Epirubicin
Uses of Epirubicin
Epirubicin is primarily used for managing various types of cancers, including breast cancer, ovarian cancer, gastric cancer, lung cancer and lymphoma. It belongs to the class of anthracycline anti-cancer medications.
Side effects of Epirubicin
Hair loss
Nausea and vomiting
Inflammation of mucous membranes
Increased liver enzymes
How Epirubicin works
Epirubicin is an anthracycline class of anti-cancer medication.
It works by inserting itself between the DNA's base pairs, which prevents supercoiled DNA from relaxing and interferes with DNA replication, transcription, and repair processes.
Certified content
Written By
Doctor of Medicine
Reviewed By
BMS, FMC, MD Resident
Expert Advice
Dosage Forms Available
Epirubicin is available for administration via the intravenous route (injection).
Age and Dose Restrictions
This medicine is meant for adults only. It is not recommended for use in children or adolescents under 18 years of age.
Contraindications
Epirubicin is contraindicated in patients with a known hypersensitivity to epirubicin, other anthracyclines, or any component of the formulation.
It is also contraindicated in patients with severe liver impairment, recent myocardial infarction or severe arrhythmias and in those who have received maximum cumulative doses of anthracyclines.
Other Medications to Avoid
Epirubicin can interact with myelosuppressive medications (such as cisplatin and carboplatin), cardiotoxic medicines (such as trastuzumab), and antifungal medicines (such as ketoconazole).
Overdose and Missed Dose
An overdose of Epirubicin may cause severe myelosuppression, cardiotoxicity and severe gastrointestinal toxicity. If you observe these symptoms, inform your doctor immediately.
If you miss a dose of this medicine, contact your doctor for further guidance. Do not administer a double dose to make up for the missed dose.
Management of Side Effects
Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening symptoms, please consult your doctor.
To manage nausea and vomiting, eat small, frequent meals instead of large ones and drink plenty of fluids.
For mouth sores, maintain good oral hygiene by brushing twice daily and using a soft toothbrush.
Use in Driving and Operating Machinery
Epirubicin may cause nausea, vomiting, and general weakness, affecting your ability to drive or operate machinery. Avoid such activities if you feel unwell after the administration of this medicine.
Use in Pregnancy and Lactation
Epirubicin may have harmful effects on a foetus. Therefore, it is not recommended for use during pregnancy unless necessary.
Epirubicin is excreted into breast milk and may harm a nursing baby. Thus, breastfeeding should be discontinued during treatment with this medicine.
Caution in Other Conditions
Patients with pre-existing heart conditions and liver impairment should exercise caution when taking Epirubicin.
Regular monitoring of blood cell counts, liver function tests and cardiac function is advised during treatment with this medication.
Special Dietary and Lifestyle Recommendations
Stay hydrated by drinking plenty of fluids, especially if experiencing vomiting or diarrhoea.
Regular meditation or other relaxation techniques could help manage stress related to the condition and its treatment.
Frequently asked questions
Is Epirubicin a steroid?
No, Epirubicin is not a steroid. It is an anthracycline class anti-cancer medication.
Does Epirubicin have any effect on sleep?
Epirubicin is not commonly associated with affecting sleep. However, the emotional stress of dealing with cancer and its treatment can potentially disrupt sleep. Always share any sleep problems with the doctor.
Will Epirubicin affect fertility?
Yes, Epirubicin may affect fertility in men and women. Women may experience amenorrhea or absence of menstruation, which can affect their ability to become pregnant. Men may have changes in sperm production.
Is it safe to administer Epirubicin daily?
Epirubicin is not intended to be administered daily. It is usually administered via intravenous infusion every 3-4 weeks, depending on the type of cancer and severity of the condition.
How much time does Epirubicin take to work?
The time taken by Epirubicin to show its effects may vary depending on the type of cancer and individual patient characteristics.
What is the best time to administer Epirubicin?
Epirubicin is administered in a healthcare setting, and the timing is usually determined by the doctor based on your cancer treatment schedule.
What is the duration of treatment with Epirubicin?
The duration of treatment with Epirubicin depends on the type of cancer, response to treatment, and patient's overall health condition. Your doctor will decide the duration of treatment with Epirubicin, depending on the above factors.
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