Erlotinib
Uses of Erlotinib
Erlotinib is primarily used to manage certain types of non-small cell lung cancer (NSCLC) and pancreatic cancer. It belongs to the kinase inhibitors class of medications.
It can be used as a first-line treatment, maintenance therapy, or second- or later-line treatment for NSCLC with specific EGFR mutations. It is also used in combination with gemcitabine for the first-line management of patients with locally advanced, unresectable, or metastatic pancreatic cancer.
Side effects of Erlotinib
Rash
Diarrhoea
Fatigue
Loss of appetite
Cough
How Erlotinib works
Erlotinib is a kinase inhibitor.
It functions by blocking the activity of a protein called epidermal growth factor receptor tyrosine kinase, often found in excess in some cancer cells. By doing this, it prevents the growth and spread of these cancer cells, managing their progression.
Certified content
Written By
BDS, MDS
Reviewed By
BMS, FMC, MD Resident
Expert Advice
Dosage Forms Available
Erlotinib is available as a tablet for oral administration.
Age and Dose Restrictions
Erlotinib is meant for adult use only.
Its dosage and duration are to be decided by your doctor. Follow the doctor's instructions closely.
Contraindications
Erlotinib does not have any known contraindications based on medical conditions.
Other Medications to Avoid
Erlotinib can interact with strong inhibitors of CYP3A4 (such as ketoconazole, itraconazole, voriconazole, and clarithromycin) and strong inducers of CYP3A4 (such as rifampin, phenytoin, and carbamazepine).
Consult your doctor before starting any new medication while taking this medicine.
Overdose and Missed Dose
An overdose may lead to side effects such as mouth sores and nausea. If such symptoms persist or worsen, inform your doctor immediately.
If you miss a dose, take it as soon as you remember and consult your doctor for dosage instructions. Do not double the dose to compensate for a missed one.
Management of Side Effects
Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience severe side effects or worsening symptoms, consult your doctor.
Drinking ample water can help manage diarrhoea and mouth sores.
Eating smaller meals more frequently can help manage appetite loss and nausea.
Use in Driving and Operating Machinery
Erlotinib may cause fatigue and affect your ability to drive or operate heavy machinery. If you feel drowsy or fatigued after taking this medicine, refrain from doing these activities.
Use in Pregnancy and Lactation
Erlotinib should not be used during pregnancy or while breastfeeding, as it may harm the foetus or infant. If you are pregnant, planning to become pregnant, or breastfeeding, consult your doctor before starting this medicine.
Caution in Other Conditions
Patients with pre-existing liver disease, hepatic impairment, or biliary tract disease should exercise caution and be closely monitored by a doctor when starting Erlotinib.
Special Dietary and Lifestyle Recommendations
Patients should avoid grapefruit and grapefruit juice while on Erlotinib as these can increase the risk of its side effects.
Patients taking it are advised to limit sun exposure and use sunscreen due to an increased risk of skin reactions.
Patients are recommended to quit smoking as it can reduce the medicine's effectiveness.
Frequently asked questions
Is Erlotinib a steroid?
No, Erlotinib is not a steroid. It is a kinase inhibitor.
Does Erlotinib affect sleep?
No specific effect of Erlotinib on sleep is mentioned in the medical literature. However, if you experience related problems when using this medicine, please consult your doctor.
Will Erlotinib affect fertility?
There is no specific information on its impact on fertility. If this is a concern for you, please consult your doctor before starting this treatment.
Can Erlotinib be taken on a full stomach?
It should be taken on an empty stomach to enhance absorption and avoid interaction with specific foods.
Is it safe to take Erlotinib daily?
Yes, it is safe to take daily, if recommended by your doctor. Do not alter or stop your dosage without consulting them.
How much time does Erlotinib take to work?
The time to show effect varies from person to person and could range from weeks to several months, depending on individual response.
What is the best time to take Erlotinib?
Erlotinib should be taken at least one hour before or two hours after a meal. The exact time and dosage can be decided upon consultation with your doctor.
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