secretory endometrium.
Side effects of Hydroxyprogesterone
Pain or swelling at the injection site
Nausea or vomiting
Headaches
Breast tenderness
Changes in weight
How Hydroxyprogesterone works
Hydroxyprogesterone is a synthetic progestin hormone medication.
It functions by imitating the action of naturally occurring progesterone in the body, thus supporting the pregnancy. As a progestin, it prevents premature contractions, which can lead to preterm birth. Progestins essentially act by suppressing the mother's immune response to prevent rejection of the developing embryo. Additionally, they prepare the uterus for successful implantation and development of the embryo.
Certified content
Written By
MD Ayurveda
Reviewed By
Bachelor of Dental Surgery
Expert Advice
Dosage Forms Available
Hydroxyprogesterone can be administered intramuscularly (injection).
Age and Dose Restrictions
This medicine is meant for adult women who are pregnant and have a history of premature birth.
Contraindications
Hydroxyprogesterone is contraindicated in women with a history or current diagnosis of breast cancer or other hormone-sensitive cancers and acute liver disease.
Women with undiagnosed abnormal vaginal bleeding, liver problems or disease, and a history of allergic reactions to Hydroxyprogesterone or any of its components should not take this medicine. It is also contraindicated in cases of missed abortion and patients with a history of blood clots or clotting disorders.
Other Medications to Avoid
Hydroxyprogesterone can potentially interact with enzyme inducers or inhibitors (such as St John's Wort or fluconazole).
Overdose and Missed Dose
Overdose is unlikely since Hydroxyprogesterone is administered by a healthcare professional. If an overdose occurs, supportive and symptomatic treatment should be provided.
For a missed dose, consult your doctor for further guidance. The dose should never be doubled to compensate for the missed one.
Management of Side Effects
Most side effects are temporary and generally harmless, resolving when discontinuing this medicine. However, if you experience any severe side effects or worsening of any symptoms, please consult your doctor.
Drinking plenty of water can help manage common side effects such as nausea, vomiting, and diarrhoea.
Resting and avoiding sudden movements can help manage headaches.
Use in Driving and Operating Machinery
Hydroxyprogesterone may affect your ability to drive or operate machinery. Consult your doctor if you experience these symptoms.
Use in Pregnancy and Lactation
Hydroxyprogesterone is a pregnancy category B medicine. It is used in pregnancy but should be used under the supervision of a doctor.
Small amounts may pass into breast milk but are not expected to be harmful to the nursing baby. Risks and benefits during lactation should be discussed with the prescribing doctor.
Caution in Other Conditions
Patients with a history of blood clots or clotting disorders should exercise caution when taking Hydroxyprogesterone.
Hydroxyprogesterone should also be used with caution in women with conditions that could be affected by fluid retention, such as asthma, migraines, epilepsy, heart disease.
Special Dietary and Lifestyle Recommendations
Regular antenatal check-ups are recommended for monitoring the progress of the pregnancy and early detection of any complications.
Frequently asked questions
Can Hydroxyprogesterone affect mood?
Yes, there can be changes in mood, such as depression or mood swings. If you notice any changes in your mood, consult your doctor immediately.
Does Hydroxyprogesterone influence menstruation?
Hydroxyprogesterone is not typically associated with changes in menstruation as it is usually given to pregnant women to prevent preterm birth.
Is Hydroxyprogesterone available over the counter?
No, Hydroxyprogesterone is not available over the counter. It requires a prescription from your doctor.
Is Hydroxyprogesterone a vegetarian medication?
Yes, Hydroxyprogesterone, being synthetically derived, is suitable for vegetarians. However, if you have specific dietary requirements or allergies, consult your doctor before starting this medicine.
Can Hydroxyprogesterone impact my appetite or cause weight changes?
One of the potential side effects of Hydroxyprogesterone is weight gain or loss. However, not everyone experiences this side effect and it may not be significant.
Is there a natural alternative to Hydroxyprogesterone?
There are no natural alternatives with the same efficacy as Hydroxyprogesterone for preventing preterm birth in women with a history of premature delivery. It is always best to consult your doctor for advice tailored to your specific circumstances.
Can Hydroxyprogesterone be used off-label for other conditions?
Yes, besides its approved use in reducing the risk of preterm birth, Hydroxyprogesterone can also be used off-label for conditions like advanced endometrial cancer, amenorrhea, abnormal uterine bleeding, and other conditions as prescribed by a doctor.
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