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Disodium Hydrogen Citrate

URINARY ALKALISER

Uses of Disodium Hydrogen Citrate

  • Disodium hydrogen citrate is used to increase the alkalinity of urine in various conditions, including pyelitis, cystitis, urethritis, and urolithiasis. 
  • It is also used when treating urinary tract infections when antibiotics, such as sulphonamides and fluoroquinolones, exhibit enhanced efficacy under alkaline pH conditions. Additionally, it can counteract the tendency towards acute or chronic metabolic acidosis during acute infections and dehydration.
  • It is also used  in the treatment of gout and kidney stones.

Side effects of Disodium Hydrogen Citrate

The side effects of Disodium Hydrogen Citrate are:

  • Mood changes
  • Tiredness
  • Muscle weakness
  • Shortness of breath
  • Nausea
  • Vomiting

How Disodium Hydrogen Citrate works

  • Disodium hydrogen citrate is a urinary alkaliser. 
  • It undergoes metabolism to bicarbonate, leading to an elevation in the excretion of free bicarbonate ions. This mechanism contributes to the elevation of urinary pH, resulting in a reduction of urine acidity.
  • By reducing urine acidity, it helps the kidneys remove excess uric acid, preventing gout and certain types of kidney stones.  Moreover, the use of disodium hydrogen citrate may also help in urinary tract infections.

Certified content

Written By

docImg
Amit SharmaClinical Health & Medical Writer| 3 Years

B. Pharm

Reviewed By

Amatul Ameen
Amatul Ameen Clinical Health & Medical Writer| 12 Years

B. Pharm, MSc.

Expert Advice

Dosage Forms Available for Disodium Hydrogen Citrate

  • Disodium hydrogen citrate is available for use via the oral route (syrup).

Age And Dosage Restrictions for Disodium Hydrogen Citrate

  • This medicine is meant for adults and children above 6 years of age.

Contraindications of Disodium Hydrogen Citrate

  • Disodium hydrogen citrate is contraindicated in patients with severe renal impairment accompanied by oliguria (reduced urinary output), azotemia (a condition of high nitrogen and waste products in the blood), anuria (lack of urine production), untreated Addison’s disease, acute dehydration, heat cramps, or severe damage to the heart following a heart attack. Additionally, sodium salts are not recommended for patients following a sodium-restricted diet.

Medications To Avoid With Disodium Hydrogen Citrate

  • It is not advised to administer aluminium antacids and citrate salts concurrently, particularly in patients with renal insufficiency. Anti-diabetic medicines like chlorpropamide, medicines used for the management of bipolar disorder like lithium, anti-cancer medicines like methotrexate, antibiotics like tetracyclines and methenamine, pain-relieving medicines like salicylates should be used with caution along with disodium hydrogen citrate.

Overdose and Missed Dose

  • Overdose of this medication may cause symptoms like diarrhoea, nausea, vomiting, hypernoia (excessive mental activity), fluid accumulation and swelling and convulsions. If you observe these symptoms, inform your doctor and follow the advice accordingly.
  • If you forget to take this medicine, take it as soon as you remember. But avoid repeating the dose.

Management of Side Effects

  • Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.

Use In Driving And Operating Machinery

  • This medication will not affect your driving or ability to handle heavy machinery.

Use in Pregnancy and Lactation

  • The use of this medication during pregnancy or while breastfeeding should be done only if recommended by the doctor.

Caution In Other Conditions

  • When using disodium hydrogen citrate, caution should be exercised in patients with conditions involving sodium retention, such as oedema, congestive heart failure, hypertension, pulmonary or peripheral oedema, or toxaemia of pregnancy. Monitoring serum electrolytes, especially serum bicarbonate levels, is recommended for patients with renal disease. Patients with low urinary output or reduced glomerular filtration rates should be treated cautiously. Additionally, caution is advised when administering blood products containing citrate to patients with acute liver failure.

Special Dietary & Lifestyle Recommendation

  • Staying hydrated by consuming ample fluids, which aid in eliminating surplus minerals, is recommended to promote kidney health. 
  • Restricting salt intake is advisable, as excessive salt can increase the chances of kidney stones. Additionally, maintaining an average weight through regular exercise is beneficial. 
  • Avoiding foods high in oxalates, like spinach, nuts, okra, dates, avocado, hot chocolate, cocoa, baked potatoes, French fries, and certain cereals, is also advised, as they may elevate the risk of oxalate stone formation.

Frequently asked questions

This medicine's onset of action may require a few weeks for full efficacy to be realised.

Patients with low urinary output or reduced glomerular filtration rates should be treated cautiously. Additionally, caution is advised when administering blood products containing citrate to patients with acute liver failure.

Please refrain from discontinuing disodium hydrogen citrate without consulting your doctor first. Abruptly stopping the medication may result in the return of symptoms.

Disodium hydrogen citrate is not recommended in patients with kidney issues, while caution is advised for those with liver issues. 

It is unlikely that it would impact fertility in men or women. For the most accurate information, it is advisable to consult your doctor.

Consult your doctor before taking corticosteroids with Disodium Hydrogen Citrate, as the combination may increase blood sodium levels.

If you are on a sodium-restricted diet, you should consult your doctor before taking Disodium Hydrogen Citrate. This medication contains sodium, which might not be suitable for your diet and could affect your health condition.

Yes, Disodium Hydrogen Citrate can cause diarrhoea as a side effect. If you experience severe or persistent diarrhoea, it is important to contact your healthcare provider for advice.

Terms & Conditions

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