Home/Drugs By Ailments / Folic Acid + Methylcobalamin + Pregabalin + Vitamin B6 / Pyridoxine

Folic Acid + Methylcobalamin + Pregabalin + Vitamin B6 / Pyridoxine

Uses of Folic Acid + Methylcobalamin + Pregabalin + Vitamin B6 / Pyridoxine

  • Folic Acid + Methylcobalamin + Pregabalin + Vitamin B6 / Pyridoxine is primarily used to manage neuropathic pain. It belongs to a class of medications that blend anticonvulsants with vitamins for nerve support.

  • Additionally, this combination may be prescribed for specific neuropathic conditions such as diabetic neuropathy, post-herpetic neuralgia, trigeminal neuralgia, and sciatica.

Side effects of Folic Acid + Methylcobalamin + Pregabalin + Vitamin B6 / Pyridoxine

  • Dizziness

  • Dry mouth

  • Weight gain

  • Edema (swelling)

  • Difficulty concentrating

How Folic Acid + Methylcobalamin + Pregabalin + Vitamin B6 / Pyridoxine works

  • Folic Acid + Methylcobalamin + Pregabalin + Vitamin B6 / Pyridoxine is a combination of nutritional supplements.

  • Pregabalin, as an anticonvulsant, disrupts the transmission of pain signals by lessening the release of neurotransmitters that send out pain signals. This results in significant pain relief.

  • Methylcobalamin, an active form of Vitamin B12, aids in the repair of damaged nerves by supporting the regeneration of myelin, a protective sheath that insulates nerves. It may also have pain-relieving effects by stimulating certain pathways that inhibit pain.

  • Folic Acid plays a significant role in maintaining the health of the nervous system. It aids in the production of serotonin, dopamine, and norepinephrine, neurotransmitters that modulate pain. Thus, Folic Acid might help improve nerve conduction and reduce neuropathic pain.

  • Pyridoxine, commonly known as Vitamin B6, is involved in many metabolic processes. It plays a crucial role in the synthesis of neurotransmitters like serotonin and GABA and offers neuroprotective effects.

Certified content

Written By

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Dr. Michelle FrankMedical Content Writer| 8 Years

Doctor of Medicine

Reviewed By

Dr. Chhavi Rosha
Dr. Chhavi Rosha Health & Medical Content Writer| 8 Years

BMS, FMC, MD Resident

Expert Advice

Dosage Forms Available

  • Folic Acid + Methylcobalamin + Pregabalin + Vitamin B6 / Pyridoxine is available in the form of oral capsules and tablets.

Age and Dose Restrictions

  • This combination is typically prescribed for adults and children over the age of 12 years.

Contraindications

  • This medicine is contraindicated in people with hypersensitivity to any of the ingredients.

  • It is also contraindicated in individuals with end-stage renal disease undergoing haemodialysis.

Other Medications to Avoid

  • This medicine may interact with CNS depressants like benzodiazepines (such as diazepam), opioids (such as morphine) and anticonvulsants (such as phenytoin, phenobarbital and primidone).

Overdose and Missed Dose

  • An overdose of this medication can lead to symptoms such as increased drowsiness, blurred vision, unsteady movement or decreased coordination. If these symptoms occur, consult your doctor immediately.

  • If you miss a dose, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule.

Management of Side Effects

Most side effects will disappear once you stop taking the medicine. However, if any side effect persists or worsens, consult your doctor immediately.

  • For dizziness or drowsiness, try resting and avoid driving or operating machinery until these effects have worn off.

  • If dry mouth occurs, suck on sugarless gum or hard candy.

Use in Driving and Operating Machinery

  • This medication may cause dizziness and drowsiness which can affect your ability to drive or operate heavy machinery. It is advised to avoid such activities if you feel these effects after taking the medication.

Use in Pregnancy and Lactation

  • There is insufficient data on the safety of this medicine during pregnancy and breastfeeding. It is advised to consult your doctor before using this medicine during these periods.

Caution in Other Conditions

  • Individuals with kidney disease should exercise caution when taking this medication, as the medicine is excreted by the kidneys and may accumulate leading to toxicity.

  • People with a history of depression or mood disorders should also be monitored closely as this medication can cause suicidal thoughts and behaviours.

Special Dietary and Lifestyle Recommendations

  • Maintain a healthy diet rich in vitamins, especially B vitamins, to support nerve health.

  • Regular exercise can help manage neuropathic pain.

  • Good sleep hygiene can help manage sleep disturbances associated with neuropathic pain.

Frequently asked questions

Weight gain may occur as a side effect of Pregabalin, one of the components in this combination. If you experience significant weight changes while taking this medicine, it is advisable to consult your doctor.

