Aztreonam
Uses of Aztreonam
The main use of Aztreonam is for managing serious bacterial infections caused by susceptible gram-negative bacteria including complicated and uncomplicated urinary tract infections (UTIs), lower respiratory tract infections, septicemia, bacterial meningitis, skin and structure infections, intra-abdominal infections and gynecologic infections. It belongs to the group of monobactam antibiotics.
Side effects of Aztreonam
Pain or tenderness at the injection site
Rash
Diarrhoea
Nausea
Eosinophilia
How Aztreonam works
Aztreonam is a monobactam antibiotic.
It works by inhibiting the synthesis of bacterial cell walls. This happens because Aztreonam binds to penicillin-binding proteins which are essential for bacteria to build their cell walls. When Aztreonam interferes with this process, it weakens the bacterial cell wall. This leads to a rupture or burst of the bacterial cell, which ultimately kills the bacteria. Therefore, Aztreonam plays a crucial role in fighting off serious infections caused by gram-negative bacteria which are resistant to other antibiotics.
Certified content
Written By
MSc (Applied Genetics)
Reviewed By
BMS, FMC, MD Resident
Expert Advice
Dosage Forms Available
Aztreonam is available in the form of a powder for reconstitution, which is meant for use via parenteral routes intravenously (infusion) or intramuscular (injection).
Age and Dose Restrictions
Aztreonam is intended for use in adults and paediatric patients above the age of 9 months.
Contraindications
Aztreonam is contraindicated in patients who have shown hypersensitivity to aztreonam or any other ingredient present in the formulation.
Other Medications to Avoid
Aztreonam may interact with aminoglycosides (such as gentamicin and neomycin) and cephalosporins (such as cefazolin and ceftriaxone).
Overdose and Missed Dose
An overdose of Aztreonam may cause symptoms like seizures and impaired kidney function. In case of an overdose, it is important to discontinue the medicine and seek immediate medical attention.
If you miss a dose of Aztreonam, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular schedule.
Management of Side Effects
Most side effects of Aztreonam are temporary and generally harmless. They resolve once the medicine is discontinued. However, if you experience any severe side effects or worsening of symptoms, please consult your doctor.
Drinking plenty of water can help manage some gastrointestinal side effects like nausea and vomiting.
Resting or getting enough sleep can help if you experience dizziness or fatigue.
Use in Driving and Operating Machinery
Aztreonam does not usually affect the ability to drive or operate heavy machinery. However, if you feel dizzy or tired after receiving this medicine, it is advised to avoid driving or operating machinery.
Use in Pregnancy and Lactation
It is recommended to use this medicine during pregnancy only if the potential benefit justifies the potential risk to the foetus. Nursing mothers should consult their doctor before taking this medicine.
Caution in Other Conditions
Patients with kidney problems should exercise caution when taking Aztreonam, as dosage adjustment may be needed based on renal function.
This medicine should also be used cautiously in patients with a history of allergies or hypersensitivity reactions to antibiotics.
Special Dietary and Lifestyle Recommendations
Regular handwashing and good personal hygiene practices can prevent the spread of infections.
Keeping all your vaccinations up-to-date can also help prevent certain bacterial infections.
Frequently asked questions
Is Aztreonam a type of steroid?
No, Aztreonam is not a steroid. It is a monobactam antibiotic used for managing serious bacterial infections.
Does taking Aztreonam have any effect on my sleep patterns?
Aztreonam is not known to affect sleep patterns. However, if you experience any such issues, do consult your doctor.
Could the use of Aztreonam potentially affect my fertility?
There is no known impact of Aztreonam on fertility. If you have concerns about this, please consult your doctor.
Is it safe to administer Aztreonam daily?
Aztreonam should be administered as per the recommended dosage by your doctor. Prolonged or excessive use without medical supervision may lead to antibiotic resistance.
How long does it take for the effect of Aztreonam to kick in?
The onset of action of Aztreonam can vary depending on the severity of the infection and individual patient factors. Always follow your doctor's guidance regarding dose and duration.
What is the best time to administer Aztreonam?
The timing for administering Aztreonam will depend upon your doctor's instructions, considering factors such as the type and severity of your infection.
Is the Aztreonam available over the counter, or do I need a prescription?
Aztreonam usually requires a prescription from a registered medical practitioner and is not usually available over the counter.
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