Bempedoic Acid
Uses of Bempedoic Acid
- Bempedoic Acid is mainly used to manage primary hypercholesterolemia (a condition where blood cholesterol levels exceed normal limits) or mixed dyslipidemia in adults when statins are intolerable for managing the condition. It belongs to the class of medicines known as ACL inhibitors.
Side effects of Bempedoic Acid
- Anaemia
- Elevated levels of uric acid levels in the blood (gout)
- Pain in arms, legs, shoulders
- Blood tests showing liver abnormalities
- Decreased GF
How Bempedoic Acid works
Bempedoic Acid is an adenosine triphosphate-citrate lyase (ACL) inhibitor.
It works by inhibiting ATP citrate lyase, an enzyme crucial for synthesizing cholesterol, particularly low-density lipoprotein (LDL or "bad" cholesterol). This inhibition promotes increased uptake and clearance of LDL in the liver, leading to reduced total blood cholesterol levels.
Certified content
Written By
Doctor of Medicine
Reviewed By
BMS, FMC, MD Resident
Expert Advice
Dosage Forms Available
- Bempedoic Acid is available in tablet form for oral administration.
Age and Dose Restrictions
- This medication is meant for adults only. It is not recommended for use in children or adolescents below 18 years of age.
Contraindications
- This medication is contraindicated in patients with a known hypersensitivity to bempedoic acid or any other constituents of this medicine.
Other Medications to Avoid
- Bempedoic Acid may interact with statins (e.g., simvastatin, pravastatin), which are used to manage high cholesterol levels. It may also interact with medicines used to manage pulmonary artery hypertension (e.g., bosentan), medicines used to manage high blood pressure and heart failure (e.g., fimasartan), and medicines used to manage hepatitis C (e.g., asunaprevir, glecaprevir, grazoprevir, voxilaprevir).
Overdose and Missed Dose
- An overdose of this medicine can lead to the risk of developing unwanted side effects. If you suspect an overdose, you should immediately consult your doctor.
- If you miss a dose of this medicine, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not take two doses at once to make up for a missed dose.
Management of Side Effects
Most side effects are temporary and generally harmless and resolve upon discontinuation of this medicine. However, if you experience any severe side effects or worsening of the symptoms, please consult your doctor.
- Drinking plenty of water can help manage some of the side effects like dry mouth and constipation.
- Taking this medicine with food may help reduce gastrointestinal side effects like stomach upset.
Use in Driving and Operating Machinery
- This medicine does not typically affect your ability to drive or operate machinery. However, if you experience side effects like dizziness after taking this medication, avoid driving or operating heavy machinery.
Use in Pregnancy and Lactation
- This medicine is not recommended during pregnancy and lactation unless necessary. If you are pregnant or breastfeeding, consult your doctor before using this medicine.
Caution in Other Conditions
- Patients with a history of gout or elevated uric acid levels should exercise caution when using Bempedoic Acid, as it may exacerbate these conditions.
- Individuals with a tendency towards tendon injuries or existing tendon disorders should also be cautious.
Special Dietary and Lifestyle Recommendations
- Maintaining a healthy diet low in saturated fats and cholesterol can aid the effectiveness of Bempedoic Acid in managing high cholesterol levels.
- Regular physical activity is important for maintaining cardiovascular health and supporting the management of high cholesterol.
Frequently asked questions
Is Bempedoic Acid related to steroids in any way?
No, it is not related to steroids. It belongs to a group of medicines known as ACL inhibitors.
Does Bempedoic Acid influence sleep patterns in any way?
There is no evidence suggesting that it directly influences sleep patterns. However, as with any medication, individual reactions may vary. If you experience any unusual sleep disturbances, consult your doctor.
Does Bempedoic Acid affects fertility?
The research does not suggest that it can affect fertility in men or women. If you have concerns about fertility, it is best to discuss this with your doctor before starting the medication.
Are there any dietary restrictions while taking Bempedoic Acid?
No specific diet restrictions are associated with the use of Bempedoic Acid. Nonetheless, a heart-healthy diet is often recommended alongside the medicine to maximise its effect in reducing LDL cholesterol levels.
Is Bempedoic Acid suitable for vegetarians and vegans?
It is typically suitable for vegetarians and vegans. However, it is always best to consult your doctor or pharmacist to confirm.
How long does it take for Bempedoic Acid to show its effect?
The time taken for this medicine to show its effect can vary based on individual factors such as age, metabolism, and severity of the condition. You should consult your doctor for specific details.
When is the best time to take Bempedoic Acid?
It can be taken at any time of the day, with or without food. However, it is usually recommended to take it at the same time each day for maximum effectiveness.
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