Darifenacin
Uses of Darifenacin
Darifenacin is used to manage symptoms of overactive bladder in adults. It belongs to a class of medicines called antimuscarinics or anticholinergics.
Side effects of Darifenacin
Dry mouth
Constipation
Blurred vision
Dizziness
Nausea
How Darifenacin works
Darifenacin is an antimuscarinic or anticholinergic medicine.
It operates by blocking the action of acetylcholine, a chemical messenger, on muscarinic receptors in the bladder. Acetylcholine, when active, causes the bladder muscles to contract.
Certified content
Written By
BDS, MDS
Reviewed By
BAMS, APG, PG
Expert Advice
Dosage Forms Available
Darifenacin can be taken orally (tablet).
Age and Dose Restrictions
Darifenacin is intended for use by adults aged 18 and above.
Contraindications
Darifenacin is contraindicated in patients with urinary retention, gastric retention, and uncontrolled narrow-angle glaucoma.
It should also not be used by patients who are known to have hypersensitivity to darifenacin or any of its components.
Other Medications to Avoid
Darifenacin may interact with potent inhibitors of CYP3A4 (e.g., ketoconazole, itraconazole, ritonavir, and clarithromycin), antihistamines (e.g., cetirizine), tricyclic antidepressants (e.g., doxepin), and certain antipsychotics (e.g., iloperidone).
Overdose and Missed Dose
Overdosing on Darifenacin may lead to severe anticholinergic effects such as severe dry mouth, constipation, blurred vision, and urinary retention. If you suspect an overdose, seek immediate medical attention.
If a dose is missed, take it as soon as you remember unless it is almost time for your next dose. In this case, skip the missed dose and continue with your regular dosing schedule. Do not double up on doses to make up for a missed one.
Management of Side Effects
Most side effects tend to lessen or disappear with continued use of Darifenacin. However, if they persist or worsen, consult your doctor immediately.
Drinking plenty of water can help manage dry mouth.
Regularly changing positions can help reduce dizziness or feeling faint when rising from a sitting or lying position.
Use in Driving and Operating Machinery
Darifenacin may cause dizziness, drowsiness, or blurred vision which may affect your ability to drive or operate heavy machinery. Avoid these activities until you know how this medication affects you.
Use in Pregnancy and Lactation
The safety of Darifenacin use during pregnancy and while breastfeeding has not been established. Therefore, it is advised to consult your doctor if you are pregnant, planning to become pregnant, or breastfeeding.
Caution in Other Conditions
Patients with clinically significant bladder outlet obstruction, gastrointestinal obstructive disorders, controlled narrow-angle glaucoma, moderate hepatic impairment, or myasthenia gravis should exercise caution when taking Darifenacin.
Special Dietary and Lifestyle Recommendations
Stay hydrated: Ensure that you drink adequate fluids daily to prevent constipation and dehydration.
Frequently asked questions
Is Darifenacin a steroid?
No, Darifenacin is not a steroid. It is an antimuscarinic or anticholinergic medication used primarily for managing symptoms of overactive bladder in adults.
Does Darifenacin have any effect on sleep?
Darifenacin may cause drowsiness or sleepiness in some patients. However, it is not specifically designed to induce sleep or affect sleep patterns. If you experience excessive sleepiness after taking this medicine, consult your doctor.
Will Darifenacin affect fertility?
Darifenacin is not known to affect fertility directly. If you have concerns about fertility, it is advisable to discuss this with your doctor before starting this medication.
Does Darifenacin affect mood or behaviour?
Darifenacin can cause central nervous system effects, which may include changes in mood or behaviour, such as confusion or hallucinations. These effects are more common in elderly patients with dementia.
What is the best time to take Darifenacin?
Darifenacin can be taken at any time of the day that suits you, with or without food. However, it is always recommended to follow your doctor's instructions about the best time to take your medication.
What is the duration of treatment with Darifenacin?
The duration of treatment with Darifenacin would depend on the individual's response to the medication and the severity of symptoms. Always follow the duration recommended by your doctor.
Is Darifenacin available over the counter, or do I need a prescription?
Darifenacin is a prescription medicine and is not readily available over the counter. It should be taken under medical supervision.
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