Bendamustine
Uses of Bendamustine
Bendamustine is primarily used to manage certain types of blood cancers such as Chronic Lymphocytic Leukaemia (CLL), Non-Hodgkin's Lymphoma (NHL), and Multiple Myeloma. It is a part of the class of medications known as alkylating agents.
Apart from these main indications, Bendamustine is occasionally employed in an off-label capacity in combination with other medicines to manage multiple myeloma, a type of cancer that affects the plasma cells in the bone marrow.
Side effects of Bendamustine
Nausea and vomiting
Fatigue
Fever and chills
Skin reactions such as rash, itching, and skin irritation
How Bendamustine works
Bendamustine is a type of chemotherapy medication known as an alkylating agent.
It works by interacting with the DNA within cancer cells. It creates links between the DNA strands, which prevents these cells from dividing and growing. This causes damage to the cells and eventually leads to their death.
Certified content
Written By
Doctor of Medicine
Reviewed By
BMS, FMC, MD Resident
Expert Advice
Dosage Forms Available
Bendamustine is available as a powder for reconstitution and dilution, which is administered intravenously (IV).
Age and Dose Restrictions
This medicine is intended for use in adults aged 18 or over only.
Contraindications
Bendamustine is contraindicated in patients with known hypersensitivity to bendamustine or any of its components.
Other Medications to Avoid
Bendamustine can interact with antibiotics (such as ciprofloxacin), immunosuppressants (like cyclosporine), and anticoagulants (like warfarin).
Overdose and Missed Dose
Overdosing on Bendamustine can lead to serious health complications such as severe infections, tumour lysis syndrome, and infusion reactions. In case of a suspected overdose, emergency medical attention should be sought immediately.
If you miss a dose of Bendamustine, consult your doctor immediately for advice. Do not administer a double dose to compensate for the missed one.
Management of Side Effects
Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.
Resting adequately can help to manage fatigue.
Mild skin reactions can be managed by applying gentle moisturisers.
Use in Driving and Operating Machinery
As Bendamustine may cause fatigue or dizziness, caution should be exercised when driving or operating heavy machinery after administration.
Use in Pregnancy and Lactation
It is not recommended to use Bendamustine during pregnancy and lactation unless advised by the doctor due to potential risk to the foetus or infant. Consult your doctor before use.
Caution in Other Conditions
Bendamustine should be used with caution in patients with bone marrow suppression or active infections, as it may worsen these conditions.
Special Dietary and Lifestyle Recommendations
Regular hydration can help manage some side effects of chemotherapy.
Regular blood tests are recommended to monitor blood cell counts, liver function, and kidney function throughout the treatment period.
Frequently asked questions
Does Bendamustine belong to the class of steroids?
No, Bendamustine does not belong to the class of steroids. It is an alkylating agent which is a type of chemotherapy medicine.
Can administering Bendamustine affect my sleep patterns?
While sleep disturbances are not a commonly reported side effect of Bendamustine, individual reactions may vary. If you experience any changes to your sleep patterns while administering this medicine, please consult your doctor.
Is Bendamustine likely to affect fertility in men or women?
Yes, Bendamustine can potentially affect fertility in both men and women. It may cause temporary or permanent infertility by affecting sperm production in men and ovarian function in women. Patients concerned about fertility should discuss options with their doctor before starting treatment.
Is it safe for me to take Bendamustine daily?
The frequency and duration of taking Bendamustine are determined by your doctor based on your specific condition and response to treatment.
How long does it typically take for Bendamustine to start working?
The time for Bendamustine's effect to become noticeable may vary depending on the type of cancer being treated and the individual patient's response to the medication.
Is there an ideal time of day to administer Bendamustine?
The timing of administering Bendamustine is typically based on your treatment schedule decided by your doctor and is not linked to specific times of the day.
Will my condition worsen after stopping Bendamustine therapy?
Bendamustine is primarily used to manage cancer symptoms rather than cure the condition entirely. It is important to consult your doctor regarding the discontinuation of therapy to avoid any potential adverse effects or worsening conditions.
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