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Axitinib

Uses of Axitinib

  • The primary use of Axitinib is for managing advanced renal cell carcinoma (kidney cancer) in adults who have had inadequate response to one prior systemic therapy. It belongs to the group of medicines known as tyrosine kinase inhibitors.

Side effects of Axitinib

  • Diarrhoea

  • High blood pressure

  • Fatigue

  • Decreased appetite

  • Nausea and vomiting

How Axitinib works

  • Axitinib is a type of medicine known as a tyrosine kinase inhibitor.

  • It acts by selectively blocking the receptors for vascular endothelial growth factor (VEGF), a protein that plays a significant role in tumour angiogenesis, the process by which new blood vessels form to supply nutrients to cancer cells. By inhibiting VEGF receptors, Axitinib reduces the blood supply to the tumour, thereby slowing down its growth and spread.

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Written By

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Dr Nikita LoboMedical Editor & Reviewer| 7 Years

BDS, MDS

Reviewed By

Dr. Chhavi Rosha
Dr. Chhavi Rosha Health & Medical Content Writer| 8 Years

BMS, FMC, MD Resident

Expert Advice

Dosage Forms Available

  • Axitinib is available in the form of oral tablets.

  • This medicine is taken by mouth.

Age and Dose Restrictions

  • Axitinib is intended for adult use only.

Contraindications

  • Axitinib should not be used in patients with known hypersensitivity to the active ingredient or any of the components of the formulation.

Other Medications to Avoid

  • Axitinib can interact with blood pressure lowering medicines (such as amlodipine, lisinopril), anticoagulants (such as warfarin, dabigatran), and medications affecting liver enzymes (such as ketoconazole, rifampin). It may also interact with other anti-cancer drugs (such as sunitinib, sorafenib) and medications affecting gastrointestinal pH (such as omeprazole, ranitidine).

Overdose and Missed Dose

  • In case of an overdose, immediate medical attention is required as it may lead to severe adverse effects.

  • If you miss a dose of Axitinib, take the next dose at your regular scheduled time. Do not double the dose to catch up.

Management of Side Effects

Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.

  • For the management of diarrhoea, consider adjusting the timing of medication intake.

  • Stay well hydrated to help manage symptoms like dry mouth or mild dehydration from diarrhoea.

Use in Driving and Operating Machinery

  • Axitinib may impair your ability to drive or operate heavy machinery. Be cautious if you feel dizzy or fatigued during treatment.

Use in Pregnancy and Lactation

  • Axitinib is not recommended during pregnancy or while breastfeeding due to the potential risk to the foetus and breastfed infant.

  • Consult your doctor for advice on taking Axitinib during pregnancy or lactation.

Caution in Other Conditions

  • Caution is advised for patients with liver impairment when taking Axitinib. Regular liver function tests are recommended.

  • Patients with a history of bleeding or thrombosis should use Axitinib with caution due to an increased risk of these events.

Special Dietary and Lifestyle Recommendations

  • Maintain a balanced diet rich in fruits, vegetables, and lean proteins to support overall health.

  • Monitor blood pressure regularly; consider dietary adjustments such as reducing sodium intake to manage hypertension.

  • Avoid consumption of grapefruit or grapefruit juice as it can interact with Axitinib and affect its efficacy.

  • Engage in light to moderate physical activities, such as walking or yoga, which can help manage fatigue and improve overall well-being.

  • Manage stress through relaxation techniques like meditation or deep-breathing exercises.

Frequently asked questions

No, Axitinib does not belong to the class of steroids. It is a medicine that belongs to a group known as tyrosine kinase inhibitors.

There are no known side effects of Axitinib directly impacting sleep. However, if you experience unusual sleep patterns after starting this medicine, it is advisable to consult your doctor.

The impact of Axitinib on fertility is not explicitly reported. However, always consult your doctor if you plan to conceive while you are on Axitinib or have concerns about your fertility.

Yes, when taking Axitinib, it is advisable to avoid grapefruit and grapefruit juice as they can increase the levels of this medicine in your blood.

Axitinib is generally taken every day, as long as it is prescribed by your doctor. Do not stop or start taking this medicine without consulting your doctor.

The time it takes for Axitinib to start showing effects can vary from patient to patient. In some people, a reduction in tumour size was noticed within the first 8 weeks of treatment.

Axitinib is not an over-the-counter medicine. It requires a prescription from a doctor.

Terms & Conditions

Available medicines for AXITINIB
Axpero 5 MG Tablet 14
Axpero 5 MG Tablet 14
Intas Pharmaceuticals Ltd
Pack of 14 Units
₹1635.90
MRP ₹1995.00
18.00% OFF
Inlyta 5 MG Tablet 14
Inlyta 5 MG Tablet 14
Pfizer Ltd
Pack of 14 Units
₹34224.34
MRP ₹41737.00
18.00% OFF
Axinib 1 MG Tablet 14
Axinib 1 MG Tablet 14
Amps Biotech Pvt Ltd
Pack of 14 Units
₹1025.00
MRP ₹1250.00
18.00% OFF
Axzyb 5mg Tablet 30
Axzyb 5mg Tablet 30
Glenmark Pharmaceuticals Ltd.
Pack of 30 Units
₹3444.00
MRP ₹4200.00
18.00% OFF
Bdaxit 5 MG Tablet 14
Bdaxit 5 MG Tablet 14
Bdr Pharmaceuticals Internationals Pvt. Ltd
Pack of 14 Units
₹1697.40
MRP ₹2070.00
18.00% OFF
Axishil 1 MG Tablet 14
Axishil 1 MG Tablet 14
Shilpa Medicare Ltd
Pack of 14 Units
₹615.00
MRP ₹750.00
18.00% OFF
Inlyta 1 MG Tablet 14
Inlyta 1 MG Tablet 14
Pfizer Ltd
Pack of 14 Units
₹6844.54
MRP ₹8347.00
18.00% OFF
Axishil 5 MG Tablet 14
Axishil 5 MG Tablet 14
Shilpa Medicare Ltd
Pack of 14 Units
₹3062.70
MRP ₹3735.00
18.00% OFF

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