Daclatasvir
Uses of Daclatasvir
Daclatasvir is primarily used in managing chronic hepatitis C virus (HCV) infection in adults and is part of the class of medicines known as HCV NS5A inhibitors.
It is indicated for the treatment of chronic HCV genotype 1, 3, or 4 infection in adults. However, its effectiveness can be reduced in patients with cirrhosis.
Side effects of Daclatasvir
Headache
Fatigue
Nausea
Diarrhoea
Insomnia
How Daclatasvir works
Daclatasvir is categorised as an antiviral medication.
It functions by restraining the action of a vital protein known as nonstructural protein 5A (NS5A). This protein is required by the hepatitis C virus (HCV) for its replication. By obstructing the NS5A protein, Daclatasvir significantly reduces HCV's amount in the body, thereby slowing down the progression of liver disease caused by this chronic infection.
Certified content
Written By
MSc (Applied Genetics)
Reviewed By
BMS, FMC, MD Resident
Expert Advice
Dosage Forms Available
Daclatasvir can be taken orally (tablet).
Age and Dose Restrictions
Daclatasvir is meant for adults who are 18 years old and older.
Contraindications
Daclatasvir is contraindicated in patients who are taking strong inducers of CYP3A (such as rifampin, phenytoin, carbamazepine). This medicine is also contraindicated in patients who have a known hypersensitivity to Daclatasvir or any of its components.
Other Medications to Avoid
Daclatasvir may interact with certain medications such as antifungals (like ketoconazole and itraconazole), moderate inducers of CYP3A (like modafinil, efavirenz), and certain antibiotics (such as rifampin and nafcillin).
Overdose and Missed Dose
Overdosing on Daclatasvir can lead to side effects like headache, fatigue, and nausea intensifying. If you suspect an overdose, seek medical help immediately.
If you miss a dose of Daclatasvir, take it as soon as you remember. However, if it is close to the time for your next dose, skip the missed dose. Do not double up on doses to compensate for the missed one.
Management of Side Effects
Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.
To manage the common side effects of nausea, try taking Daclatasvir with food.
If you experience headaches, rest and hydration may help.
Fatigue can be managed by pacing your activities and ensuring adequate rest and sleep.
If you experience insomnia, avoid taking Daclatasvir close to bedtime.
Use in Driving and Operating Machinery
Daclatasvir may cause dizziness or blurred vision in some individuals. Therefore, it is advised that you should avoid driving or operating heavy machinery until you are sure how this medication affects you.
Use in Pregnancy and Lactation
The use of Daclatasvir during pregnancy is not recommended unless the potential benefits outweigh the risks. Breastfeeding mothers should use this medicine only after consulting with their doctor.
Caution in Other Conditions
Patients with pre-existing liver disease other than hepatitis C should exercise caution while using Daclatasvir.
Also, those with kidney disease should consult their doctor before starting this medication, as dosage adjustments may be required.
Special Dietary and Lifestyle Recommendations
Refrain from sharing personal items like razors or toothbrushes to prevent spreading hepatitis C to others.
Ensure to get regular check-ups to monitor your liver function while on this medication.
Frequently asked questions
Is Daclatasvir a steroid?
No, Daclatasvir is not a steroid. It is an antiviral medicine used for managing chronic hepatitis C virus (HCV) infection in adults.
Are there any natural alternatives to Daclatasvir?
No known natural alternatives provide the same antiviral effect against HCV as Daclatasvir. Always consult your doctor before trying any alternative therapies for HCV management.
Can Daclatasvir affect mood or hormones?
Daclatasvir does not typically affect mood or hormones. However, side effects like insomnia and fatigue might indirectly affect your mood.
Can I buy Daclatasvir over the counter?
No, Daclatasvir is a prescription medication and is not available over the counter.
Does Daclatasvir have any effect on sleep?
Insomnia is one of the common side effects associated with Daclatasvir, it can affect sleep in some people. If you are experiencing sleep disturbances while on this medication, it is important to consult your doctor.
Will Daclatasvir affect fertility?
Daclatasvir is not known to affect fertility. If you are planning to conceive or have concerns about fertility while on this medication, you should discuss this with your doctor.
Is it safe to take Daclatasvir daily?
Yes, it is safe to take Daclatasvir daily as long as it is prescribed by your doctor. Always adhere to your doctor's instructions regarding the dosage and duration of this medicine.
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