Griseofulvin
Uses of Griseofulvin
Griseofulvin is primarily used for the management of dermatophyte fungal infections that have not responded adequately to topical antifungal therapies and falls under the category of antifungal medicines.
This medicine is indicated for managing several types of tinea infections including tinea capitis (scalp ringworm), tinea corporis (body ringworm), tinea pedis (athlete's foot), tinea cruris (jock itch), tinea unguium (onychomycosis, or nail fungus), and tinea barbae (barber's itch).
Side effects of Griseofulvin
Headache
Gastrointestinal distress such as nausea, vomiting, diarrhoea, and abdominal pain
Allergic skin reactions like rashes or urticaria
Dizziness
Fatigue
How Griseofulvin works
Griseofulvin is an antifungal medicine.
It functions by disrupting the process of cell division in fungi. It specifically attaches to a protein called tubulin, which is needed for forming structures called mitotic spindles during cell division. When Griseofulvin binds to tubulin, the proper formation of these spindles is hindered, leading to a halt in cell division. Moreover, Griseofulvin appears to speed up the breakdown of the fungal cell wall. This combined effect of inhibiting cell division and promoting cell wall breakdown makes it effective in managing infections caused by certain types of fungi.
Certified content
Written By
MD Ayurveda
Reviewed By
BMS, FMC, MD Resident
Expert Advice
Dosage Forms Available
Griseofulvin is available as an oral medication (tablets, capsules, and oral suspension).
Age and Dose Restrictions
This medicine is meant for both adults and children. The paediatric dose is based on body weight.
Contraindications
Griseofulvin is contraindicated in patients with known hypersensitivity to it or any of its components. It should not be used by patients suffering from porphyria or severe liver failure.
Other Medications to Avoid
This medication may interact with anticoagulants (such as warfarin), immunosuppressants (like cyclosporine), antiepileptic medication (like phenobarbital), and bronchodilators (like theophylline).
Overdose and Missed Dose
Overdosing on Griseofulvin may lead to symptoms like nausea, vomiting, diarrhoea, headache, dizziness, confusion, and tingling sensation in hands or feet. If you suspect an overdose, immediately contact your doctor.
In case of a missed dose, take it as soon as you remember. However, if it is almost time for the next dose, skip the missed dose and continue your regular dose schedule. Do not double the dose to make up for the missed one.
Management of Side Effects
Most side effects of Griseofulvin are temporary and generally harmless, resolving when you discontinue the medication. However, if you experience any severe side effects or worsening of any symptoms, consult your doctor.
Drinking plenty of fluids may help to manage some side effects like headaches and dizziness.
Taking the medicine after a meal can help to reduce gastrointestinal side effects like nausea and vomiting.
Use in Driving and Operating Machinery
Griseofulvin can cause side effects like dizziness or confusion that may affect your ability to drive or operate heavy machinery. If you experience any of these side effects, avoid activities requiring alertness until you are sure you can perform them safely.
Use in Pregnancy and Lactation
Griseofulvin is not recommended during pregnancy due to its potential for teratogenicity and embryotoxicity. Women of childbearing potential must use effective contraception during and for at least 1 month after completing Griseofulvin therapy.
Caution in Other Conditions
Patients with severe liver disease should use Griseofulvin with caution as it may worsen the condition. Griseofulvin can exacerbate systemic lupus erythematosus, so use caution in patients with this condition.
Special Dietary and Lifestyle Recommendations
Taking Griseofulvin with fatty foods can enhance its absorption.
Practise good personal hygiene to prevent spreading the fungal infection to others.
Avoid sharing personal items like towels, clothing, and combs which can lead to spreading the infection.
Regularly clean and dry affected skin areas thoroughly to prevent the growth of fungi.
Frequently asked questions
Is Griseofulvin a type of steroid?
No, Griseofulvin is not a steroid. It is an antifungal medicine that is primarily used for managing fungal infections of the skin, hair, and nails.
Can Griseofulvin affect sleep patterns?
While Griseofulvin can cause insomnia in some individuals, it does not specifically affect sleep patterns. If you experience difficulties sleeping after taking this medicine, consult your doctor.
Will Griseofulvin have any impact on fertility?
Griseofulvin is not directly associated with affecting human fertility. Women of childbearing potential must use effective contraception during and for at least one month after completing Griseofulvin therapy.
What is the duration of treatment with Griseofulvin?
The duration of treatment with Griseofulvin depends on the nature and severity of the fungal infection. It can range from a few weeks to several months.
Is it safe to take Griseofulvin daily?
Yes, it is safe to take Griseofulvin daily as long as it is prescribed by your doctor. Do not change or stop the dosage without consulting your doctor.
How long does it take for Griseofulvin to start working?
The time it takes for Griseofulvin to work can vary depending on the type of infection and individual response to medication. However, improvements are generally seen within a few days to weeks.
When is the best time to take Griseofulvin?
Griseofulvin should be taken as prescribed by your doctor. It is usually recommended to be taken with meals, particularly fatty ones, as this enhances its absorption.
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