Dasatinib
Uses of Dasatinib
Dasatinib is primarily used for the management of certain types of leukemia, such as Philadelphia chromosome-positive (Ph+) chronic myeloid leukemia (CML), and belongs to the group of tyrosine kinase inhibitors.
For adults, it is also indicated in cases of chronic, accelerated, or myeloid or lymphoid blast phase Ph+ CML with resistance or intolerance to prior therapy, including imatinib, as well as Ph+ acute lymphoblastic leukaemia (ALL) with resistance or intolerance to prior therapy.
Side effects of Dasatinib
Decreased blood cell counts
Fluid retention
Diarrhoea, nausea, vomiting
Skin rash
Musculoskeletal pain
How Dasatinib works
Dasatinib is a tyrosine kinase inhibitor.
It operates by hindering the function of multiple tyrosine kinases, enzymes that stimulate cancer cell growth. Its chief target is the abnormal BCR-ABL tyrosine kinase produced due to the Philadelphia chromosome abnormality. By obstructing these proteins, Dasatinib manages to slow or halt the growth and proliferation of leukaemia cells in the body.
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Expert Advice
Dosage Forms Available
Dasatinib can be taken orally (tablet).
Age and Dose Restrictions
This medicine is meant for adults and children aged 1 year and older.
Contraindications
This medicine is contraindicated in patients with known hypersensitivity to Dasatinib. It should be used cautiously in patients with a history of heart problems, risk factors for pulmonary hypertension, a history of bleeding or liver problems, or long QT syndrome.
Other Medications to Avoid
Dasatinib can interact with strong Antacids (e.g., aluminium hydroxide, magnesium hydroxide).
Overdose and Missed Dose
An overdose of Dasatinib primarily results in severe myelosuppression that causes fatigue, increased infection risk, easy bruising, bleeding, and shortness of breath. If you observe this symptom, inform your doctor immediately.
If you forget to take this medicine, take it as soon as you remember. However, if it's close to the time for your next dose, skip the missed dose.
Management of Side Effects
Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.
If you experience fluid retention, reduce your salt intake.
To manage nausea and vomiting, try taking Dasatinib with food.
If you experience diarrhoea, drink plenty of water to stay hydrated.
Use in Driving and Operating Machinery
Dasatinib may affect your ability to drive or operate heavy machinery due to its potential side effects such as dizziness and fatigue. If you feel dizzy after taking this medication, avoid driving or operating heavy machinery until these symptoms pass.
Use in Pregnancy and Lactation
Dasatinib should be used in pregnancy only if the potential benefit justifies the potential risk to the fetus. Breastfeeding is not recommended during treatment with this medicine.
Caution in Other Conditions
Patients with kidney or liver impairment do not require dosage adjustments when taking Dasatinib. However, caution should be exercised when administering this medication to these patients due to the potential risk of increased side effects.
Special Dietary and Lifestyle Recommendations
Make sure to drink plenty of fluids to stay hydrated, especially if you experience diarrhoea or vomiting.
Practise good hygiene to reduce your risk of infection while taking Dasatinib.
Frequently asked questions
Does Dasatinib have any effects on mood?
There is no specific information that suggests Dasatinib has any direct effects on mood. However, if you observe any mood changes while taking this medicine, you should consult with your doctor.
Can Dasatinib cause weight gain?
While Dasatinib can cause fluid retention, it does not directly lead to weight gain. If you notice an unusual increase in your weight while on this medication, please talk to your doctor.
Does Dasatinib affect menstruation?
There is no specific information suggesting that Dasatinib affects menstruation. However, if you experience any changes in your menstrual cycle while on this medication, consult your doctor immediately.
How long does Dasatinib stay in the system?
Dasatinib has an elimination half-life of 3 to 5 hours, which means it takes 3 to 5 hours for its concentration in the body to be reduced by half. However, it usually takes around 5 to 6 half-lives for a medicine to be mostly eliminated from your system.
Is Dasatinib a steroid?
No, Dasatinib is not a steroid. It is a medicine that belongs to the class of medicines known as tyrosine kinase inhibitors.
Does Dasatinib have any effect on sleep?
Some side effects of Dasatinib like fatigue might indirectly affect sleep patterns.
Is Dasatinib available over the counter, or do I need a prescription?
Dasatinib is a prescription-only medicine and is not available over the counter.
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