Cabozantinib
Uses of Cabozantinib
Cabozantinib is primarily used for the management of various types of cancer, including advanced renal cell carcinoma (kidney cancer), hepatocellular carcinoma (liver cancer), and differentiated thyroid cancer. It belongs to a class of medications known as kinase inhibitors.
Additionally, Cabozantinib can be used in combination with other medicines, such as nivolumab, for an effective first-line treatment in patients with advanced kidney cancer. It may also be administered in cases where other therapeutic options have been exhausted or proven ineffective.
Side effects of Cabozantinib
Diarrhoea
Fatigue
Decreased appetite
Hypertension
Nausea
How Cabozantinib works
Cabozantinib is classified as a kinase inhibitor.
It works by blocking certain proteins known as tyrosine kinases (specifically MET, VEGFR, AXL, and RET). These proteins play a critical role in the growth and spread of cancer cells. By inhibiting these kinases, Cabozantinib hinders the growth, progression, and spread of cancer cells within the body.
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Expert Advice
Dosage Forms Available
Cabozantinib is available for oral administration in the form of tablets.
Age and Dose Restrictions
Cabozantinib is suitable for adult patients and for paediatric patients 12 years and older.
Contraindications
No medical conditions have been listed as contraindications for Cabozantinib.
Other Medications to Avoid
Cabozantinib can interact with strong CYP3A4 inhibitors (such as ketoconazole, and ritonavir) and strong CYP3A4 inducers (such as rifampicin).
Overdose and Missed Dose
Overdosing on Cabozantinib may lead to severe side effects. In cases of suspected overdose, supportive care should be provided, and adverse reactions should be managed symptomatically. Dialysis may not be effective due to the high protein binding of the medicine.
If you miss a dose of Cabozantinib, take it as soon as you remember. However, if it is close to your next scheduled dose, skip the missed dose and go back to your regular dose schedule.
Management of Side Effects
Most side effects are temporary and generally harmless, and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.
Drinking plenty of water can help manage side effects such as constipation.
If you are experiencing side effects like diarrhoea, try taking Cabozantinib at least one hour before or two hours after eating.
Use in Driving and Operating Machinery
Cabozantinib may cause fatigue or dizziness which could potentially affect your ability to drive or operate machinery. It is advised to avoid doing so until you know how the medicine affects you.
Use in Pregnancy and Lactation
Cabozantinib can cause fetal harm when administered to a pregnant woman. It is also not recommended during breastfeeding. Consult with your doctor before using this medicine if you are pregnant or breastfeeding.
Caution in Other Conditions
Patients with a history of bleeding, hypertension, open wounds, and liver impairment need to exercise caution when taking Cabozantinib.
Special Dietary and Lifestyle Recommendations
Stress management techniques such as meditation, yoga, or other relaxation techniques may help manage stress associated with cancer diagnosis and treatment.
Frequently asked questions
Can Cabozantinib cause sleep disorders?
Some patients taking Cabozantinib may experience symptoms like fatigue, which might indirectly affect their sleep patterns. However, direct sleep disturbances are not commonly reported with its use. If you experience any concerning symptoms during your treatment, consult your doctor promptly.
Does Cabozantinib affect fertility?
Cabozantinib can potentially harm a developing fetus when administered to pregnant women. Therefore, females of reproductive potential are advised to use effective contraception during treatment and for four months after the final dose. However, specific effects on fertility have not been reported.
Are there specific food items to avoid while taking Cabozantinib?
Cabozantinib should be taken at least one hour before or two hours after eating. There are no specific food items that need to be avoided while taking this medicine unless otherwise advised by your doctor.
Can one take Cabozantinib indefinitely?
The duration for which Cabozantinib is taken depends upon the individual's medical condition and response to treatment. It is usually taken until disease progression or unacceptable toxicity occurs.
How long does it take for Cabozantinib to start showing effects?
The time taken for Cabozantinib to show its effects will depend on the type and stage of cancer being managed. However, as it slows down the growth and spread of cancer cells, improvements may not be immediately apparent.
Do I need a prescription to buy Cabozantinib?
Yes, Cabozantinib is a prescription medicine and it should be taken under the supervision of a doctor.
Will stopping Cabozantinib abruptly cause withdrawal symptoms?
There is no known risk of withdrawal symptoms associated with stopping Cabozantinib suddenly. However, you should always consult with your doctor before making any changes to your prescribed medication plan.
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