Carboplatin
Uses of Carboplatin
Carboplatin is mainly used for the management of advanced ovarian carcinoma and small-cell lung cancer. It falls under the category of platinum-based antineoplastic agents.
It is also used off-label for managing other types of cancers, including breast, esophageal, stomach, bladder, cervical, endometrial, testicular cancers, brain tumors, lymphoma, leukemia, and multiple myeloma.
Side effects of Carboplatin
Nausea and vomiting
Fatigue
Decreased blood cell counts
Hair loss
Mouth sores
How Carboplatin works
Carboplatin is a platinum-based antineoplastic agent.
It works by forming bonds with the DNA inside the cancer cells, which prevents the DNA from replicating and growing. This halts the cancer cells' growth and multiplication, ultimately leading to their death.
Certified content
Written By
Doctor of Medicine
Reviewed By
BAMS, APG, PG
Expert Advice
Dosage Forms Available
Carboplatin is available as a solution for intravenous administration.
Age and Dose Restrictions
Carboplatin is typically used for the management of certain types of cancer in adults. However, it can also be used under strict medical supervision for the treatment of some specific types of cancers in children.
Contraindications
Carboplatin is contraindicated in patients with known allergies to carboplatin or other platinum-containing compounds.
It should not be given to patients with severe kidney disease or significant hearing impairment without careful consideration by a doctor.
Other Medications to Avoid
Carboplatin may interact with aminoglycoside antibiotics (e.g., gentamicin, tobramycin) and loop diuretics (e.g., furosemide).
Overdose and Missed Dose
An overdose of Carboplatin can lead to severe side effects like bone marrow suppression, kidney damage, and hearing loss. In case of suspected overdose, immediate medical attention is required.
If you miss a dose, the next dose should be administered at the scheduled time. Do not double the dose to make up for the missed one.
Management of Side Effects
Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.
Take rest to manage fatigue caused by Carboplatin.
Maintain good oral hygiene to avoid mouth sores.
Use in Driving and Operating Machinery
Carboplatin may cause fatigue and dizziness. Therefore, avoiding driving or operating heavy machinery is advised until you know how Carboplatin affects you.
Use in Pregnancy and Lactation
Carboplatin may cause harm to the unborn baby; therefore, it is not recommended during pregnancy.
As it is unknown whether Carboplatin passes into breast milk, breastfeeding should be discontinued during therapy with this medication.
Caution in Other Conditions
Carboplatin needs to be used with caution in patients with pre-existing kidney disease or hearing impairment.
This medicine can reduce blood cell counts and increase the risk of infections; therefore, caution is advised in patients with lower immunity or those prone to infections.
Special Dietary and Lifestyle Recommendations
Carboplatin can affect kidney function, so staying well-hydrated is important to help your kidneys process.
Carboplatin can lead to mouth sores and an increased risk of infections. Use a gentle, alcohol-free mouthwash or a saltwater rinse (1 tsp of salt in 1 cup of warm water) to keep your mouth clean and reduce the risk of sores.
Regular follow-ups with your doctor are essential for monitoring your response to treatment and managing side effects.
Frequently asked questions
Is Carboplatin a steroid?
No, Carboplatin is not a steroid. It is a chemotherapy medication used to manage various types of cancer.
Does Carboplatin have any effect on sleep?
Carboplatin can lead to fatigue but it does not generally affect your sleep directly. However, if you are experiencing sleep disruptions, it could be linked to other symptoms or side effects, so it is advisable to consult your doctor.
Will Carboplatin affect fertility?
Yes, Carboplatin has the potential to cause temporary or permanent infertility in both males and females. It is advisable to discuss fertility preservation options with your doctor before starting treatment.
Is it safe to take Carboplatin daily?
Carboplatin is administered intravenously as a short infusion, with the schedule determined by your doctor based on the type of cancer, overall health, and kidney function. Follow your doctor's instructions.
How much time does Carboplatin take to work?
The exact time for Carboplatin to start showing its effects can vary depending on several factors including the type of cancer and individual patient characteristics.
What is the best time to take Carboplatin?
As Carboplatin is administered intravenously in a healthcare setting, your doctor determines the timing of administration based on your treatment schedule.
What is the duration of treatment with Carboplatin?
The duration of treatment with Carboplatin depends on the type of cancer being managed, the specific treatment regimen, and the patient's response to therapy, all of which are determined by your doctor.
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