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Bicalutamide

Uses of Bicalutamide

  • The main use of Bicalutamide is in the management of advanced prostate cancer in men. It belongs to a group of medications known as nonsteroidal anti-androgens.

Side effects of Bicalutamide

  • Hot flashes

  • Gynaecomastia (breast enlargement and tenderness)

  • General pain (including back, pelvis, and abdominal pain)

  • Weakness and fatigue

  • Constipation or diarrhoea

How Bicalutamide works

  • Bicalutamide is a type of medicine known as a nonsteroidal anti-androgen.

  • Its main function is to block the effects of androgens, which are male hormones. It achieves this by attaching itself to androgen receptors found in the cells of the prostate. By doing this, this medicine prevents androgens from acting on the prostate cells. This action slows down or stops the growth and spread of prostate cancer cells. Thus, this medicine acts as an important part of the management strategy for advanced prostate cancer in combination with other medications, such as luteinizing hormone-releasing hormone (LHRH) agonists.

Certified content

Written By

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Dr Nikita LoboMedical Editor & Reviewer| 7 Years

BDS, MDS

Reviewed By

Dr. Divya Chauhan
Dr. Divya ChauhanMedical Writer & Reviewer| 6 Years

BAMS, APG, PG

Expert Advice

Dosage Forms Available

  • Bicalutamide is available as an oral medication in the form of tablets.

Age and Dose Restrictions

  • Bicalutamide is approved for use in adult men. It is not indicated for use in women or children.

Contraindications

  • Bicalutamide should not be taken by those who have a known allergy to it. It is also contraindicated in patients with severe liver disease due to the risk of liver injury.

Other Medications to Avoid

  • Bicalutamide can interact with other medicines such as anxiety treatment medicines (e.g., alprazolam, triazolam), anticoagulants (e.g., warfarin, jantoven) and calcium channel blockers (e.g., amlodipine, diltiazem).

Overdose and Missed Dose

  • Overdose of Bicalutamide may lead to increased severity of side effects such as bone, back, or pelvic pain. If an overdose occurs, supportive measures should be taken under medical supervision.

  • If a dose is missed, it should be taken as soon as remembered. But if it is almost time for the next dose, the missed dose should be skipped, and the regular dosing schedule should be resumed.

Management of Side Effects

Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.

  • For hot flashes, wearing light clothing and keeping comfortably cool may help.

  • Increased fluid intake may help manage constipation.

Use in Driving and Operating Machinery

  • Bicalutamide may cause dizziness and fatigue, which can impair the ability to drive or operate heavy machinery. Patients should avoid these activities if they experience these side effects.

Use in Pregnancy and Lactation

  • Bicalutamide is not indicated for use in women. Therefore, it should not be used during pregnancy or breastfeeding.

Caution in Other Conditions

  • Bicalutamide is mainly metabolised by the liver. So, caution must be exercised in patients with liver impairment.

Special Dietary and Lifestyle Recommendations

  • Avoid grapefruit products.

Frequently asked questions

No, Bicalutamide is not a steroid. It belongs to a group of medications known as nonsteroidal anti-androgens, which are used to manage prostate cancer in men.

While it is not directly linked to sleep disturbances, some side effects, such as fatigue and weakness associated with Bicalutamide, may indirectly impact sleep. Therefore, any noticeable changes in sleep patterns should be discussed with your doctor.

Yes, Bicalutamide can potentially impair male fertility. This effect may be reversible upon discontinuation of the medication, but it is a good idea to discuss any fertility concerns with your doctor before starting treatment.

The frequency and dosage of Bicalutamide should always be decided by the doctor. Ensure to follow the same.

Bicalutamide can be taken either with or without food, but it should be taken at the same time each day for maximum effectiveness.

There are no natural alternatives that have been proven to have the same effectiveness as Bicalutamide in managing advanced prostate cancer. Always consult your doctor before starting any new medication or supplement.

Bicalutamide should be taken at the same time each day, in the morning or evening, with or without food, as per your doctor's instructions.

Terms & Conditions

Available medicines for BICALUTAMIDE
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