Pregabalin, an ingredient in this combination, can occasionally cause mood swings or depressive symptoms in some individuals. If you experience these or any other unusual emotional changes while taking this medicine, please consult your doctor immediately.

No. This medicine should not be taken if you have known hypersensitivity or allergic reactions to any of its ingredients.

The duration of therapy varies according to your specific condition and response to treatment. It is crucial to follow your doctor's instructions regarding the duration of treatment.

Generally, this combination requires a prescription from a doctor, as it is used to manage specific medical conditions. It is not usually available over the counter.

No, Folic Acid + Methylcobalamin + Pregabalin + Vitamin B6 / Pyridoxine is not a steroid. It is a combination of vitamins and an anticonvulsant medicine which is used primarily to manage neuropathic pain.

The absorption of pregabalin is not affected by food, so it can be taken with or without food. However, the B-vitamin components are best absorbed with food. To avoid stomach upset, it is preferable to take this medication with food.

Terms & Conditions


Folic Acid + Methylcobalamin + Pregabalin + Vitamin B6 / Pyridoxine in other salts

ALPHA LIPOIC ACID + FOLIC ACID + METHYLCOBALAMIN + VITAMIN B6 (PYRIDOXINE) + VITAMIN D3 (CHOLECALCIFEROL)ALPHA LIPOIC ACID + FOLIC ACID + METHYLCOBALAMIN + VITAMIN B6 / PYRIDOXINEASCORBIC ACID + BIOTIN + CALCIUM PANTOTHENATE + FOLIC ACID + METHYLCOBALAMIN + NIACINAMIDE + RIBOFLAVIN + THIAMINE MONONITRATE + ZINC SULPHATEASCORBIC ACID + ELEMENTAL MANGANESE + ELEMENTAL SELENIUM + ELEMENTAL ZINC + FOLIC ACID + NIACINAMIDE + PYRIDOXINE HYDROCHLORIDE + RIBOFLAVIN / VITAMIN B2 + VITAMIN A + VITAMIN EBIOTIN + CYANOCOBALAMIN / VITAMIN B12 + ELEMENTAL CHROMIUM + ELEMENTAL COPPER + ELEMENTAL MANGANESE + FOLIC ACID + GRAPE SEED EXTRACT + IODINE + MAGNESIUM + RIBOFLAVIN / VITAMIN B2 + SELENIUM + THIAMINE / VITAMIN B1 + VITAMIN A / RETINOL + VITAMIN B3 / NIACIN + VITAMIN B5 / PANTOTHENIC ACID + VITAMIN B6 / PYRIDOXINE + VITAMIN C / ASCORBIC ACID + VITAMIN D3 (CHOLECALCIFEROL) + VITAMIN E + ZINCCALCIUM PHOSPHATE + COPPER SULPHATE PENTAHYDRATE + CYANOCOBALAMIN / VITAMIN B12 + D-PANTHENOL + FOLIC ACID + LIGHT MAGNESIUM OXIDE + NICOTINAMIDE + POTASSIUM IODIDE + VITAMIN A + VITAMIN B1 + VITAMIN B2 + VITAMIN D3 (CHOLECALCIFEROL) + ZINC SULPHATE MONOHYDRATECHROMIUM PICOLINATE + CYANOCOBALAMIN + ELEMENTAL SELENIUM + FOLIC ACID + NICOTINAMIDE + PYRIDOXINE HYDROCHLORIDE + ZINC SULPHATE MONOHYDRATEELEMENTAL CALCIUM + L-METHYLFOLATE CALCIUM + METHYLCOBALAMIN + PYRIDOXAL 5 PHOSPHATE + VITAMIN D3 (CHOLECALCIFEROL)METHYLCOBALAMIN + PREGABALINFERROUS