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Bevacizumab

Uses of Bevacizumab

  • The primary use of Bevacizumab is to manage several types of cancers. It belongs to the class of monoclonal antibody medications.

  • It is useful in managing metastatic colorectal cancer, non-squamous non-small cell lung cancer, recurrent glioblastoma, metastatic renal cell carcinoma, persistent or metastatic cervical cancer, epithelial ovarian cancer, fallopian tube cancer, primary peritoneal cancer, and hepatocellular carcinoma.

Side effects of Bevacizumab

  • High blood pressure

  • Fatigue

  • Diarrhoea

  • Low white blood cell count

  • Dry, scaling skin

How Bevacizumab works

  • Bevacizumab is a monoclonal antibody.

  • It works by attaching itself to a protein called vascular endothelial growth factor or VEGF. Normally, VEGF stimulates the growth of new blood vessels, a process called angiogenesis. Tumours, which are abnormal growths of body cells, require a constant supply of nutrients and oxygen for their growth and spread. They get these from blood vessels. By binding to VEGF, Bevacizumab inhibits the formation of these new blood vessels around the tumour. Consequently, it starves the tumours of their required nutrients and oxygen, thereby slowing down their growth and spread.

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Written By

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Ashmita BorgohainMedical Content Writer & Editor|

MSc (Applied Genetics)

Reviewed By

Dr. Chhavi Rosha
Dr. Chhavi Rosha Health & Medical Content Writer| 8 Years

BMS, FMC, MD Resident

Expert Advice

Dosage Forms Available

  • Bevacizumab can be administered intravenously (solution).

Age and Dose Restrictions

  • This medication is primarily meant for adults. Use in children is strictly under a doctor's direction.

Contraindications

  • This medicine is contraindicated in patients with known hypersensitivity to Bevacizumab or any of its components.

Other Medications to Avoid

  • Bevacizumab may interact with other antineoplastic agents (like sunitinib) and immunosuppressants (such as tacrolimus or cyclosporine). Patients should inform their doctor about all the medicines they are taking, including any prescription medicines, over-the-counter medicines, vitamins, and herbal supplements while on the course of this medication.

Overdose and Missed Dose

  • Overdose of Bevacizumab may result in severe complications. In case of suspected overdose, seek immediate medical attention.

  • If you miss a dose of this medicine, administer it as soon as you remember. If it is close to your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Never double the dose to make up for the missed one.

Management of Side Effects

Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.

  • Drinking plenty of water can help manage some side effects such as dry mouth.

  • Resting and avoiding strenuous activities can help manage fatigue.

Use in Driving and Operating Machinery

  • Bevacizumab may cause fatigue or dizziness, which may impact your ability to drive or operate machinery safely. Avoid doing so if you experience these side effects after the administration of the medicine.

Use in Pregnancy and Lactation

  • Bevacizumab may cause foetal harm if used during pregnancy and impair fertility. Effective contraception should be used by women during and for at least 6 months after treatment. Breastfeeding is not recommended during treatment and for 6 months after the last dose.

Caution in Other Conditions

  • Patients with a history of bleeding problems, blood clots, stroke or mini-stroke, recent major surgery, stomach or intestinal ulcers, diabetes, or high blood pressure should exercise caution when taking Bevacizumab.

Special Dietary and Lifestyle Recommendations

  • Regular blood pressure monitoring is recommended as Bevacizumab may cause high blood pressure.

  • Regular follow-up visits are essential to track the progress of the cancer treatment.

Frequently asked questions

No, Bevacizumab is not a steroid. It is a monoclonal antibody medication which is mainly used to manage various types of cancer.

There are no direct effects of Bevacizumab on sleep. However, side effects such as fatigue may indirectly affect sleep.

Yes, there can be an impact on fertility with the use of Bevacizumab. This medicine can impair fertility and is not recommended for use during pregnancy.

The exact time for Bevacizumab to start showing its effects can vary depending on the type of cancer and the individual's response to the medicine.

Bevacizumab is administered by intravenous infusion under the supervision of a healthcare professional. The timing and frequency of the administration are determined by your doctor.

The duration of treatment with Bevacizumab varies depending upon the type of cancer and response of the patient to treatment.

No, Bevacizumab is not available over the counter. It is a prescription medication and should be used under the supervision of a doctor.

Terms & Conditions

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