Desvenlafaxine
Uses of Desvenlafaxine
The primary use of Desvenlafaxine is for the management of major depressive disorder (MDD) in adults. It belongs to a class of medications known as serotonin-norepinephrine reuptake inhibitors (SNRIs).
In addition to this, Desvenlafaxine may also be used off-label for managing other conditions such as generalized anxiety disorder, social anxiety disorder, and vasomotor symptoms associated with menopause.
Side effects of Desvenlafaxine
Nausea
Dizziness
Insomnia
Constipation
Fatigue
How Desvenlafaxine works
Desvenlafaxine is a type of antidepressant known as a serotonin-norepinephrine reuptake inhibitor (SNRI).
Its primary function is to inhibit the reuptake of two neurotransmitters, namely serotonin and norepinephrine, found in the brain. Neurotransmitters are chemicals that transmit signals from one nerve cell to another. By inhibiting reuptake, Desvenlafaxine increases the levels of these neurotransmitters in the brain. This allows more serotonin and norepinephrine to be available for transmission of signals, thus helping to restore chemical balance in the brain. This increase in neurotransmitter levels can lead to an improvement in mood and a reduction in the symptoms of depression.
Certified content
Written By
Doctor of Medicine
Reviewed By
BMS, FMC, MD Resident
Expert Advice
Dosage Forms Available
Desvenlafaxine is available for oral administration in the form of extended-release tablets.
Age and Dose Restrictions
This medication is meant for adults.
Contraindications
Desvenlafaxine is contraindicated in patients with known hypersensitivity to desvenlafaxine, venlafaxine, or any of the inactive ingredients. Patients taking Monoamine Oxidase Inhibitors (MAOIs) or within 14 days of stopping such treatment should not use this medicine.
Other Medications to Avoid
Desvenlafaxine may interact with Monoamine Oxidase Inhibitors (such as selegiline, and phenelzine), anticoagulants (such as warfarin), and NSAIDs (like ibuprofen, and naproxen).
Overdose and Missed Dose
Overdosing on Desvenlafaxine may result in severe nausea, vomiting, dizziness, seizures, or changes in heart rate. In case of an overdose, seek medical attention immediately.
If you miss a dose of Desvenlafaxine, take it as soon as you remember. However, if it is close to the time for your next dose, skip the missed dose. Do not double up on doses.
Management of Side Effects
Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.
Drinking plenty of water may help manage side effects such as dry mouth and constipation.
Taking this medication with food may help reduce nausea.
Use in Driving and Operating Machinery
Desvenlafaxine may cause dizziness or sleepiness. Avoid driving or operating heavy machinery if you experience these side effects.
Use in Pregnancy and Lactation
Desvenlafaxine should be used during pregnancy only if the potential benefits outweigh the potential risks to the fetus. This medication is excreted in human milk, so caution should be exercised when administering it to a nursing woman.
Caution in Other Conditions
Patients with high blood pressure, a history of seizures, or those at risk for angle-closure glaucoma should exercise caution when taking this medicine. Patients with renal or hepatic impairment should also use this medicine with caution.
Special Dietary and Lifestyle Recommendations
Maintain a balanced diet and regular physical activity to support overall mental health.
Try to incorporate relaxation techniques such as deep breathing, yoga, or mindfulness meditation into your daily routine to help manage stress and improve mood.
Ensure a regular sleep schedule to help manage insomnia that may be associated with depression.
Avoid alcohol and caffeine as they may worsen anxiety and trigger panic attacks, making depression symptoms more severe.
Frequently asked questions
Does Desvenlafaxine have any effect on sleep?
Yes, one of the common side effects of Desvenlafaxine can be insomnia, which refers to difficulty in falling asleep or maintaining sleep.
Will Desvenlafaxine affect fertility?
There is no clear-cut evidence to suggest that Desvenlafaxine significantly affects fertility. However, if you have any concerns regarding this, it is best to consult your doctor.
Is it safe to take Desvenlafaxine daily?
Yes, it is safe to take Desvenlafaxine daily, as long as it is taken as per the dosage and duration recommended by the doctor.
How much time does Desvenlafaxine take to work?
The time taken for Desvenlafaxine to start showing its effects may vary from person to person. However, most people begin to notice an improvement in their symptoms within 1-2 weeks of starting the medication.
What is the best time to take Desvenlafaxine?
Desvenlafaxine can be taken either in the morning or evening, with or without food. The best time would be the one that helps you remember to take it regularly and consistently.
How long does Desvenlafaxine stay in the body?
The precise duration that Desvenlafaxine stays in the body can vary depending on several factors, including dosage, metabolism, and individual health conditions. This is a complex question best answered by your doctor or pharmacist.
Is Desvenlafaxine available over the counter, or do I need a prescription?
No, Desvenlafaxine is not available over the counter and requires a doctor's prescription.
Desvenlafaxine in other salts
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