ASCORBATE + FOLIC ACIDFOLIC ACIDRIBOFLAVIN + PYRIDOXINE + VITAMIN B12 + NIACINAMIDE + CALCIUM + FOLIC ACID + BIOTIN + ASCORBIC ACIDMETHYLCOBALAMINPREGABALINL METHYL FOLATE + METHYLCOBALAMIN + PYRIDOXAL 5 PHOSPHATEPREGABALIN + NORTRIPTYLINEPREGABALIN + NORTRIPTYLINE + METHYLCOBALAMINGABAPENTIN + METHYLCOBALAMINBIOTIN + FOLIC ACIDCARBONYL IRON + FOLIC ACID + ZINC SULPHATEL METHYLFOLATE + METHYLCOBALAMIN + PYRIDOXAL 5 PHOSPHATEFOLIC ACID + IRON + ZINCDOCOSAHEXAENOIC ACID + FOLIC ACID + METHYLCOBALAMIN + VITAMIN B6 / PYRIDOXINEALPHA LIPOIC ACID + BENFOTIAMINE + FOLIC ACID + INOSITOL + METHYLCOBALAMIN + VITAMIN B6 (PYRIDOXINE)DULOXETINE + METHYLCOBALAMINALPHA LIPOIC ACID + BENFOTIAMINE + ELEMENTAL CHROMIUM + INOSITOL + METHYLCOBALAMINFOLIC ACID + IRONCYANOCOBALAMIN / VITAMIN B12 + ELEMENTAL IRON + FOLIC ACID + VITAMIN C / ASCORBIC ACID + ZINCDOCOSAHEXAENOIC ACID + FOLIC ACIDDOCOSAHEXAENOIC ACID + L METHYLFOLATE + METHYLCOBALAMIN + PYRIDOXAL 5 PHOSPHATECYANOCOBALAMIN / VITAMIN B12 + ELEMENTAL IRON + ELEMENTAL ZINC + FOLIC ACIDALPHA LIPOIC ACID + METHYLCOBALAMIN + PREGABALINALPHA LIPOIC ACID + GABAPENTIN + METHYLCOBALAMINELEMENTAL IRON + FOLIC ACID + VITAMIN C / ASCORBIC ACIDELEMENTAL IRON + FOLIC ACID + GLYCINEALPHA LIPOIC ACID + FOLIC ACID + METHYLCOBALAMIN + THIAMINE MONONITRATE + VITAMIN B6 / PYRIDOXINEALPHA LIPOIC ACID + METHYLCOBALAMINALPHA LIPOIC ACID + FOLIC ACID + METHYLCOBALAMIN + VITAMIN B6 (PYRIDOXINE)ALPHA LIPOIC ACID + CYANOCOBALAMIN / VITAMIN B12 + FOLIC ACID + VITAMIN B6 (PYRIDOXINE)ALPHA LIPOIC ACID + BENFOTIAMINE + BIOTIN + ELEMENTAL CHROMIUM + FOLIC ACID + METHYLCOBALAMIN + VITAMIN B6 / PYRIDOXINEALPHA LIPOIC ACID + CHROMIUM PICOLINATE + FOLIC ACID + INOSITOL + METHYLCOBALAMIN + SELENOMETHIONINE + ZINC MONOMETHIONINEELEMENTAL IRON + FOLIC ACIDCYANOCOBALAMIN / VITAMIN B12 + PREGABALINALPHA LIPOIC ACID + BENFOTIAMINE + FOLIC ACID + INOSITOL + METHYLCOBALAMIN + VITAMIN B6 / PYRIDOXINEFOLIC ACID + METHYLCOBALAMIN + VITAMIN B6 / PYRIDOXINE + VITAMIN D3 (CHOLECALCIFEROL)BIOTIN + CALCIUM PANTOTHENATE + CYANOCOBALAMIN / VITAMIN B12 + FOLIC ACID + NIACINAMIDE + RIBOFLAVIN / VITAMIN B2 + THIAMINE / VITAMIN B1 + VITAMIN B6 / PYRIDOXINE + VITAMIN C / ASCORBIC ACIDELEMENTAL IRON + ELEMENTAL ZINC + FOLIC ACIDFERROUS FUMARATE + FOLIC ACIDALPHA LIPOIC ACID + BENFOTIAMINE + BIOTIN + CHROMIUM PICOLINATE + FOLIC ACID + METHYLCOBALAMIN + VITAMIN B6 (PYRIDOXINE)ALPHA LIPOIC ACID + FOLIC ACID + METHYLCOBALAMIN + PREGABALIN + VITAMIN B6 (PYRIDOXINE)CYANOCOBALAMIN / VITAMIN B12 + ELEMENTAL IRON + FOLIC ACID + VITAMIN C / ASCORBIC ACIDELEMENTAL IRON + ELEMENTAL ZINC + FOLIC ACID + METHYLCOBALAMINBORON + CALCITRIOL/ CHOLECALCIFEROL + CALCIUM CARBONATE + DHA / DOCOSAHEXAENOIC