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Granulocyte Colony Stimulating Factor

Uses of Granulocyte Colony Stimulating Factor

  • Granulocyte Colony Stimulating Factor is chiefly used to manage neutropenia (low neutrophil count) caused by chemotherapy, radiation therapy, bone marrow transplant, or severe chronic neutropenia. It belongs to the class of glycoprotein medicines.

  • It is also utilised to mobilise hematopoietic stem cells from the bone marrow into the bloodstream for collection and subsequent autologous or allogeneic stem cell transplantation.

Side effects of Granulocyte Colony Stimulating Factor

  • Bone pain

  • Headache

  • Fatigue

  • Nausea and vomiting

  • Injection site reactions

How Granulocyte Colony Stimulating Factor works

  • Granulocyte Colony Stimulating Factor is a biotechnological medicine. It works by stimulating the bone marrow (a soft tissue inside the bones where blood cells are made) to produce more neutrophils (a type of white blood cell). When it binds to specific receptors on immature neutrophils in the bone marrow, it triggers reactions inside the cell that promote the cell's growth and development into a mature neutrophil.

Certified content

Written By

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Dr. Osama AhmedDental/Medical Writer, Editor, Reviewer|

Bachelor of Dental Surgery

Reviewed By

Dr. Michelle Frank
Dr. Michelle FrankMedical Content Writer| 8 Years

Doctor of Medicine

Expert Advice

Dosage Forms Available

  • Granulocyte Colony Stimulating Factor can be administered subcutaneously or intravenously (injection).

Age and Dose Restrictions

  • This medicine is generally used in adults of age above 18 years.

Contraindications

  • Granulocyte Colony Stimulating Factor is contraindicated in patients with a history of severe allergic reactions to the medicine.

  • It should also not be used in patients with known hypersensitivity to E. coli-derived proteins, as it might trigger allergic reactions.

Other Medications to Avoid

  • Granulocyte Colony Stimulating Factor can interact with antimanic medication (such as lithium).

Overdose and Missed Dose

  • An overdose of Granulocyte Colony Stimulating Factor may result in adverse events such as difficulty breathing, swelling of the face or throat, hives, or skin rash. If you observe these symptoms, inform your doctor immediately.

  • If you forget to administer a dose of this medicine, do it as soon as you remember. But if it is close to the time for your next dose, skip the missed dose and resume your normal dosing schedule.

Management of Side Effects

Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.

  • To manage common side effects like bone pain and headaches, over-the-counter pain relievers (as advised by the doctor) can be used.

  • Ensure you stay well-hydrated to manage symptoms of nausea and vomiting.

Use in Driving and Operating Machinery

  • Granulocyte Colony Stimulating Factor may cause dizziness or fatigue in some patients. If you experience these side effects, avoid driving or operating heavy machinery until you feel confident to do so.

Use in Pregnancy and Lactation

  • It is important to consult your doctor before using this medicine during these periods.

Caution in Other Conditions

  • Patients with pre-existing sickle cell disorders should exercise caution when taking Granulocyte Colony Stimulating Factor as it might trigger a sickle cell crisis.

  • Also, patients with pre-existing myeloid malignancies should be monitored closely while receiving this medicine due to the risk of disease progression.

Special Dietary and Lifestyle Recommendations

  • Maintain a balanced diet rich in fruits, vegetables, lean proteins, and whole grains to support your immune system.

  • Avoid contact with people who are sick or have infections to reduce your risk of catching an infection.

Frequently asked questions

No, Granulocyte Colony Stimulating Factor is not a steroid. It is a type of glycoprotein that stimulates the production and functioning of neutrophils, a type of white blood cell.

Granulocyte Colony Stimulating Factor is not associated with affecting sleep. However, side effects like fatigue can potentially influence your sleep patterns.

Granulocyte Colony Stimulating Factor is not associated with impacting fertility. If you have concerns regarding fertility while using this medication, it is best to consult your doctor.

The half-life of the Granulocyte Colony Stimulating Factor is a few hours, implying that it is eliminated from the body within a few hours after administration.

Granulocyte Colony Stimulating Factor is not directly associated with causing digestive system. However, one of the common side effects can be nausea or vomiting.

Granulocyte Colony Stimulating Factor is not associated with causing mood changes. However, everyone reacts differently to medications, and if you notice any unusual mood changes, consult your doctor.

No known natural substances can replace the function of this medicine in terms of stimulating the production and function of neutrophils.

Terms & Conditions

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