ACID + EPA / EICOSAPENTAENOIC ACID + FOLIC ACID + METHYLCOBALAMINVITAMIN B6 / PYRIDOXINEBENFOTIAMINE + FOLIC ACID + METHYLCOBALAMIN + PREGABALIN + VITAMIN B6 (PYRIDOXINE)AMITRIPTYLINE + PREGABALINCALCITRIOL/ CHOLECALCIFEROL + CALCIUM CARBONATE + L METHYLFOLATE + MAGNESIUM + METHYLCOBALAMIN + VITAMIN K27 + ZINCALPHA LIPOIC ACID + FOLIC ACID + METHYLCOBALAMIN + PYRIDOXINE HYDROCHLORIDE + VITAMIN D3 (CHOLECALCIFEROL)FERROUS ASCORBATE + FOLIC ACID + ZINC SULPHATECYANOCOBALAMIN / VITAMIN B12 + FOLIC ACID + NICOTINAMIDECYANOCOBALAMIN / VITAMIN B12 + FERRIC AMMONIUM CITRATE + FOLIC ACIDCAPSAICIN + DICLOFENAC DIETHYLAMINE + MENTHOL + METHYL SALICYLATE + PREGABALINMETHYLCOBALAMIN + NICOTINAMIDE + VITAMIN B6 / PYRIDOXINED-PANTHENOL + METHYLCOBALAMIN + NIACINAMIDE + VITAMIN B6 / PYRIDOXINEFOLIC ACID + METHYLCOBALAMIN + NIACINAMIDEMETHYLCOBALAMIN + NIACINAMIDE + VITAMIN B6 / PYRIDOXINECYANOCOBALAMIN / VITAMIN B12 + D-PANTHENOL + NIACINAMIDE + RIBOFLAVIN / VITAMIN B2 + THIAMINE / VITAMIN B1 + VITAMIN B6 / PYRIDOXINEFOLIC ACID + METHYLCOBALAMIN + NIACINAMIDE + VITAMIN B6 / PYRIDOXINEMETHYLCOBALAMIN + NICOTINAMIDE + VITAMIN B6 (PYRIDOXINE)D-PANTHENOL + METHYLCOBALAMIN + NIACINAMIDE + VITAMIN B6 (PYRIDOXINE)MAGNESIUM CITRATE + POTASSIUM CITRATE + VITAMIN B6 / PYRIDOXINECYANOCOBALAMIN + ELEMENTAL IRON + ELEMENTAL ZINC + FOLIC ACIDCYANOCOBALAMIN + ELEMENTAL IRON + FOLIC ACIDCYANOCOBALAMIN / VITAMIN B12 + L-LYSINE + NIACINAMIDE + VITAMIN B6 / PYRIDOXINEFERROUS ASCORBATE + FOLIC ACID + METHYLCOBALAMINDOXYLAMINE + VITAMIN B6 / PYRIDOXINEACECLOFENAC + PREGABALINEPALRESTAT + METHYLCOBALAMINEPALRESTAT + PREGABALINAMITRIPTYLINE + METHYLCOBALAMINDOXYLAMINE + FOLIC ACID + VITAMIN B6 / PYRIDOXINEFOLIC ACID + L-CARNITINE / LEVOCARNITINE + METHYLCOBALAMINMETFORMIN + METHYLCOBALAMINCALCIUM-5 METHYLTETRAHYDROFOLATE + METHYLCOBALAMIN + PYRIDOXAL 5 PHOSPHATEELEMENTAL CALCIUM + FOLIC ACID + VITAMIN D3 (CHOLECALCIFEROL)D CHIRO INOSITOL + L-METHYLFOLATE + METFORMIN + METHYLCOBALAMIN + MYO INOSITOLN-ACETYLCYSTEINE + VITAMIN B6 / PYRIDOXINEFERROUS ASCORBATE + FOLIC ACID + ZINC SULPHATE MONOHYDRATEFOLIC ACID + LACTIC ACID BACILLUS + NIACINAMIDE + RIBOFLAVIN / VITAMIN B2CYANOCOBALAMIN / VITAMIN B12 + NORTRIPTYLINE + PREGABALINCALCIUM CITRATE + FOLIC ACID + VITAMIN D3 (CHOLECALCIFEROL)ACETYLCYSTEINE + VITAMIN B6 / PYRIDOXINEETORICOXIB + PREGABALINDIACEREIN + GLUCOSAMINE SULFATE POTASSIUM CHLORIDE + METHYL SULFONYL METHANE + METHYLCOBALAMINDOXYLAMINE + FOLIC ACID + VITAMIN B6 (PYRIDOXINE)ALPHA LIPOIC ACID + BENFOTIAMINE + CALCIUM CARBONATE + CHROMIUM PICOLINATE + FOLIC ACID + INOSITOL + METHYLCOBALAMIN + PYRIDOXINE HYDROCHLORIDE + VITAMIN D3 (CHOLECALCIFEROL)
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